~ What Is the Proper Dose of Melatonin? - References

1. de Lourdes M, et al. Randomized, double-blind clinical trial, controlled with placebo, of the toxicology of chronic melatonin treatment. Pineal Res 2000 Nov;29(4):193-200.

2. Harrison's Online http://www.medscape.com/HOL/public/HOL-journal.html. Effects of Melatonin on Sleep. Richard J. Wurtman, Cecil H. Green Distinguished Professor and Director, Clinical Research Center, MIT, Cambridge, MA [Copyright © 1998, 1999, 2000 by The McGraw-Hill Companies, Inc. Reproduced with permission of The McGraw-Hill Companies.]

3. Dawson D, et al. Effect of sustained nocturnal transbuccal melatonin administration on sleep and temperature in elderly insomniacs. J Biol Rhythms 1998 Dec;13(6):532-8.

4. Suhner A, et al. Comparative study to determine the optimal melatonin dosage form for the alleviation of jet lag. Chronobiol Int 1998 Nov;15(6):655-66.

5. Sack RL, et al. Entrainment of free-running circadian rhythms by melatonin in blind people. N Engl J Med 2000 Oct 12;343(15):1070-7.

6. Dalton EJ, et al. Use of slow-release melatonin in treatment-resistant depression. J Psychiatry Neurosci 2000 Jan;25(1):48-52.

7. Matsumoto M. The hypnotic effects of melatonin treatment on diurnal sleep in humans. Psychiatry Clin Neurosci 1999 Apr;53(2):243-5.

8. Zhdanova IV, et al. Effects of a low dose of melatonin on sleep in children with Angelman syndrome. J Pediatr Endocrinol Metab 1999 Jan-Feb;12(1):57-67.

9. Jan JE, et al. Melatonin treatment of non-epileptic myoclonus in children. Dev Med Child Neurol 1999 Apr;41(4):255-9.

10. Miyamoto A, et al. Serum melatonin kinetics and long-term melatonin treatment for sleep disorders in Rett syndrome. Brain Dev 1999 Jan;21(1):59-62.

11. Domzal TM, et al. [Melatonin in sleep rhythm disorders after cerebral stroke]. Pol Merkuriusz Lek 2000 Jun;8(48):411-2.

12. Garfinkel D, et al. Facilitation of benzodiazepine discontinuation by melatonin: a new clinical approach. Arch Intern Med 1999 Nov 8;159(20):2456-60.

13. Brusco LI, et al. Effect of melatonin in selected populations of sleep-disturbed patients. Biol Signals Recept 1999 Jan-Apr;8(1-2):126-31.

14. Fauteck J, et al. Melatonin in epilepsy: first results of replacement therapy and first clinical results. Biol Signals Recept 1999 Jan-Apr;8(1-2):105-10.

15. Dagan Y, et al. Rapid reversal of tolerance to benzodiazepine hypnotics by treatment with oral melatonin: a case report. Eur Neuropsychopharmacol 1997 May;7(2):157-60.

16. Pillar G, et al. Melatonin treatment in an institutionalised child with psychomotor retardation and an irregular sleep-wake pattern. Arch Dis Child 1998 Jul;79(1):63-4.

17. Gordon N. The therapeutics of melatonin: a paediatric perspective. Brain Dev 2000 Jun;22(4):213-7.

18. Kunz D, et al. Melatonin as a therapy in REM sleep behavior disorder patients: an open-labeled pilot study on the possible influence of melatonin on REM-sleep regulation. Mov Disord 1999 May;14(3):507-11.

19. Jean-Louis G, et al. Melatonin effects on sleep, mood, and cognition in elderly with mild cognitive impairment. J Pineal Res 1998 Oct;25(3):177-83.

20. Kato M, et al. Melatonin treatment for rhythm disorder. Psychiatry Clin Neurosci 1998 Apr;52(2):262-3.

21. Okawa M, et al. Melatonin treatment for circadian rhythm sleep disorders. Psychiatry Clin Neurosci 1998 Apr;52(2):259-60.

22. Melatonin treatment for circadian rhythm sleep disorders. Does exogenous melatonin improve day sleep or night alertness in emergency physicians working night shifts? Ann Emerg Med 1998 Jun;31(6):699-704.

23. Avery D, et al. Guidelines for prescribing melatonin. Ann Med 1998 Feb;30(1):122-30.

24. Shochat T, et al. Melatonin—the key to the gate of sleep. Ann Med 1998 Feb;30(1):109-14.

25. Rosenberg SI, et al. Effect of melatonin on tinnitus. Laryngoscope 1998 Mar;108(3):305-10.

26. Hughes RJ, et al. Sleep-promoting and hypothermic effects of daytime melatonin administration in humans. Sleep 1997 Feb;20(2):124-31.

27. Lushington K, et al. Daytime melatonin administration in elderly good and poor sleepers: effects on core body temperature and sleep latency. Sleep 1997 Dec;20(12):1135-44.

28. Kunz D, et al. Melatonin effects in a patient with severe REM sleep behavior disorder: case report and theoretical considerations. Neuropsychobiology 1997;36(4):211-4.

29. Jan JE, et al. Use of melatonin in the treatment of paediatric sleep disorders. J Pineal Res 1996 Nov;21(4):193-9.

30. Middleton B, et al. Complex effects of melatonin on human circadian rhythms in constant dim light. J Biol Rhythms 1997 Oct;12(5):467-77.

31. Nakamura K, et al. Daily melatonin intake resets circadian rhythms of a sighted man with non-24-hour sleep-wake syndrome who lacks the nocturnal melatonin rise. Psychiatry Clin Neurosci 1997 Jun;51(3):121-7.

32. Yin D. Is carbonyl detoxification an important anti-aging process during sleep? Med Hypotheses 2000 Apr;54(4):519-22.

33. Yu Q, et al. Melatonin inhibits apoptosis during early B-cell development in mouse bone marrow. J Pineal Res 2000 Sep;29(2):86-93.

34. Anisimov VN, et al. Melatonin and colon carcinogenesis. III. Effect of melatonin on proliferative activity and apoptosis in colon mucosa and colon tumors induced by 1,2-dimethylhydrazine in rats. Exp Toxicol Pathol 2000 52(1):71-6.

35. Lissoni P, et al. Immunoendocrine therapy with low-dose subcutaneous interleukin-2 plus melatonin of locally advanced or metastatic endocrine tumors. Oncology 1995 52(2):163-6.

36. Aldeghi R, et al. Low-dose interleukin-2 subcutaneous immunotherapy in association with the pineal hormone melatonin as a first-line therapy in locally advanced or metastatic hepatocellular carcinoma. Eur J Cancer 1994 30A(2):167-70.

37. Neri B, et al. Melatonin as biological response modifier in cancer patients. Anticancer Res 1998 Mar-Apr;18(2B):1329-32.

38. Lissoni P, et al. A randomized study of chemotherapy with cisplatin plus etoposide versus chemoendocrine therapy with cisplatin, etoposide and the pineal hormone melatonin as a first-line treatment of advanced non-small cell lung cancer patients in a poor clinical state. J Pineal Res 1997 Aug;23(1):15-9.

39. Kanishi Y, et al. Differential growth inhibitory effect of melatonin on two endometrial cancer cell lines. J Pineal Res 2000 28(4):227-33.

40. El-Missiry MA, et al. Influence of melatonin on proliferation and antioxidant system in Ehrlich ascites carcinoma cells. Cancer Lett 2000 151(2):119-25.

41. Reiter RJ, et al. Pharmacology and physiology of melatonin in the reduction of oxidative stress in vivo. Biol Signals Recept 2000 May-Aug;9(3-4):160-71.

42. Scalbert E, et al. [Melatonin and regulation of the cardiovascular system]. Therapie 1998 Sep-Oct;53(5):459-65.

43. Fontenot J.M., et al. Melatonin deficiency: Its role in oncogenesis and age-related pathology. Journal of Orthomolecular Medicine (Canada) 1990, 5/1 (22-24).

44. Li ZR, et al. Cataractogenesis and lipid peroxidation in newborn rats treated with buthionine sulfoximine: preventive actions of melatonin. J Pineal Res 1997 Apr;22(3):117-23Erratum in: J Pineal Res 1997 Nov;23(4):230.

45. Srinivasan V. Melatonin, biological rhythm disorders and phototherapy. Indian J Physiol Pharmacol 1997 Oct;41(4):309-28.

46. McArthur AJ, et al. Sleep dysfunction in Rett syndrome: a trial of exogenous melatonin treatment. Dev Med Child Neurol 1998 Mar;40(3):186-92.

47. Dagan Y, et al. Evaluating the role of melatonin in the long-term treatment of delayed sleep phase syndrome (DSPS). Chronobiol Int 1998 Mar;15(2):181-90.

48. Nagtegaal JE, et al. Traumatic brain injury-associated delayed sleep phase syndrome. Funct Neurol 1997 Nov-Dec;12(6):345-8.

49. Nagtegaal JE, et al. Effects of melatonin on the quality of life in patients with delayed sleep phase syndrome. J Psychosom Res 2000 Jan;48(1):45-50.

50. Shilo L, et al. Effect of melatonin on sleep quality of COPD intensive care patients: a pilot study. Chronobiol Int 2000 Jan;17(1):71-6.

51. Shamir E, et al. Melatonin improves sleep quality of patients with chronic schizophrenia. J Clin Psychiatry 2000 May;61(5):373-7.

52. Grin W, et al. A significant correlation between melatonin deficiency and endometrial cancer. Gynecol Obstet Invest 1998;45(1):62-5.

53. Hoyos M, et al. Serum cholesterol and lipid peroxidation are decreased by melatonin in diet-induced hypercholesterolemic rats. J Pineal Res 2000 Apr;28(3):150-5.

54. Vollrath L., et al. Day/night serotonin levels in the pineal gland of male BALB/c mice with melatonin deficiency. Acta Endocrinologica (Denmark) 1988, 117/1 (93- 98).

55. O'Hare J.P., et al. Does melatonin deficiency cause the enlarged genitalia of the fragile-X syndrome? Clinical Endocrinology (United Kingdom) 1986, 24/3 (327-333).

56. Scalbert E, et al. [Melatonin and regulation of the cardiovascular system]. Therapie 1998 Sep-Oct;53(5):459-65.

57. Garcia-Maurino S, et al. Melatonin activates Th1 lymphocytes by increasing IL-12 production. Life Sci 1999;65(20):2143-50.

58. Waldhauser F, et al. Alterations in nocturnal serum melatonin levels in humans with growth and aging. J Clin Endocrinol Metab 1988 Mar;66(3):648-52.

59. Brzezinski A. Melatonin in humans. N Engl J Med 1997 Jan 16;336(3):186-95.

60. Zeitzer JM, et al. Do plasma melatonin concentrations decline with age? Am J Med 1999 Nov;107(5):432-6 61.

61. Garfinkel D, et al. Improvement of sleep quality in elderly people by controlled-release melatonin. Lancet 1995 Aug 26;346(8974):541-4.

62. Saletu B. [Melatonin—a natural hypnotic]? Wien Klin Wochenschr 1997 Oct 3;109(18):714-21.

63. Zisapel N. The use of melatonin for the treatment of insomnia. Biol Signals Recept 1999 Jan-Apr;8(1-2):84-9.

64. Blaicher W, et al. Melatonin in postmenopausal females. Arch Gynecol Obstet 2000 Feb;263(3):116-8.



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