~ Low Total Vitamin C Plasma Level Is Risk Factor for Hemodialysis Patients
"Hemodialysis patients are prone to deficiency of vitamin C, which constitutes the most abundant nonenzymatic antioxidant in blood. Because antioxidants are involved in the pathogenesis of atherosclerosis, the authors examined the association of total vitamin C plasma level with cardiovascular outcomes in such patients," scientists writing in the Journal of the American Society of Nephrology reported in the Journal of the American Society of Nephrology.
According to R. Deicher and colleagues at the Medical University of Wien, "One hundred thirty-eight consecutive maintenance hemodialysis patients (median age 61 years, 90 males) were enrolled in a single-center study. At baseline, routine laboratory parameters were recorded, and predialysis total vitamin C plasma levels were measured by high-pressure liquid chromatography. Patients were prospectively followed-up for the occurrence of a primary composite endpoint consisting of fatal and nonfatal major adverse cardiovascular events (MACE) and for all-cause and cardiovascular mortality."
Study data revealed, "MACE occurred in 35 patients (25%) over a period of median 30 mo, and 42 patients (30%) died [29 cardiovascular deaths (21% of total)]. Using Cox proportional hazards modeling, adjusted hazard ratios for the occurrence of MACE were 3.90 (95% confidence interval [CI]: 1.42 to 10.67; p=0.008) and 3.03 (95% CI: 1.03 to 8.92; p=0.044) for patients in the lower (60 mc mol/L). Hazard ratios for cardiovascular death were 3.79 (95% CI: 1.23 to 11.66; p=0.020) and 2.89 (95% CI: 0.89 to 9.37; p=0.076). Total vitamin C levels were not independently associated with all-cause mortality."
"This study concludes that low total vitamin C plasma levels predict adverse cardiovascular outcomes among maintenance hemodialysis patients. Future studies should address the potential protective effect of an adequate vitamin C supplementation," wrote Deicher's team.
Deicher and colleagues published their study in the Journal of the American Society of Nephrology (Low total vitamin C plasma level is a risk factor for cardiovascular morbidity and mortality in hemodialysis patients. J Am Soc Nephrol, 2005;16(6):1811-1818).
Additional information can be obtained by contacting R. Deicher, Med University of Wien, Innere Med Klin 3, Klin Abt Nephrology & Dialyse, Wahringer Gurtel 18-20, A-1090 Vienna, Austria.
The publisher of the Journal of the American Society of Nephrology can be contacted at: Lippincott Williams & Wilkins, 530 Walnut St., Philadelphia, PA 19106-3621, USA.
This article was prepared by Cardiovascular Week editors from staff and other reports. Copyright 2005, Cardiovascular Week via NewsRx.com.
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