~ Sulforaphane Helps Block Metastasis
A report published in the May 22, 2006 issue of the journal Life Sciences revealed the findings of P. Thejass and Girija Kuttan at the Amala Cancer Research Center in Kerala, India that sulforaphane significantly prevented the metastasis of melanoma cells in mice. Sulforaphane is an isothiocyanate found in broccoli and other cruciferous vegetables that has been shown to help protect against chemically-induced tumors.
The current study utilized mice in whom melanoma tumor cells were injected. Five hundred micrograms per kilogram body weight sulforaphane was administered to one group of mice at the same time as the tumor cells were injected, while two other groups received the compound 10 days prior to and 10 days after the cells were injected. A control group of animals injected with tumor cells received no sulforaphane.
The control mice were found to have a significant amount of lung tumors compared to animals who received sulforaphane. Sulforaphane given simultaneously with the tumor cells was the most effective mode of administration, being associated with an inhibition of 95.5 percent of metastases, and an increase in lifespan of 94 percent compared to the control group. Preventive administration was the second most effective mode, which inhibited metastases by 90.51 percent and increased the lifespan of this group by 62.17. Giving sulforaphane after the tumors had developed increased lifespan by 37.85 compared to animals who did not receive the compound. In addition, sulforaphane was associated with a reduction in levels of lung tumor-associated compounds, such as lung hydroxyproline.
In-vitro research showed that sulforaphane inhibited the activation of matrix metalloproteinases, which are enzymes that degrade the cell membrane and facilitate the metastasis of tumors. The authors suggest that sulforaphane's antimetastatic activity may be mainly due to this action.
Free Shipping in the Continental U.S. on Orders over $50
The statements made here have not been evaluated by the FDA. The foregoing statements are based upon sound and reliable studies, and are meant for informational purposes. Consult with your medical practitioner to determine the underlying cause of your symptoms. Please always check your purchase for possible allergins and correct dosage on the bottle before use.
While we work to ensure that product information is correct, on occasion manufacturers may alter their ingredient lists. Actual product packaging and materials may contain more and/or different information than that shown on our Web site. We recommend that you do not solely rely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. For additional information about a product, please contact the manufacturer. Content on this site is for reference purposes and is not intended to substitute for advice given by a physician, pharmacist, or other licensed health-care professional. You should not use this information as self-diagnosis or for treating a health problem or disease. Contact your health-care provider immediately if you suspect that you have a medical problem. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease or health condition. Life Ex Online assumes no liability for inaccuracies or misstatements about products.