~ Research on Diabetes Discussed by Investigators at University of Navarra

~ Research on Diabetes Discussed by Investigators at University of Navarra
By a News Reporter-Staff News Editor at Diabetes Week -- Current study results on Diabetes have been published. According to news reporting from Pamplona, Spain, by NewsRx journalists, research stated, "Vitamin K has been related to glucose metabolism, insulin sensitivity and diabetes. Because inflammation underlies all these metabolic conditions, it is plausible that the potential role of vitamin K in glucose metabolism occurs through the modulation of cytokines and related molecules."

The news correspondents obtained a quote from the research from the University of Navarra, "The purpose of the study was to assess the associations between dietary intake of vitamin K and peripheral adipokines and other metabolic risk markers related to insulin resistance and type 2 diabetes mellitus. Cross-sectional and longitudinal assessments of these associations in 510 elderly participants recruited in the PREDIMED centers of Reus and Barcelona (Spain). We determined 1-year changes in dietary phylloquinone intake estimated by food frequency questionnaires, serum inflammatory cytokines and other metabolic risk markers. In the cross-sectional analysis at baseline no significant associations were found between dietary phylloquinone intake and the rest of metabolic risk markers evaluated, with exception of a negative association with plasminogen activator inhibitor-1. After 1-year of follow-up, subjects in the upper tertile of changes in dietary phylloquinone intake showed a greater reduction in ghrelin (-15.0%), glucose-dependent insulinotropic peptide (-12.9%), glucagon-like peptide-1 (-17.6%), IL-6 (-27.9%), leptin (-10.3%), TNF (-26.9%) and visfatin (-24.9%) plasma concentrations than those in the lowest tertile (all p<0.05)."

According to the news reporters, the research concluded: "These results show that dietary phylloquinone intake is associated with an improvement of cytokines and other markers related to insulin resistance and diabetes, thus extending the potential protection by dietary phylloquinone on chronic inflammatory diseases."

For more information on this research see: Association between dietary phylloquinone intake and peripheral metabolic risk markers related to insulin resistance and diabetes in elderly subjects at high cardiovascular risk. Cardiovascular Diabetology, 2013;12():1-9. Cardiovascular Diabetology can be contacted at: Biomed Central Ltd, 236 Grays Inn Rd, Floor 6, London WC1X 8HL, England. (BioMed Central - www.biomedcentral.com/; Cardiovascular Diabetology - www.cardiab.com)

Our news journalists report that additional information may be obtained by contacting M. Juanola-Falgarona, University of Navarra, Dept. of Prevent Med & Public Hlth, E-31080 Pamplona, Spain (see also Diabetes).

Keywords for this news article include: Spain, Europe, Pamplona, Diabetes, Cytokines, Cardiology, Proinsulin, Cardiovascular, Hyperinsulinism, Peptide Hormones, Insulin Resistance, Glucose Metabolism Disorders, Nutritional and Metabolic Diseases

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