~ November 2005 - Lose Weight by Fighting Inflammation

Contents . . .
  • Dr. Perricone's Weight Loss Program

    By Nicholas V. Perricone, MD

    Scientists are rapidly acknowledging the role of inflammation in many diseases and chronic conditions. Subclinical, microscopic, invisible inflammation is responsible for a great number of metabolic problems, resulting in accelerated aging, serious health threats, unwanted weight gain, and obesity.

    If this was not bad enough news for adults, there is now alarming new evidence that this diet-related inflammation is also causing weight gain and obesity in young children and adolescents, resulting in diseases and conditions such as type II diabetes and metabolic syndrome, which normally do not manifest until much later in life.

    My research has shown that the chief therapeutic intervention to prevent weight gain (regardless of age) is the anti-inflammatory diet. I have observed significant weight loss in thousands of individuals who follow the simple formula of avoiding foods that are pro-inflammatory and choosing in their place foods with anti-inflammatory properties.

    What is of particular interest to me is the fact that the same foods (those with anti-inflammatory properties) that fight many diseases, aging, sagging skin, and wrinkling, also cause significant weight loss—and they are safe for everyone, children and adults alike. At the same time, the foods that accelerate aging and put us at risk for disease and the loss of cognitive abilities (the pro-inflammatory foods) also cause weight gain. These foods and beverages also interfere with the body's natural ability to metabolize foods properly, making it increasingly difficult to lose unwanted weight.

    Perhaps the worst dietary craze belongs to the 1980s, which heralded the age of the no-fat diet. Supermarket shelves were flooded with high-glycemic carbohydrate foods, offering little in the way of nutrients, but plenty in the way of empty calories. These foods became dietary mainstays for many people, especially women, who found themselves indulging in snack foods such as reduced-fat "baked" potato and corn chips, and fat-free rice and corn cakes, cookies, pretzels, and crackers. Suddenly millions of Americans were placing themselves in a chronic inflammatory condition. Why? Because eating these foods provokes a pro-inflammatory rapid rise in blood sugar, resulting in elevated insulin levels.

    Read more about how inflammation affects weight and overall health . . .

    Nutritional Factors in Weight Gain and Loss . . .
  • Alcohol - A Deadly Carcinogen

    By Dale Kiefer

    People associate excess alcohol ingestion with liver cirrhosis and brain cell damage. Alcohol, however, inflicts a more insidious effect. Epidemiological studies clearly show that those who consume large amounts of alcohol have sharply increased risks of certain cancers.

    Especially troubling are esophageal and brain cancers, both of which are increasing in frequency at an alarming rate. In women, even moderate alcohol consumption is linked with higher breast cancer incidence.

    In this article, we reveal what most of the public does not know about the carcinogenic effects of excess alcohol ingestion. We then provide some guidance as to what one may do to reduce alcohol's damaging effects.

    Read the full article . . .
  • A New Weapon to Fight Prostate Cancer

    By Dale Kiefer

    Scientists recently uncovered a novel component of milk thistle that may be a powerful new weapon for preventing and possibly even treating prostate cancer. This phytochemical, called isosilybin B, potently suppresses the growth and runaway proliferation of human prostate cancer cells. Isosilybin B also suppresses the activity of a genetic factor that is expressed in most human cancers. Moreover, this potent phytonutrient inhibits the secretion of a protein that may contribute to prostate cancer progression and metastasis.

    Importantly, isosilybin B is active against both hormone-dependent and hormone-independent prostate cancers. Isosilybin B may thus offer the most powerful protection against prostate malignancies of any phytonutrient yet discovered.

    Read the full article . . .
  • Can Green Tea Protect Against Prostate Cancer?

    By Coulson K. Duerksen

    In recent years, a growing body of research has established the many health-promoting benefits of green tea, which may include protection against coronary heart disease, stroke, osteoporosis, infections, and other conditions.

    Laboratory and epidemiological studies suggest that this long-valued beverage may help prevent and manage certain cancers. Last year, for example, an article published in the prestigious British medical journal The Lancet (and reprinted in the January 2005 issue of Life Extension) noted that a review of green tea's effects on human leukemia cells "provides a strong scientific basis for the chemopreventive property of green tea that has been inferred from several epidemiological studies."

    According to The Lancet article, "the importance of nutraceuticals in cancer prevention and treatment remains largely under-exploited despite increasing evidence showing that these molecules have chemopreventive and chemotherapeutic ability . . . Green tea and other diet-derived compounds . . . offer several advantages as anti-cancer products, because these compounds are non-toxic, produce few side effects, are widely available, and are cheap."

    Despite mounting evidence of green tea's cancer-preventive effects published in prestigious medical journals, the FDA recently denied a petition that would have allowed companies that make green tea products to include a health claim on their product labels. The proposed health claim would have advised consumers that green tea, when ingested at certain levels, helps fight cancer. While the petitioner cited 135 studies in support of the proposed health claim, the FDA's "systematic review" considered only certain human studies while ignoring the other evidence.

    Read the full article . . .
  • Columbia University Study Suggests Benefits of Zyflamend (R) in the Early Treatment of Prostate Cancer

    NEW YORK, Nov 07, 2005 (BUSINESS WIRE) -- Data from the Columbia University Department of Urology demonstrates that Zyflamend(R), a unique herbal extract preparation, suppresses the growth of prostate cancer cells and induces prostate cancer cells to self-destruct via a process called "apoptosis." The data, published in the October edition of Nutrition and Cancer, showed Zyflamend(R), a patented formulation from New Chapter, has the ability, in vitro, to reduce prostate cancer cell proliferation by as much as 78 percent and to induce cancer cell death or apoptosis.

    The research confirms Zyflamend(R) has COX-1 and COX-2 anti-inflammatory effects, although its anti-cancer affects against prostate cancer were independent of COX-2 inhibition, supporting the postulation that some prostate cancer cells are not affected by COX-2 inflammation.

    "These results were particularly surprising and show great promise in the fight against prostate cancer," said researcher Dr. Debra L. Bemis of the Columbia University Department of Urology. "We hope that the magnitude of benefits shown in this research will be confirmed in the larger scale trial already in progress."

    Read the full article . . .
  • Featured Product: Mega Silymarin with Isosilybin B - Milk thistle extract has long been valued for its role in ensuring healthy liver function. Milk thistle extract consists of silibinin and other similar compounds. Until recently, researchers believed that silibinin was the most biologically active ingredient found in milk thistle extract.

    Highly advanced extraction technology has now enabled scientists to isolate silymarin constituents and to test their efficacy against various cell lines. Among the compounds tested, a silymarin constituent called isosilybin B proved to be the most efficient in maintaining healthy cell division.1

    New Mega Silymarin with Isosilybin B is the first milk thistle extract to contain standardized, pharmaceutical grade potencies of silymarin, silibinin and isosilybin B - providing the full spectrum of milk thistle's liver and prostate protective compounds.

    Supplement Facts

    Serving Size: 1 capsule

    Servings Per Container: 100

    Amount Per Serving
    • Milk Thistle Extract (Silybum marianum) [standardized to 80% Silymarin by UV (720 mg), 30% Silibinin by HPLC (270 mg), and 4.5% Isosilybin B by HPLC (40.5 mg)] - 900 mg


    Other ingredients: gelatin, rice flour, magnesium stearate, silica. This product contains NO wheat, yeast, gluten, soy, or dairy. Contains NO artificial sweeteners, flavors, colors, or preservatives.

    Dosage and Use: Take one capsule daily or as recommended by a healthcare practitioner. This product can be taken with or without food.

    Notes: 1 Davis-Searles PR, Nakanishi Y, Kim NC. Cancer Research. 2005 May 15;65(10):4448-57.
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