~ Low Intakes of Vitamin D and Certain Flavonoids Were Predictors of AMI, Stroke

NewsRx.com, 08-26-05

Researchers have investigated dietary and serum vitamins and minerals as predictors of myocardial infarction and stroke in elderly subjects.

Investigators writing in the journal Nutrition Metabolism and Cardiovascular Diseases report, "According to a widespread hypothesis, antioxidative vitamins and trace elements may protect the body against atherosclerotic diseases, especially in the elderly. We assessed dietary and serum vitamins and minerals for prediction of acute myocardial infarction (AMI) and stroke in elderly subjects."

J. Marniemi and colleagues of the National Public Health Institute in Turku explained, "In a population-based health survey with special emphasis on the diet, subjects aged 65-99 years were followed up for up to 10 years. The study population consisted of 361 men and 394 women. Information on individual food consumption was elicited by means of dietary history interviews. Serum vitamins and mineral elements were analyzed utilizing commonly applied biochemical methods."

They continued, "Prediction analyses were based on 130 cases accumulated in the AMI group, 70 subjects in the stroke group, and corresponding control subjects. The cases were determined on the basis of revised information from the National Register of Cases of Death, and from the National Hospital Discharge Register."

"Low intake of vitamin D (p=0.011) and low serum levels of 1,25-dihydroxy-vitamin D (p=0.0053) were significantly predictive of stroke when adjusted for age, gender, smoking and functional capacity," the researchers reported. "On the other hand, high dietary intakes of two flavonoids, luteolin (p=0.0096) and kaempferol (p=0.002) were associated with lowered risk of AMI. Furthermore, low serum levels of iron predicted both AMI (p=0.013) and stroke (p=0.019). The results remained essentially unchanged when adjusted for additional major risk factors of atherosclerosis."

"From the items in the dietary interview, low intakes of vitamin D and certain flavonoids emerged as the sole predictors of AMI and stroke. In biochemical analyses, on the other hand, these disorders were predicted only by low levels of 1,25-dihydroxy-vitamin D and iron in the serum," they noted.

Marniemi and colleagues published their study in Nutrition Metabolism and Cardiovascular Diseases (Dietary and serum vitamins and minerals as predictors of myocardial infarction and stroke in elderly subjects. Nutr Metab Cardiovasc Dis, 2005;15(3): 188-197).

For additional information, contact J. Marniemi, National Publ Health Institute, Department Health & Functioning Capac, Peltolantie 3, FIN-20720 Turku, Finland.

The publisher's contact information for the journal Nutrition Metabolism and Cardiovascular Diseases is: Elsevier Science Ltd., the Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England.

Keywords: Turku, Finland, Angiology, Atherosclerosis, Cardiology, Cardiovascular, Cardiovascular Disease, Diet and Nutrition, Elderly, Epidemiology, Flavonoids, Geriatric, Heart Attack, Metabolism, Myocardial Infarction, Stroke, Vitamin D, Atherosclerosis Risk Factors. This article was prepared by Biotech Week editors from staff and other reports. Copyright 2005, Biotech Week via NewsRx.com.

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