~ Taurine Supplementation Shows Potential in Diabetes Mellitus Treatment
Taurine could prevent the onset of diabetes mellitus.
According to a recent review from Italy, "Taurine is a semi-essential sulphur amino acid derived from methionine and cysteine metabolism. It has been evaluated either in experimental or clinical type 1 and 2 diabetes mellitus and insulin resistance. One form of experiment has included the possibility that perinatal taurine administration could prevent diabetes mellitus and/or insulin resistance."
F. Franconi and colleagues of the University of Sassari wrote, "Experimental data suggest strongly that taurine could have beneficial effects in type 1 diabetes mellitus, and could generally reduce organ lipid peroxidation and plasma lipids. Interestingly, retina, lens and nerves seem to respond better to taurine than other organs such as kidneys.
"It has been shown in some experimental models that in type 2 diabetes mellitus and insulin resistance there is alteration in taurine homeostasis. Taurine could prevent the onset of diabetes mellitus in NOD mice and postnatal taurine modifies the glucose-loading curves in adults. However, the clinical studies are too small and too short to have any real significance."
"Further experimental and clinical studies are required to evaluate taurine's possible therapeutic potential. Careful attention has to be paid in the selection of animal species, in standardization of taurine concentrations and patient selection. Moreover, care must also be given to the metabolic state, presence of complications, duration of supplementations and selection of the right end-points," the authors advised.
Franconi and colleagues published their review in Current Opinion in Clinical Nutrition and Metabolic Care (Taurine supplementation and diabetes mellitus. Curr Opin Clin Nutr Metab Care, 2006;9(1):32-36).
For additional information, contact F. Franconi, University of Sassari, Dept. Pharmacology, Via Muroni 23A, I-07100 Sassari, Italy.
Publisher contact information for the journal Current Opinion in Clinical Nutrition and Metabolic Care is: Lippincott, Williams, & Wilkins, 530 Walnut St., Philadelphia, PA 19106-3621, USA.
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