~ October 2007 - Novel Turmeric Compound Delivers Much More Curcumin to the Blood

Contents . . .
  • Novel Turmeric Compound Delivers Much More Curcumin to the Blood

    By Dale Kiefer

    Life Extension readers have long been aware of the vast array of health benefits conferred by the curry spice turmeric, which is the source of curcumin. Scientific researchers around the world are investigating applications for curcumin that include fighting cancer, arthritis, diabetes, cardiovascular disease, osteoporosis, and reversing the pathological processes underlying Alzheimer's disease, among other conditions.1-13

    Curcumin has long been known to have poor bioavailability, requiring high doses to achieve desired blood levels. A novel curcumin absorption system has been developed that delivers up to seven times more pharmacologically bioactive curcumin to the blood compared with commercial curcumin products.

    A wealth of data shows that curcumin and its related chemicals (collectively known as curcuminoids) help to prevent and fight a wide range of diseasesfrom cancer to cardiovascular diseasethrough a variety of mechanisms. These include powerful anti-inflammatory, antioxidant, chemopreventive (cancer-preventive), and antineoplastic (cancer-fighting) properties.

    Perhaps one of curcumin's most important activities in the human body is its ability to inhibit activation of the transcription factor, nuclear factor-kappa B (NF-kB),4-6 a potent inducer of chronic inflammation. NF-kB is a protein that acts as a sort of switch, turning on inflammation by activating genes involved in the production of inflammatory compounds.

    As NF-kB activation has been implicated in all the stages of carcinogenesis, this transcription factor is a potential target in cancer chemoprevention and is the subject of intensive research.

    Read more . . .
  • Adult Stem Cells: New Hope for Curing Degenerative Diseases

    By Denis Rodgerson, PhD, Ron Rothenberg, MD, FACEP, and Wayne A. Marasco, MD, PhD

    The potential to heal once incurable degenerative diseases such as cancer or heart disease by regenerating cells that have failed or are about to fail is now within our grasp, thanks to the emergence of an exciting new field of medicine: regenerative medicine using adult stem cells.

    Indeed, tissues such as heart muscle that were long thought to be non-renewable have now been shown to be regenerated through this novel therapy. By using adult stem cells, scientists have avoided the controversy that has stymied advanced embryonic stem cell research in the past. Adult stem cell therapy offers an unprecedented step forward in the history of medicine and the applications of this new form of regenerative medicine are potentially unlimited.

    Embryonic versus Adult Stem Cells

    Considerable confusion surrounds the use of stem cells, not only with the general public, but indeed with scientists and physicians. This confusion has been compounded by the ethical, moral, and political issues that have arisen around the sources of stem cells.

    Broadly speaking, there are two classifications of stem cells: those that are derived from embryos (embryonic stem cells, ESCs) and those that come from other sources (adult stem cells [ASCs] or somatic stem cells). All stem cells, whatever their source, have three general properties: they are capable of dividing and renewing themselves for long periods; they are undifferentiated; and they have the ability to develop into specialized cell types.

    Read more . . .
  • The Intimate Link Between Erectile Dysfunction and Heart Disease

    By William Davis, MD

    In the early years of my cardiology practice, I was surprised by the number of men with heart disease who also suffered from impotence. In fact, being incapable of having an erection was the norm rather than the exception after heart attack. In those days, impotence was widely attributed to the psychological depression that often followed heart attack.

    But closer questioning often revealed a very different story--men would admit that struggles to achieve an erection usually preceded a heart attack or other cardiac event by one, two, or three years. Back then, the pattern of erectile dysfunction and cardiac disease was so widespread, that most in the medical profession attributed it to simple "aging," as common as wrinkles and constipation.

    Today, we know that a convergence of findings relates male impotence -- called erectile dysfunction (ED) -- with heart disease. The two conditions are varied expressions of a common phenomenon, and are surprisingly similar. If you have one, you're likely to have the other.

    Powerful clinical and scientific experience suggests a close link between erectile dysfunction and heart disease. Studies like the Health Professionals Follow-up Study have revealed the risk factors for erectile dysfunction to be very similar to those for heart disease. Hypertension, smoking, diabetes, high cholesterol, obesity, and physical inactivity all strongly predict sexual dysfunction in men, as they do heart disease.

    The Massachusetts Male Aging Study of 1,290 men, aged 40-70 years, has documented the extraordinarily high prevalence of erectile dysfunction among aging men: 50% of men at 50 years of age, and 70% by age 70 have erectile dysfunction. Furthermore, a recent Italian study of men with severe heart disease has uncovered an astounding 93% with erectile dysfunction 24 months before their heart attack or onset of heart disease symptoms.

    As many of us failed to recognize years earlier, these studies reveal that erectile dysfunction and coronary disease are, in many respects, one and the same. The risks are identical, the paths to both are largely the same, though the immediate consequences are different.

    Read more . . .
  • Fighting Depression and Improving Cognition with Omega-3 Fatty Acids

    By Laurie Barclay, MD

    Antidepressant drugs continue to raise concerns about their side effects, which include suicide, clinical worsening of depression, and unusual changes in behavior in adolescents and children.

    Recently, the FDA instructed all drug manufacturers to add black box warnings (the most serious warning label for a prescription medicine) to their antidepressant drugs.

    In light of these findings, doctors and patients are seeking safer alternative therapies. New research reveals that omega-3 fatty acids may effectively alleviate depression without dangerous side effects.

    In this article, we unveil the growing evidence base for omega-3s in improving mood and restoring structural integrity to brain cells that are critical in performing cognitive functions.

    Already well known for their ability to protect against heart disease, cancer, and diabetes, the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) may be highly effective in preventing and managing depression and cognitive decline, according to a growing body of evidence.

    The American Psychiatric Association's treatment recommendations for the use of omega-3 fatty acids bears testament to this strategy. Joseph R. Hibbeln, MD, from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) tells Life Extension magazine, "The strongest evidence was found for managing major depressive symptoms, with the effect of omega-3s being at least as great, if not greater than, antidepressant medications." Regarding these powerful fatty acids, Dr. Hibbeln further notes, "deficient intakes may increase risk for mental distress."

    Read more . . .
  • Featured Product: Super Bio-Curcumin

    Curcumin was first used by Indians over 3000 years ago in traditional Ayurvedic medicine. Modern science has found that this extract from the common spice turmeric has remarkable qualities as an antioxidant. Over time, as our cells continue to be affected by free radicals, or oxidants, organs begin to degenerate and aging accelerates. The body has built-in defense mechanisms to protect itself from free radical damage, but eventually, aging depletes the body’s ability to keep oxidants at bay.

    Curcumin can also help maintain normal healthy platelet function and the normal process of bile excretion.

    New studies have tied inflammation to overexpression of a protein molecule called nuclear factor-kappa beta (NFkB). NFkB acts like a switch to turn on genes that produce the body's inflammatory responses. Because NFkB's expression increases in aging adults, scientists have sought ways to modulate NFkB and its effects in the body.

    Curcumin has been shown to exert powerful effects within the body, Curcumin inhibits overexpression of NFkB and acts on substances that activate NFkB. For example, by binding iron and copper in brain tissue, curcumin reduces NFkB activation.

    Curcumin's multifaceted effects include protecting against estrogen-mimicking chemicals, protecting against damaging free radicals, and promoting normal cell cycle growth.

    The 100% natural curcuminoids complex in Super Bio Curcumin® is a patent-pending synergistic blend of curcuminoids and sesquiterpenoids with enhanced bioavailability and sustained retention time in the body confirmed by human clinical studies. Super Bio-Curcumin® is a "next generation" in delivery of curcumin compounds that no longer requires high doses of curcumin to reach sustainable levels of curcumin in the blood plasma. Each 400 mg capsule of Super Bio-Curcumin® is equivalent to 2772 mg of a typical 95% curcumin extract.
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