By a News Reporter-Staff News Editor at Blood Weekly
Investigators publish new report on Diet and Nutrition. According to news originating from New Delhi, India, by NewsRx correspondents, research stated, "Traditional medicine has been appropriately identified as the most productive soil for the cultivation and harvesting of modern medicines. Herein, we postulate that safranal, an active constituent of Crocus sativus, owing to its strong antioxidant and anti-apoptotic potential, could be a valuable molecule in alleviating myocardial ischemia-reperfusion (IR) injury."
Our news journalists obtained a quote from the research from the Government of India, "To evaluate this hypothesis, safranal (0.1-0.5 mL/kg/day, i.p.) or saline were administered to rats for 14 days, and on 15th day, one-stage ligation of left anterior descending coronary artery for 45 min was performed, followed by 60 min reperfusion. We concluded that safranal not only significantly decreased infarct size, but also improved left ventricular functions and the overall hemodynamic status of the myocardium. Interestingly, safranal enhanced phosphorylation of Akt/GSK-3 beta/eNOS and suppressed IKK-beta/NF-kappa B protein expressions in IR-challenged myocardium. Our findings also imply that safranal exhibits strong anti-apoptotic potential, as evidenced by upregulated Bcl-2 expression and downregulated Bax and caspase3 expression with decreased TUNEL positivity. Moreover, safranal dose-dependently normalized myocardial antioxidant and nitrotyrosine levels, cardiac injury markers (LDH and CK-MB), and decreased TNF-alpha level in IR-insulted myocardium. Histopathological and ultrastructural findings correlated with the functional and biochemical outcomes showing preserved myocardial architecture and decreased inflammatory cells and edema."
According to the news editors, the researchers concluded: "Taken together, these results provide convincing evidence of safranal as an invaluable molecule in myocardial IR setting probably due to its fortified antioxidant and anti-apoptotic potential."
For more information on this research see: Akt/GSK-3 beta/eNOS phosphorylation arbitrates safranal-induced myocardial protection against ischemia-reperfusion injury in rats. European Journal of Nutrition, 2012;51(6):719-727. European Journal of Nutrition can be contacted at: Springer Heidelberg, Tiergartenstrasse 17, D-69121 Heidelberg, Germany. (Springer - www.springer.com; European Journal of Nutrition - www.springerlink.com/content/1436-6207/)
The news correspondents report that additional information may be obtained from S. Bharti, Govt India, Cent Council Res Unani Med, Minist Hlth & Family Welf, New Delhi 110058, India (see also Diet and Nutrition).
Keywords for this news article include: Asia, Antioxidants, India, Ischemia, New Delhi, Reperfusion, Medical Devices, Blood Transfusion, Protective Agents, Diet and Nutrition, Transfusion Medicine
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