~ More Evidence For Soy Isoflavones In Bone Loss Protection

D Dye, Life Extension

A study published online on June 8, 2006 in the European Journal of Nutrition revealed an association between reduce bone loss in postmenopausal women and consumption of isoflavones derived from soy germ, adding more evidence to protective benefits that have been found for soy against osteoporosis.

Investigators at Sun Yat-sen University in Guangzhou, China randomly assigned 90 nonobese postmenopausal women between the ages of 45 and 60 years to receive 84 or 126 milligrams soy isoflavones, or a placebo for 6 months. The study utilized higher doses of isoflavones than those that have produced inconsistent effects in previous bone loss prevention trials of postmenopausal women.

Bone mineral density of the spine and hip, and serum osteocalcin and bone-specific alkaline phosphatase, which are markers of bone formation, were measured at the beginning of the study and at its conclusion.

After six months, bone mineral density at the lumbar spine and femoral neck of the hip increased in the groups who received soy isoflavones, with those who received the higher dose experiencing a greater increase. No significant changes in serum osteocalcin and bone specific alkaline phosphatase were observed.

Jocelyn Mathern, RD, who is a technical specialist at Acatris, the company that supplied the soy isoflavones stated, "It is imperative to find natural, safe and effective alternatives for women to help maintain bone health after menopause without the risky side effects associated with long-term hormone replacement therapy use. This promising research is another step in advancing soy germ isoflavones as a safe, effective option."

"We are awaiting results of a large study, the Osteoporosis Prevention Using Soy (OPUS) study, a multisite, two year research study on the use of soy isoflavones to prevent bone loss in 400 postmenopausal women," she added.


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