~ The Vitamin E Controversy - Special Issue - December 2004
Contents . . .
- The Vitamin E Controversy - You may have heard that vitamin E supplements can be valuable for heart health. However, a recent study has cast a shadow of doubt on vitamin E's benefit. Let's take a closer look at this study.
Read the full article . . .
- Overreaction to Vitamin E Study Could Cause Increased Health Risk - WASHINGTON, Dec 2, 2004 -- A new national poll demonstrates that 18 percent of Americans are less likely to take vitamin E based on the news suggesting high doses "may increase risk of dying" among older, high-risk patients. Many experts are concerned that a meta-analysis, released last month, may lead to an increased risk of cardiovascular disease as consumers become less likely to take the beneficial supplement -- vitamin E.
"Vitamin E is such an important antioxidant," said Barbara Levine, PhD, director of the Nutrition Information Center and associate professor of nutrition in medicine, Weill Medical College of Cornell University. "If consumers base their lifestyles on this inconclusive meta-analysis, we could see an increased risk of cardiovascular disease, cancers and age-related macular degeneration in an otherwise healthy population."
Read the full article . . .
- Understanding Vitamin E - Vitamin E is an oil soluble vitamin that is found in oils, nuts, and seeds. It is considered to be an antioxidant vitamin. Large doses will act as an anti-coagulant or blood thinner.
Vitamin E was discovered in 1922. It is only in the last decade, however, that the public began to be educated about the critical fact that "vitamin E" is not a single compound. Instead, it is a general name for a whole family of compounds. Eight forms of vitamin E have been identified as existing in nature. These belong either to the tocopherol sub-family, consisting of alpha tocopherol, beta tocopherol, gamma tocopherol and delta tocopherol, or to the tocotrienol sub-family, consisting of alpha tocotrienol, beta tocotrienol, gamma tocotrienol and delta tocotrienol. The scientific focus is slowly shifting away from "vitamin E" to specific tocopherols and tocotrienols.
It turns out that the heretofore neglected beta, gamma and delta tocopherols and tocotrienols seem to have important health benefits, including anti-inflammatory, cardioprotective and anticancer activity. Gamma tocopherol in particular also has the ability to protect against nitrogen-based free radicals, which alpha tocopherol cannot do. Nitrogen free radicals play an important role in diseases associated with chronic inflammation, including cancer, heart disease and degenerative brain disorders such as Alzheimer's disease.
Gamma tocopherol, once the neglected "poor relative" of alpha tocopherol, is now beginning to get the attention it deserves. Its anti-inflammatory, cardioprotective, anticancer and overall antiaging properties make it an important part of the life extension nutritional arsenal.
Gamma E Tocopherol - The primary purpose of supplementing with vitamin E is to suppress damaging free radicals. Scientific studies have identified the gamma-tocopherol form of vitamin E as being critical to human health. Gamma E Tocopherol offers mixed tocopherols: Gamma-tocopherol, Delta-tocopherol, Alpha-tocopherol, and Beta-tocopherol and Tocomin® Full-Spectrum Natural Tocotrienol Complex.
Gamma E Tocopherol with Sesame Lignans - New research shows that sesame lignans increase gamma-tocopherol levels in the body while reducing free radical damage. In response to these findings, Life Extension has reformulated the popular Gamma E Tocopherol supplement to replace tocotrienols with sesame lignans. This new formula provides more gamma-tocopherol than the previous version, and is fortified with standardized sesame lignans to augment the antioxidant effects of gamma-tocopherol.
Life Extension Booster Softgels - Antioxidants are critical to staving off age-related disease. This formula contains the best profile of active ingredient compounds. Other manufacturers offer polyphenols, but they do not contain the specific gallates, ellagic acids, opc's and specific anthocyanins that support the best research. LIFE EXTENSION BOOSTER Softgels do. Even the vitamin E contains more Gamma E with the other tocopherols, guaranteeing the best protection.
Vitamin E-400 IU Mixed Tocopherols - Our most comprehensive blend of tocopherols, NOW Vitamin E 400 IU Mixed is a remarkable formula that works synergistically with other antioxidants to protect the body from cellular damage caused by harmful free radicals. By combining alpha-, beta-, delta-, and gamma- tocopherols, NOW’s unique blend of these oxidation quenching nutrients is easily digested and critical to good overall health.
- Featured Product - Gamma E Tocopherol with Sesame Lignans - The primary purpose of supplementing with vitamin E is to suppress damaging free radicals. Scientific studies have identified the gamma-tocopherol form of vitamin E as being critical to human health.
New research shows that sesame lignans increase gamma-tocopherol levels in the body while reducing free radical damage. In response to these findings, Life Extension has reformulated the popular Gamma E Tocopherol supplement to replace tocotrienols with sesame lignans. This new formula provides more gamma-tocopherol than the previous version, and is fortified with standardized sesame lignans to augment the antioxidant effects of gamma-tocopherol.
- Don't Toss Your Vitamin E Yet - There's Good News - Vitamin E may help some diabetics
by Kevin Hattori, American Society for Technion - Israel Institute of Technology
NEW YORK, N.Y. and HAIFA, Israel, November 18, 2004 – Despite recent reports that show use of high-dose vitamin E supplements is associated with a higher overall risk of dying, at least one group stands to benefit greatly from the same vitamin.
About 40 percent of diabetic patients can reduce their risk of heart attacks and of dying from heart disease by taking vitamin E supplements, according to a Technion-Israel Institute of Technology study published in the November 2004 Diabetes Care.
Read more about why you should not toss your Vitamin E yet . . .
- Safe, Therapeutic Use of Vitamin E - "In the entire literature there are no reports of overdosage with vitamin E in any form." - Physicians Desk Reference for Nutritional Supplements, p. 519.
Benefits of Vitamin E
Vitamin E is found in every cell of the body. It prevents free radicals from damaging the cell walls. It protects the structure and function of muscle tissues, the pituitary and adrenal glands, the capillaries, red blood cells and sex hormones.
It can prevent sterility in males, and protects the lungs and blood cells from ozone damage. It is useful as an aid in treating fibrocystic breasts and premenstrual syndrome. It has been shown to improve circulation, heal wounds and repair tissue. It has been used as an aid in preventing cancer, cataracts, Alzheimer's, and cardiovascular disease.
"In the entire literature there are no reports of overdosage with vitamin E in any form."
- Physicians Desk Reference for Nutritional Supplements, p. 519.
Read why Vitamin E is safe . . .
- Council for Responsible Nutrition: Vitamin E Is Safe - Get the Facts - Council for Responsible Nutrition - November 2004
Like many people, you may have questions about some of the recent stories that have been in the news about vitamin E. Here is some useful advice to help you better understand the safety and benefits of vitamin E.
"I recommend vitamin E to my patients, and I will continue to do so."
Mary Hardy, MD, Associate Director, Botanical Research Center, Center for Human Nutrition, UCLA
Vitamin E meta-analysis in Annals of Internal Medicine: What's wrong with this picture?
What is a meta-analysis?
A meta-analysis is not a clinical trial. It is a statistical technique for combining the results of many existing studies in order to clarify possible effects. When studies are done with a few hundred or even a few thousand people, it is often difficult to determine whether differences between the treatment group and the placebo group are "real" or just accidents due to chance. Combining studies provides more people for analysis and thus increases statistical power. While a meta-analysis is an important scientific tool, it also has limitations.
Learn more about Vitamin E and how to understand the findings from this recent study . . .
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