~ Vitamin E Analyzed, Effects On Cell Antioxidant Defense Systems Clarified

NewsRx.com, 10-20-05

According to recent research from the United States published in the journal Brain Research, mitochondrially targeted vitamin E (MitoVit E), and vitamin E (VE) mitigate ethanol (EtOH)-mediated effects on cerebellar granule cell (CGC) antioxidant defense systems.

"EtOH disrupts the structure and function of the developing nervous system, sometimes leading to birth defects associated with fetal alcohol syndrome (FAS). Animal FAS models indicate that cellular membrane peroxidation, intracellular oxidant accumulation, and suppression of endogenous:antioxidant enzymes contribute to the toxic effects of EtOH," wrote K.I. Siler-Marsiglio and colleagues, University of Florida.

"MitoVit E, a chemically engineered form of VE designed to accumulate in the mitochondria, has been shown to inhibit intracellular oxidant accumulation and cell death more effectively than VE. In previous investigations, we have shown that, in vivo, VU reduces neuronal death in the developing cerebellum of EtOH-exposed animals, and, in vitro, VE prevents apoptotic and necrotic death of EtOH-exposed CGCs.

"The present investigation shows that, in a FAS CGC model, 1 nM MitoVit E renders significant neuroprotection against EtOH concentrations as high as 1600 mg/dL. The present study also demonstrates that, in this same model," the authors reported.

"MitoVit E mitigates EtOH-induced accumulation of intracellular oxidants and counteracts suppression of glutathione peroxidase/glutathione reductase (GSH-Px/GSSGR) functions, protein expression of gamma-glutamylcysteine synthetase (gamma-GCS), and total cellular glutathione (GSH) levels.

"In the presence and absence of EtOH, VE amplifies the protein expression levels of gamma-GCS, an enzyme that performs the rate-limiting step for GSH synthesis, and total GSH levels," continued the researchers.

"These results suggest that MitoVit E and VE ameliorate EtOH toxicity through non-oxidant mechanisms modulations of endogenous cellular proteins and antioxidant means," concluded the investigators.

Siler-Marsiglio and colleagues published their study in Brain Research (Mitochondrially targeted vitamin E and vitamin E mitigate ethanol-mediated effects on cerebellar granule cell antioxidant defense systems. Brain Res, 2005;1052(2):202-211).

For additional information, contact K.I. Silermarsiglio, University of Florida, McKnight Brain Institute, Department of Neuroscience, 100 S Newell Dr., Room L3-151, Gainesville, FL 32611, USA.

The publisher's contact information for the journal Brain Research is: Elsevier Science BV, PO Box 211, 1000 AE Amsterdam, Netherlands.

To see more of the NewsRx.com, or to subscribe, go to http://www.newsrx.com.

Free Shipping in the Continental U.S. on Orders over $50
The statements made here have not been evaluated by the FDA. The foregoing statements are based upon sound and reliable studies, and are meant for informational purposes. Consult with your medical practitioner to determine the underlying cause of your symptoms. Please always check your purchase for possible allergins and correct dosage on the bottle before use.

While we work to ensure that product information is correct, on occasion manufacturers may alter their ingredient lists. Actual product packaging and materials may contain more and/or different information than that shown on our Web site. We recommend that you do not solely rely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. For additional information about a product, please contact the manufacturer. Content on this site is for reference purposes and is not intended to substitute for advice given by a physician, pharmacist, or other licensed health-care professional. You should not use this information as self-diagnosis or for treating a health problem or disease. Contact your health-care provider immediately if you suspect that you have a medical problem. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease or health condition. Life Ex Online assumes no liability for inaccuracies or misstatements about products.