~ May 2006 - New Insights on Hearts and Minds

Contents . . .
  • Restoring Brain Cell Function

    By Russell Martin

    Over the past 10 years, scientific studies have revealed the remarkable effects that fish consumption has on neurological function.

    For instance, in both middle-aged and older study subjects, cognitive decline occurs less frequently in those who eat the most fish. In elderly subjects, the risk of dementia is reduced in those consuming as little as one fish meal a week. Even in children, a deficiency of the fatty acids found in fish is associated with learning disorders.

    The omega-3 fatty acids in fish oil are vital to brain cell structure and function. Based on the brain's critical need for omega-3 fatty acids, scientists have developed a compound that takes the DHA found in fish oil and binds it to a lecithin extract that has been shown to reduce the risk of cognitive dysfunction in the elderly.

    Laboratory studies document that this patented compound delivers higher DHA concentrations to brain cells. When humans with learning disabilities consumed this DHA-lecithin extract for three months, the clinical response was 2.4 times greater compared to placebo.

    There have been numerous recent studies that offer new approaches on how best to restore brain function and prevent cognitive decline.

    Read more about these important findings . . .
  • Hidden Cardiac Risk Factors

    By William Faloon

    Despite significant advances in heart attack prevention over the past 35 years, cardiac disease remains the leading cause of death in the Western world. Conventional medical doctors routinely prescribe drugs that reduce potentially dangerous cholesterol and low-density lipoprotein (LDL) while sometimes boosting beneficial high-density lipoprotein (HDL). Although more people take cardiac drugs than ever before, hundreds of thousands of Americans still perish each year from heart failure while under a doctor’s care.

    New members often ask us why their coronary arteries continue to narrow even when they have followed all the steps their cardiologist has prescribed. The answer is that atherosclerosis has multiple underlying causes. Unless every one of these risk factors is corrected, aging adults will continue to suffer epidemic levels of vascular diseases, including heart attack and stroke.

    Life Extension long ago uncovered cardiac risks that mainstream doctors ignore. Recent scientific studies have validated that atherosclerosis is indeed a multifactorial process, and that taking aggressive preventive actions can dramatically reduce one’s chances of dying from cardiovascular disease.

    Read more . . .
  • New Blood Test better Predicts Heart Attack

    By William Davis, MD, FACC

    Marc, a successful architect, had rigorously monitored his cholesterol levels every six months since his mother’s difficult recovery from a coronary bypass operation at the age of 63.

    Over the years, Marc’s low-density lipoprotein (LDL), a component of a standard cholesterol panel, wavered within a narrow range that never exceeded 95 milligrams per deciliter (mg/dL). “Your cholesterol profile is excellent, as always,” his family doctor declared.

    Nevertheless, a heart attack struck Marc down without warning at the age of 54, leaving him breathless and exhausted from performing the most ordinary activities. Demoralized and frightened, Marc pressed his doctor to explain why he had a heart attack despite his excellent cholesterol values. “Marc, some people have heart attacks because of genetics,” his doctor replied. “There’s not a whole lot we can do about that.”

    If you ask your doctor whether heart disease lurks silently within you, chances are your doctor will have no idea. Too often, an attempt will be made to predict your future by evaluating standard cholesterol tests. As a result, your risk, like Marc’s, may be frightfully misjudged.

    The shocking reality is that heart disease is the number one killer of men and women in the US, yet most physicians have no idea how to diagnose the presence of hidden heart disease. If you go to an emergency room having suffered a heart attack, the doctor will usually make the correct diagnosis. But most heart disease is silent and unsuspected. The first symptom is often the last: sudden death. If you rely on your doctor to detect hidden heart disease, you may not get an accurate assessment. It does not have to be this way.

    Read more . . .
  • Nutritional Strategies for Preventing Age Related Vision Loss

    By Edward Rosick, DO, MPH, MS

    By the age of 65, a shocking 30% of Americans suffer from drastic vision problems that are not correctable with glasses or contact lenses. The two most common causes of vision loss in older adults are cataracts and age-related macular degeneration.

    While millions of doctors and their patients view these insidious conditions as inevitable consequences of the aging process, Life Extension has long maintained that potent antioxidants can play a critical role in supporting healthy ocular function with aging.

    Mainstream medicine is finally recognizing the critical link between eye health and nutrition. Recent articles in prestigious scientific publications such as the Journal of the American Medical Association and Ophthalmology verify the importance of antioxidant nutrients in preserving vision. Moreover, emerging studies indicate that suppressing levels of potentially dangerous C-reactive protein and homocysteine is likewise essential to maintaining eye health with aging.

    Health-conscious adults can thus preserve their vision by using targeted nutritional remedies and managing the risk factors that directly threaten eye health. This well-rounded, preventive approach can help ensure healthy vision over the course of a lifetime.

    The sense of sight is a wondrous gift of nature that begins at the moment of birth and ideally lasts a lifetime. As we age, however, both the lens and retina of the eye may suffer deterioration that can lead to near or even total blindness. Such problems affect nearly one third of elderly adults. Two of the most common eye diseases afflicting the elderly are cataracts and age-related macular degeneration.

    Read more . . .
  • Butterbur Extract - Effective, Drug-Free Allergy Relief

    By Russell Martin

    For hay fever sufferers, European clinical studies have demonstrated that butterbur, a flowering herb, can be as effective as the leading allergy drugs Zyrtec® and Allegra®.

    This represents a remarkable breakthrough for all allergy patients—they can now be free of the debilitating side effects of traditional antihistamines used to treat allergies, including palpitations, severe drowsiness, and fatigue.

    Additional research has identified rosmarinic acid as an aid in normalizing the inflammation and immune response that accompany allergic reactions. Together, these two botanical agents offer great relief for many of the nearly 40 million Americans now suffering from allergic rhinitis (hay fever).

    Butterbur: Herbal Help from Europe

    Butterbur has a long history of medicinal applications throughout Europe.

    As early as the Middle Ages, butterbur root — Petasites hybridus — was used to alleviate infections and fevers. Later, the herb was used in Europe, northern Africa, and Asia to treat coughs, congestion, and asthma. Butterbur's principal active constituents include petasin and isopetasin, phytochemicals that may reduce spasms in smooth muscle and relax swollen nasal membranes. The active ingredients in butterbur inhibit leukotriene synthesis, consistent with butterbur's anti-spasm and anti-inflammatory properties.

    In the last 30 years, a standardized preparation of butterbur has been recognized as an effective treatment for hay fever in Europe, where herbal remedies must undergo rigorous testing before they can be used by the general public. Repeated studies have shown that butterbur (standardized for petasin and isopetasin) dramatically improves breathing and reduces the effects of histamine and nasal congestion, all without side effects. Let's take a look at some of these remarkable findings.

    Read more . . .
  • Featured Product: Cognitex with Neuroprotection Complex - Cognitex has been reformulated and changed from a softgel to a hard capsule to take advantage of new developments and ingredients for cognitive health. The previous Cognitex formulas provided premium levels of phospholipids nutrients (GPC and PS), vinpocetine and pregnenolone (option). This has been maintained while adding "next generation" nutrients and more vinpocetine for advanced brain protection.

    We also offer Cognitex with Pregnenolone & Neuroprotection Complex

    More Protection Against Free Radicals

    The brain is a highly active organ that produces high levels of free radicals from normal metabolism. These free radicals can bombard the fatty membranes of neurons and other brain cells causing premature loss of function. Cognitex contains a number of phytonutrient-based antioxidants that work best in a lipid (fat) rich environment like the brain.

    Ingredients That Work Hard For You

    While antioxidant nutrients provide essential free radical protection, many have limited capacity once they have spared an electron to balance a free radical. Cognitex now contains a novel rosemary extract that is rich in carnosic acid, which provides multistep protection against free radicals in a process called the carnosic acid cascade. At each step of free radical interaction a new compound is formed, which in turn is a powerful antioxidant in itself.

    Bioavailable to the Brain

    Nutritional support for the brain is more challenging as a barrier called the blood-brain barrier keeps out toxins but also competing nutrients and drugs. Cognitex contains the grape seed extract Leucoselect® Phytosome™. By pairing one molecule of proanthocyanidins from grape seed extract with two molecules of phosphatidylcholine from soy lecithin in the Phytosome™, the uptake and distribution to target tissues of the grape seed polyphenols is enhanced. Once in the brain, the polyphenols trap dangerous hydroxyl free radicals that turn fat rancid. These fats make up the outer lipid membrane of trillions of brain cells. These polyphenols also protect blood circulation and oxygen flow to the brain by improving the tone and elasticity of blood vessels.

    Molecular Size Matters

    High level of procyanidins from grape seed extract does not ensure an extract is going to have a beneficial effect on the body. Polyphenols with higher molecular weight cannot be absorbed. Leucoselect® Phytosome™ contains smaller size molecules for advanced therapeutic activity as the larger molecules are discarded during the extraction process.

    A Difference You Can Feel

    Taking dietary supplements can often be an act of faith as we often cannot feel what they are doing. Cognitex contains GPC and phosphatidylserine that improve neural function at the functional level over time. New to Cognitex is the patented, nonstimulant phytonutrient called Sensoril®. Sensoril® is a proprietary standardized extract of ashwagandha, also know as "Indian ginseng", and used in Ayurvedic traditional medicine for boosting brain function and alleviating mental fatigue. Advanced extraction practices now allows for a highly concentrated yet balanced brain nutrient. The effects can often be felt immediately with greater alertness and focus but without the jitteriness of stimulants.

    Mind Your Brain and Body

    Sensoril® also helps modulate the stress response resulting in cortisol excretion. Stress can be very damaging to the brain, especially memory function, and cortisol stimulates the body to release sugar (glucose) into the bloodstream. Elevated levels of glucose can accelerate aging and increase fat storage leading to weight gain, especially in the abdomen. In addition, the stress-modulating abilities of Sensoril® can help stress overeaters especially when it comes to carbohydrate cravings.

    Advanced and Safe Inflammation Protection

    Cognitex now contains a new Neuroprotection Complex designed to provide highly concentrated standardized extracts of hops, ginger and rosemary – known anti-inflammatory nutrients.

    IsoOxygene® is a new phytonutrient derived from the hops plant, that is beginning to be used in nutritional formulas in high dosages for inflammatory conditions. Cognitex uses a lower dose to address the low-grade inflammation occurring in the brain. How IsoOxygene® stands out from a myriad of anti-inflammatory compounds, including drugs, is that it is highly selective to COX-2 inhibition versus COX-1. The COX-2:COX-1 ratio for IsoOxygene® is 30:1 compared to about 2:1 for the majority of botanical and drug COX inhibitors. Studies on IsoOxygene® are on-going to determine levels of 5-LOX inhibition.

    Circulation Is Key To Memory

    Brain cells such as neurons are fed by blood vessels. Some of these microcapillaries can be so small that red blood cells carrying oxygen have difficulty passing through them. Neurons are the key structure for cognitive functions including memory. Vinpocetine enhances blood flow by dilating blood vessels and reducing blood viscosity. Vinpocetine enhances cerebral metabolism by improving blood flow, increasing glucose and oxygen utilization by neurons and concentration of neurotransmitters involved in memory formation.

    Supplement Facts

    Serving Size: 3 capsules

    Servings Per Container: 30

    Amount Per Serving
    • Glyceryl Phosphoryl Choline (GPC) - 600 mg
    • Phosphatidylserine - 100 mg
    • Vinpocetine - 20 mg
    • Phosphatidylcholine-Grape Seed Extract [Contains 50 mg of Leucoselect®
    • Phytosome™ grape seed extract (95% polyphenols) bound to 100 mg of phosphatidylcholine from soy] - 150 mg
    • Sensoril® Ashwagandha (Withania somnifera) Extract (root and leaves) [standardized to 8% withanolide glycoside conjugates (10 mg) and 32% oligosaccharides (40 mg)] - 125 mg
    • Proprietary NeuroProtection Complex Blend - 125 mg
    • IsoOxygene® Hops (Humulus Iupulus) Extract (aerial parts) (standardized to 30% alpha and iso-alpha acids)
    • Ginger (Zingiber officinale) Extract (root) (standardized to 5% gingerols by HPLC)
    • Rosemary (Rosmarinus officinalis) Extract (leaves) (standardized to 20% diterpenic compounds)
    Other ingredients: dicalcium phosphate, silicon dioxide, magnesium stearate, gelatin.

    Leucoselect® is a registered trademark of Indena S.p.A. Phytosome™ is a trademark of Indena S.p.A. This product contains IsoOxygene®, manufactured by Pharmachem Laboratories, Inc. IsoOxygene® is a registered trademark. Sensoril® is protected under US Patents Nos. 6,153,198 and 6,713,092 and is a registered trademark of Natreon, Inc.

    Dosage and Use: Take three capsules in the morning with or without food. Some people may take three capsules twice daily or as recommended by a health care practitioner.

    Note: For some, taking this new Cognitex can cause hours of alertness so it may not be advisable to take near bedtime. Also, Sensoril® is an "adpatogenic" herb and like all adaptogens are effective by bringing balance within the body.

    Someone who is mentally exhausted and needs rest may find that initial use of this product may bring on a feeling of needing to sleep. This is normal and the body is responding to the need for rest. Continued use of the product will bring on mental reinvigoration.
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