~ Recent Attack on DHEA Based on One Flawed Study - References

References

1. Nair KS, Rizza RA, O'Brien P, et al. DHEA in elderly women and DHEA or testosterone in elderly men. N Engl J Med. 2006 Oct 19;355(16):1647-59.

2. Villareal DT, Holloszy JO. Effect of DHEA on abdominal fat and insulin action in elderly women and men: a randomized controlled trial. JAMA. 2004 Nov 10;292(18):2243-8.

3. Villareal DT, Holloszy JO. DHEA enhances effects of weight training on muscle mass and strength in elderly women and men. Am J Physiol Endocrinol Metab. 2006 Nov;291(5):E1003-E1008.

4. Schmidt PJ, Daly RC, Bloch M, et al. Dehydroepiandrosterone monotherapy in midlife-onset major and minor depression. Arch Gen Psychiatry. 2005 Feb;62(2):154-62.

5. Kawano H, Yasue H, Kitagawa A, et al. Dehydroepiandrosterone supplementation improves endothelial function and insulin sensitivity in men. J Clin Endocrinol Metab. 2003 Jul;88(7):3190-5.

6. Feldman HA, Johannes CB, Araujo AB, et al. Low dehydroepiandrosterone and ischemic heart disease in middle-aged men: prospective results from the Massachusetts Male Aging Study. Am J Epidemiol. 2001 Jan 1;153(1):79-89.

7. Dr. Melton reports having received lecture fees from Amgen, Merck, Novartis, and Procter & Gamble. Dr. Nehra reports having served as a consultant to Pfizer. No other potential conflict of interest relevant to this article was reported.

8. von Muhlen D, Laughlin GA, Kritz-Silverstein D, et al. The Dehydroepiandrosterone And WellNess (DAWN) study: Research design and methods. Contemp Clin Trials. 2006 May 6; [Epub ahead of print]

9. Magri F, Cravello L, Barili L, et al. Stress and dementia: the role of the hypothalamicpituitary-adrenal axis. Aging Clin Exp Res. 2006 Apr;18(2):167-70. Review.

10. Martin-Du Pan R. [Prevention of cardiovascular and degenerative diseases: II. Hormones and/or Mediterranean diet] Rev Med Suisse Romande. 2003 Mar;123(3):183-9. Review.

11. Rommler A. [Adrenopause and dehydroepiandrosterone: pharmacological therapy versus replacement therapy] Gynakol Geburtshilfliche Rundsch. 2003 Apr;43(2):79-90.

12. Fingerova H, Matlochova J. [Reduced serum dehydroepiandrosterone levels in postmenopausal osteoporosis] Ceska Gynekol. 1998 Apr;63(2):110-3.

13. Hampl R, Starka L. [Dehydroepiandrosterone, "the youth hormone", in the light of recent findings] Cas Lek Cesk. 1998 Jan 12;137(1):8-12. Review.

14. Feldman HA, Johannes CB, Araujo AB, et al. Low dehydroepiandrosterone and ischemic heart disease in middle-aged men: prospective results from the Massachusetts Male Aging Study. Am J Epidemiol. 2001 Jan 1;153(1):79-89.

15. Piedrola G, Novo E, Serrano-Gotarredona J, et al. Relationship between insulin sensitivity and dehydroepiandrosterone sulfate in patients with ischemic heart disease. Horm Metab Res. 1997 Nov;29(11):566-71.

16. Barrett-Connor E, Goodman-Gruen D. Dehydroepiandrosterone sulfate does not predict cardiovascular death in postmenopausal women. The Rancho Bernardo Study. Circulation. 1995 Mar 15;91(6):1757-60.

17. Nordmark G, Bengtsson C, Larsson A, et al. Effects of dehydroepiandrosterone supplement on health-related quality of life in glucocorticoid treated female patients with systemic lupus erythematosus. Autoimmunity. 2005 Nov;38(7):531-40.

18. Meyer P, Meier CA. [Focus on dehydroepiandrosterone (DHEA)] Rev Med Suisse. 2005 Feb 9;1(6):415-8.

19. Cameron DR, Braunstein GD. The use of dehydroepiandrosterone therapy in clinical practice. Treat Endocrinol. 2005;4(2):95-114. Review.

20. Chen CC, Parker CR Jr. Adrenal androgens and the immune system. Semin Reprod Med. 2004 Nov;22(4):369-77. Review.

21. Chang DM, Chu SJ, Chen HC, et al. Dehydroepiandrosterone suppresses interleukin 10 synthesis in women with systemic lupus erythematosus. Ann Rheum Dis. 2004 Dec;63(12):1623-6.

22. Hartkamp A, Geenen R, Godaert GL, et al. The effect of dehydroepiandrosterone on lumbar spine bone mineral density in patients with quiescent systemic lupus erythematosus. Arthritis Rheum. 2004 Nov;50(11):3591-5.

23. Petri MA, Mease PJ, Merrill JT, et al. Effects of prasterone on disease activity and symptoms in women with active systemic lupus erythematosus. Arthritis Rheum. 2004 Sep;50(9):2858-68.

24. Hernandez-Morante JJ, Milagro F, Gabaldon JA, et al. Effect of DHEA-sulfate on adiponectin gene expression in adipose tissue from different fat depots in morbidly obese humans. Eur J Endocrinol. 2006 Oct;155(4):593-600.

25. Rabijewski M, Kozakowski J, Zgliczynski W. [The relationship between testosterone and dehydroepiandrosterone sulfate concentrations, insulin resistance and visceral obesity in elderly men] Endokrynol Pol. 2005 Nov-Dec;56(6):897-903.

26. Savastano S, Belfiore A, Guida B, et al. Role of dehydroepiandrosterone sulfate levels on body composition after laparoscopic adjustable gastric banding in pre-menopausal morbidly obese women. J Endocrinol Invest. 2005 Jun;28(6):509-15.

27. Straub RH, Konecna L, Hrach S et al. Serum DHEA and DHEA-S are negatively correlated with serum IL-6, and DHEA inhibits secretion from mononuclear cells in man in vitro: possible link between endocrinosenescence and immunosenescence. J Clin Endocrinol Metab 1998; 83:2012-17.

28. Arlt W, Callies F, van Vlijmen JC, et al. DHEA replacement in women with adrenal insufficiency. N Engl J Med 1999; 341:1013-20.

29. Hayashi T et al. DHEA retards atherosclerosis formation through its conversion to estrogens: the possible role of nitric oxide. Arterioscler Thromb Vasc Biol 2000; 20: 782-92.

30. Hunt PJ, Gurnell EM, Huppert FA, et al. Improvement in mood and fatigue after DHEA replacement in Addison’s disease in a randomized, double-blind trial. J Clin Endocrinol Metab 2000; 85:4650-56.

31. Murialdo G, Nobili F, Rollero A, et al. Hippocampal perfusion and pituitary-adrenal axis in Alzheimer’s disease. Neuropsychobiology 2000; 42:51-57.

32. Padgett DA, Loria RM, Sheridan JF. Steroid hormone regulation of antiviral immunity. Ann N Y Acad Sci 2000; 917:935-43.

33. Straub RH, Scholmerich J, Zietz B. Replacement therapy with DHEA plus corticosteroids in patients with chronic inflammatory diseases--substitutes of adrenal and sex hormones. Z Rheumatol. 2000;59 Suppl 2:II/108-18.


Free Shipping in the Continental U.S. on Orders over $50
The statements made here have not been evaluated by the FDA. The foregoing statements are based upon sound and reliable studies, and are meant for informational purposes. Consult with your medical practitioner to determine the underlying cause of your symptoms. Please always check your purchase for possible allergins and correct dosage on the bottle before use.

While we work to ensure that product information is correct, on occasion manufacturers may alter their ingredient lists. Actual product packaging and materials may contain more and/or different information than that shown on our Web site. We recommend that you do not solely rely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. For additional information about a product, please contact the manufacturer. Content on this site is for reference purposes and is not intended to substitute for advice given by a physician, pharmacist, or other licensed health-care professional. You should not use this information as self-diagnosis or for treating a health problem or disease. Contact your health-care provider immediately if you suspect that you have a medical problem. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease or health condition. Life Ex Online assumes no liability for inaccuracies or misstatements about products.