~ Soy Consumption Reduces Men's PSA Levels

A diet rich in soy may reduce levels of serum prostate-specific antigen (PSA) without reducing testosterone levels, according to a new study conducted by researchers from the Cancer Research Center of Hawaii and published on line by European Journal of Clinical Nutrition, June 14, 2006. Low prostate cancer incidence and high soy intake in Asian countries suggests a possible protective effect of soy foods against prostate cancer.

Twenty-four men with an average age 58 (+ or - 7.2 years) were randomized into two study groups. One group received a high-soy diet (two servings per day) and the other a low-soy (normal) diet for three months. After a one-month washout period, the groups crossed over to the other treatment for an additional three months. Blood was drawn from each subject four times and urine collected five times during the study. Samples were analyzed for serum testosterone and PSA by radioimmunoassay. Compliance was assessed by calendars, dietary recalls and urinary isoflavone excretion.

During the high-soy diet, dietary isoflavone intake and urinary isoflavone excretion increased significantly compared to the low-soy diet. A 14% decline in serum PSA was seen during the high-soy period, with no changes in testosterone. In addition, compliance with the intervention was high, based on dietary calendars and blood tests, demonstrating the feasibility of the intervention.

SOY BENEFITS MEN AND WOMEN

Soy isoflavones are often considered a women�s supplement. A Recent R&D Update covered a study which found that soy isoflavones benefited immune system function of women in menopause. This study shows that soy can be just as important for men. Whole soy foods such as tofu and soymilk contain approximately 35 to 40 mg of soy isoflavones per � cup serving. R&D Soy Isoflavones provides 40 mg of isoflavones per capsule, with all naturally occurring soy saponins and other soy trace nutrients. One capsule twice daily provides a significant soy component to the diet.

Soy isoflavones are a class of phytoestrogens, plant compounds similar to estrogen, which are capable of binding and modulating cellular estrogen receptor cites. Soy isoflavones may exert a hormone normalizing effect in pre and postmenopausal women. Its action is determined by a woman�s endogenous estrogen levels. In the presence of excessive estrogen (e.g. PMS), isoflavones exercise an antiestrogenic effect by competing with estrogen for receptor cites. Conversely, as estrogen levels decline in menopause, isoflavones provide a mild estrogenic activity. The hormone modulating effects of soy isoflavones may be beneficial in menopause, endometriosis, cervical dysplasia, menstrual irregularities, and breast cancer prevention.

Soy isoflavones may inhibit or even reverse osteoporotic changes in menopausal women. Isoflavones are thought to help preserve bone density by a direct estrogenic action on osteoblastic cells, but may also aid by reducing osteoclastic activity. A number of studies, clinical and epidemiological, indicate that soy isoflavones may reduce risk of a number of types of cancer including hormone dependant cancers (breast and prostate) as well as certain other cancers including colon, lung and leukemia. Several mechanisms have been suggested including inhibition of tumor promoting enzymes and inhibition of tumor angiogenesis. The substitution of soy for animal protein has long been accepted as a dietary strategy for hypercholesterolemia and heart disease.

More recently the soy isoflavone genistein has been found to play an important role in inhibiting platelet activation, thrombin formation and smooth muscle cell proliferation, which lead to the formation of atherosclerotic plaque. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat or prevent any disease.

C 2006 Werum Enterprises, Inc.


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