~ Mar 07 Growing Evidence Links Resveratrol to Extended Life Span - References

References for "Growing Evidence Links Resveratrol to Extended Life Span"

1. Ingram DK, Anson RM, de Cabo R, et al. Development of calorie restriction mimetics as a prolongevity strategy. Ann NY Acad Sci. 2004 Jun;1019:412-23.

2. Sinclair DA. Toward a unified theory of caloric restriction and longevity regulation. Mech Ageing Dev. 2005 Sep;126(9):987-1002.

3. Valenzano DR, Terzibasi E, Genade T, et al. Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate. Curr Biol. 2006 Feb 7;16(3):296-300.

4. Heilbronn LK, de Jonge L, Frisard MI, et al. Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial. JAMA. 2006 Apr 5;295(13):1539-48.

5. Baur JA, Pearson KJ, Price NL, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature. 2006 Nov 16;444(7117):337-42.

6. Available at: http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/res_0224.shtml. Accessed January 10, 2007.

7. Lagouge M, Argmann C, Gerhart-Hines Z, et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell. 2006 Dec 15;127(6):1109-22.

8. Kaeberlein M, McDonagh T, Heltweg B, et al. Substrate-specific activation of sirtuins by resveratrol. J Biol Chem. 2005 Apr 29;280(17):17038-45.

9. Borra MT, Smith BC, Denu JM. Mechanism of human SIRT1 activation by resveratrol. J Biol Chem. 2005 Apr 29;280(17):17187-95.

10. Guarente L, Picard F. Calorie restriction—the SIR2 connection. Cell. 2005 Feb 25;120(4):473-82.

11. Porcu M, Chiarugi A. The emerging therapeutic potential of sirtuin-interacting drugs: from cell death to lifespan extension. Trends Pharmacol Sci. 2005 Feb;26(2):94-103.

12. Constant J. Alcohol, ischemic heart disease, and the French paradox. Coron Artery Dis. 1997 Oct;8(10):645-9.

13. Folts JD. Potential health benefits from the flavonoids in grape products on vascular disease. Adv Exp Med Biol. 2002;505:95-111.

14. Bujanda L, Garcia-Barcina M, Gutierrez-de JV, et al. Effect of resveratrol on alcohol-induced mortality and liver lesions in mice. BMC Gastroenterol. 2006 Nov 14;6:35.

15. Sovak M. Grape extract, resveratrol, and its analogs: a review. J Med Food. 2001;4(2):93-105.

16. Ignatowicz E, Baer-Dubowska W. Resveratrol, a natural chemopreventive agent against degenerative diseases. Pol J Pharmacol. 2001 Nov;53(6):557-69.

17. Fremont L. Biological effects of resveratrol. Life Sci. 2000 Jan 14;66(8):663-73.

18. Bhat KPL, Kosmeder JW, Pezzuto JM. Biological effects of resveratrol. Antioxid Redox Signal. 2001 Dec;3(6):1041-64.

19. Wang Z, Huang Y, Zou J, et al. Effects of red wine and wine polyphenol resveratrol on platelet aggregation in vivo and in vitro. Int J Mol Med. 2002 Jan;9(1):77-9.

20. Olas B, Wachowicz B. Resveratrol and vitamin C as antioxidants in blood platelets. Thromb Res. 2002 Apr 15;106(2):143-8.

21. Olas B, Wachowicz B, Saluk-Juszczak J, Zielinski T. Effect of resveratrol, a natural polyphenolic compound, on platelet activation induced by endotoxin or thrombin. Thromb Res. 2002 Aug 15;107(3-4):141-5.

22. Brito PM, Mariano A, Almeida LM, Dinis TC. Resveratrol affords protection against peroxynitrite-mediated endothelial cell death: A role for intracellular glutathione. Chem Biol Interact. 2006 Dec 15;164(3):157-66.

23. Novakovic A, Bukarica LG, Kanjuh V, Heinle H. Potassium channels-mediated vasorelaxation of rat aorta induced by resveratrol. Basic Clin Pharmacol Toxicol. 2006 Nov;99(5):360-4.

24. Kim H, Deshane J, Barnes S, Meleth S. Proteomics analysis of the actions of grape seed extract in rat brain: technological and biological implications for the study of the actions of psychoactive compounds. Life Sci. 2006 Mar 27;78(18):2060-5.

25. Mokni M, Limam F, Elkahoui S, Amri M, Aouani E. Strong cardioprotective effect of resveratrol, a red wine polyphenol, on isolated rat hearts after ischemia/reperfusion injury. Arch Biochem Biophys. 2007 Jan 1;457(1):1-6.

26. Goh SS, Woodman OL, Pepe S, et al. The red wine antioxidant resveratrol prevents cardiomyocyte injury following ischemia-reperfusion via multiple sites and mechanisms. Antioxid Redox Signal. 2007 Jan;9(1):101-13.

27. Chen WP, Su MJ, Hung LM. In vitro electrophysiological mechanisms for antiarrhythmic efficacy of resveratrol, a red wine antioxidant. Eur J Pharmacol. 2007 Jan 12;554(2-3):196-204.

28. Dong Z. Molecular mechanism of the chemopreventive effect of resveratrol. Mutat Res. 2003 Feb;523-524:145-50.

29. Aggarwal BB, Bhardwaj A, Aggarwal RS, et al. Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Res. 2004 Sep;24(5A):2783-840.

30. Trincheri NF, Nicotra G, Follo C, Castino R, Isidoro C. Resveratrol induces cell death in colorectal cancer cells by a novel pathway involving lysosomal cathepsin D. Carcinogenesis. 2006 Nov 20.

31. Heynekamp JJ, Weber WM, Hunsaker LA, et al. Substituted trans-stilbenes, including analogues of the natural product resveratrol, inhibit the human tumor necrosis factor alpha-induced activation of transcription factor nuclear factor KappaB. J Med Chem. 2006 Nov 30;49(24):7182-9.

32. Vigna GB, Costantini F, Aldini G, et al. Effect of a standardized grape seed extract on low-density lipoprotein susceptibility to oxidation in heavy smokers. Metabolism. 2003 Oct;52(10):1250-7.

33. Vinson JA, Proch J, Bose P. MegaNatural((R)) gold grapeseed extract: in vitro antioxidant and in vivo human supplementation studies. J Med Food. 2001;4(1):17-26.

34. Olas B, Wachowicz B, Majsterek I, et al. Antioxidant properties of trans-3,3',5,5'-tetrahydroxy-4'-methoxystilbene against modification of variety of biomolecules in human blood cells treated with platinum compounds. Nutrition. 2006 Nov;22(11-12):1202-9.

35. Martin AR, Villegas I, La CC, de la Lastra CA. Resveratrol, a polyphenol found in grapes, suppresses oxidative damage and stimulates apoptosis during early colonic inflammation in rats. Biochem Pharmacol. 2004 Apr 1;67(7):1399-410.

36. Richard N, Porath D, Radspieler A, Schwager J. Effects of resveratrol, piceatannol, tri-acetoxystilbene, and genistein on the inflammatory response of human peripheral blood leukocytes. Mol Nutr Food Res. 2005 May;49(5):431-42.

37. Elmali N, Baysal O, Harma A, Esenkaya I, Mizrak B. Effects of resveratrol in inflammatory arthritis. Inflammation. 2006 Nov 4.

38. Savaskan E, Olivieri G, Meier F, et al. Red wine ingredient resveratrol protects from beta-amyloid neurotoxicity. Gerontology. 2003 Nov;49(6):380-3.

39. Marambaud P, Zhao H, Davies P. Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides. J Biol Chem. 2005 Nov 11;280(45):37377-82.

40. Wang J, Ho L, Zhao Z, et al. Moderate consumption of cabernet sauvignon attenuates abeta neuropathology in a mouse model of Alzheimer's disease. FASEB J. 2006 Nov;20(13):2313-20.

41. Anekonda TS. Resveratrol—a boon for treating Alzheimer's disease? Brain Res Brain Res Rev. 2006 Sep;52(2):316-26.

42. Luo L, Huang YM. Effect of resveratrol on the cognitive ability of Alzheimer's mice. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2006 Aug;31(4):566-9.

43. Sharma M, Gupta YK. Chronic treatment with trans resveratrol prevents intracerebroventricular streptozotocin induced cognitive impairment and oxidative stress in rats. Life Sci. 2002 Oct 11;71(21):2489-98.

44. Kumar P, Padi SS, Naidu PS, Kumar A. Effect of resveratrol on 3-nitropropionic acid-induced biochemical and behavioural changes: possible neuroprotective mechanisms. Behav Pharmacol. 2006 Sep;17(5-6):485-92.

45. Harper JM, Salmon AB, Chang Y, et al. Stress resistance and aging: influence of genes and nutrition. Mech Ageing Dev. 2006 Aug;127(8):687-94.

46. De Santi C, Pietrabissa A, Spisni R, Mosca F, Pacifici GM. Sulphation of resveratrol, a natural compound present in wine, and its inhibition by natural flavonoids. Xenobiotica. 2000 Sep;30(9):857-66.

47. De Santi C, Pietrabissa A, Spisni R, Mosca F, Pacifici GM. Sulphation of resveratrol, a natural product present in grapes and wine, in the human liver and duodenum. Xenobiotica. 2000 Jun;30(6):609-17.

48. Hayashi A, Gillen AC, Lott JR. Effects of daily oral administration of quercetin chalcone and modified citrus pectin on implanted colon-25 tumor growth in Balb-c mice. Altern Med Rev. 2000 Dec;5(6):546-52.

49. Prokop J, Abrman P, Seligson AL, Sovak M. Resveratrol and its glycon piceid are stable polyphenols. J Med Food. 2006;9(1):11-4.

50. Available at http://www.news.cornell.edu/releases/Feb98/Resveratrol.bpf.html. Accessed January 18, 2007.

51. Bettuzzi S, Brausi M, Rizzi F, et al. Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study. Cancer Res. 2006 Jan 15;66(2):1234-40.

52. Rezai-Zadeh K, Shytle D, Sun N, et al. Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice. J Neurosci. 2005 Sep 21;25(38):8807-14.

References for "What Dose of Resveratrol Should Humans Take?"

1. Baur JA, Pearson KJ, Price NL, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature. 2006 Nov 16;444(7117):337-42.

2. Ingram DK, Zhu M, Mamczarz J, et al. Calorie restriction mimetics: an emerging research field. Aging Cell. 2006 Apr;5(2):97-108.

3. Zhang J. Resveratrol inhibits insulin responses in a SirT1-independent pathway. Biochem J. 2006 Aug 1;397(3):519-27.

4. Bauer JH, Goupil S, Garber GB, Helfand SL. An accelerated assay for the identification of lifespan-extending interventions in Drosophila melanogaster. Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):12980-5.

5. Wood JG, Rogina B, Lavu S, et al. Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature. 2004 Aug 5;430(7000):686-9.

6. Kent S. Life Extension's visionary plan to conquer aging and death. Life Extension. January, 2006:54-65.

7. Mitchell T. Broad-spectrum effects of grape seed extract. Life Extension. July, 2005:32-9.

8. Oliff HS. Uncontrolled high blood pressure: a little-known failure of conventional medicine. Life Extension. August, 2006:30-36.

9. Kiefer D. Preserving and restoring brain function. Life Extension. October, 2005:36-45.

10. Martin R. Novel strategy to restore brain cell function. Life Extension. May, 2006:24-31.

11. Wagner E. Grape seed extract promotes bone formation. Life Extension. October, 2006:24.

12. Dye D. Grape seed blocks colon cancer cell growth. Life Extension. January, 2007:13.

13. Available at: http://www.news.cornell.edu/releases/Feb98/Resveratrol.bpf.html. Accessed January 18, 2007.


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