By M Saraswathi, Bernama, 09-28-05
PETALING JAYA, Sept 27 (Bernama) -- The first evidence that palm
tocotrienol, an extract from palm oil may protect against stroke injury of
brain, was revealed at the International Palm Oil Congress (PIPOC) by
Vitamin E researcher, Professor Chandan K Sen.
He said that neuroprotective (brain health) benefits of palm
tocotrienol dietary supplement is a new discovery and links the supplement
to more and diverse uses.
Findings from Sen's latest research studies showed that even short term
dietary intake of palm tocotrienol is readily absorbed by major organs -
the brain, the heart, the lungs and the skin.
In the past, other forms of dietary tocotrienol did not manage to reach
the major organs and dampened research in tocotrienol as a dietary
supplement, he said in a statement released today at PIPOC 2005, being held
Vitamin E is a family of related compounds known as tocopherols and
tocotrienols and these compounds have been linked to health benefits such
as reducing the risk of cardiovascular disease and cancer, boosting immune
system function and acting as an antioxidant.
The research study conducted by Sen was funded by a research grant in
excess of US$1.2 million (about RM4.51 million) from the National Institute
of Neurological Disorders & Stroke, a division under the US National
Institute of Health.
Sen is the Director of the Laboratory of Molecular Medicine, Director
of the DNA Microarray & Genetics facility of the Davis Heart & Lung
Research Institute, and Director of the Ohio State Comprehensive Wound
Center at the Ohio State University Medical Center.
In laboratory trials conducted by Sen and reported in the Journal of
Biological Chemistry, alpha-tocotrienol was found to be much more potent
than the regular alpha-tocopherol found in most Vitamin E preparations, in
protecting brain cells from glutamate-induced toxicity.
Tocotrienol was also found to cross the blood-brain barrier and
protects neurons, conferring protection against stroke.
"Study results on the neuroprotective properties of palm tocotrienol
are encouraging and we hope to conduct large-scale clinical trials," Sen
"Attention to the naturally occurring tocotrienols, especially to their
neuroprotective properties, can provide us with a powerful tool to combat
neurodegeneration especially stroke, by safe dietary means," said Sen, who
noted that the general misconception is that tocopherols are the only
vitamin E molecules in nature.
Tocotrienols are concentrated in cereal grains such as oat, barley, and
rye, rice bran, with the richest source found in fruits of palms, such as
locally grown oil palms.
Palm tocotrienol is patented by a Malaysian company, Carotech Bhd, and
marketed internationally by another Malaysian company, Hovid Bhd. Its
registered trademark is Tocomin.
Tocomin is manufactured by Carotech Bhd and is commercially available
as nutritional supplement that is 50 percent tocotrienol, the statement
It is the main ingredient found in Tocovid SupraBio 50mg and 200mg
manufactured by Hovid Bhd that is available in leading pharmacies
Vist http://www.transdatacorp.com, for more info, email firstname.lastname@example.org.