~ July 2004 - How to Protect Against Chronic Inflammation

Table of Contents . . .

  • Help for Those Who Suffer from Chronic Inflammation - Inflammation is a causative factor in the development of heart attacks, cancer, stroke, and Alzheimer's disease, along with autoimmune disorders such as lupus, multiple sclerosis, and asthma.

    With this issue, get a better understanding of what inflammation is, how it affects the body, and what you can do to prevent inflammation from robbing you of your good health for years to come.


  • Powerful Anti-Inflammatories

    Lysozome Plus is a proteolytic enzyme formula and COX 2 inhibitor used for treating systemic inflammation.

    Inflammation is the body's protective response to trauma, however, it produces pain and delays healing. Inflammation begins with increased capillary permeabiliy, then plasma infiltrates the soft tissue of the trauma where plasma proteins denature and congeal, resulting in edema.

    Protein digesting enzymes attack and break down denatured inflammation and promote healing through restoration of circulation to the injury. The same mechanism supports reduction of arthritic inflammation caused by arthritis, Lupus and other auto-immune inflammatory conditions.

    ArthroPro - Multiple degenerative processes occur due to agents that promote systemic inflammation. These inflammatory agents include, cyclooxygenase-2 (COX-2), 5-lipooxygenase (5-LOX), and damaging cytokines known as tumor necrosis factor alpha (TNF-a) and interleukin-1 beta (IL-1b). Other harmful enzymes are collagenase and phospholipase. The purpose of this formula is to block all the destructive pathways involved.

    BetaMax - Beta glucan targets inflammation associated with infection. It is an immune enhancer and antioxidant that increases lymphocytes and macrophage production. Because it is anti-microbial, it is helpful in prevention and treatment of a wide range of bacterial, fungal, parasitic and viral infections. Beta glucan protects against radiation exposure and UV damage from sun exposure.

    Chronoforte - Chronoforte addresses the underlying causes that accelerate the aging process and bring about age-related diseases. Aging causes damage to proteins such as carbonylation (protein oxidation) and glycation (protein-sugar cross-linking). Aging also causes mitochondrial energy to diminish and age-associated low level systemic inflammatory reactions to become pronounced. In addition, aging can cause imbalances in levels of blood glucose, resulting in systemic damage throughout the body.

    Natural Prostate Formula - The four herbal extracts contained in Natural Prostate Formula include two powerful anti-inflammatories: nettle and pygeum. In addition to its ability to have antihistamine-like effect, nettles tonify and firm inflamed tissues. Pygeum, which has anti-inflammatory properties, has been shown to alleviate symptoms associated with benign prostate enlargement.

    Cognitex - Cognitex is twice as strong as before, now containing cox 2 inhibitors and natural agents that block the brain's dual inflammatory pathways, improving circulation and restoring acetylcholine. Inflammation is associated with cognitive deficit such as memory decline and "senility". GPC's mechanism of action resembles the action of donepezil (Aricept) and rivastigimine (Exelon), presently prescried in this country to combat Alzheimer's and vascular dementia patients.

    Super Carnosine - Aging causes irreversible damage to the body's proteins. The underlying mechanism behind this damage is glycation. A simple definition of glycation is the cross-linking of proteins and sugars to form non-functioning structures in the body. The process of glycation can be superficially seen as unsightly wrinkled skin. Glycation is also an underlying cause of age-related catastrophes including the neurologic, vascular, and eye disorders. Carnosine is a unique dipeptide that interferes with the glycation process. When compared to the anti-glycating drug aminoguanidine, carnosine has been shown to inhibit glycation earlier in the process and also provides additive health benefits.

    Zyflamend - Zyflamend is an effective anti-inflammatory appropriate to use with or without glucosamine. Anti-inflammatories help the glucosamine's ability to enter the cells. Zyflamend inhibits the COX-2 enzyme and reduces inflammation, promotes healthy joint function, promotes normal cell growth, and contains organic herbal anti-aging constituents that inactivate free-radicals.


  • Featured Product - Chronoforte - Addressing the underlying causes that accelerate the aging process and bring about age-related diseases. Aging causes damage to proteins such as carbonylation (protein oxidation) and glycation (protein-sugar cross-linking). Aging also causes mitochondrial energy to diminish and age-associated low level systemic inflammatory reactions to become pronounced. In addition, aging can cause imbalances in levels of blood glucose, resulting in systemic damage throughout the body.

    The multi-nutrient, ChronoForte, is newly formulated with the addition of benfotiamine. This ingredient provides synergistic action against the destructive processes associated with maturation. The formula includes:

    Carnosine - A multifunctional dipeptide made up of a chemical combination of the amino acids beta-alanine and L-histidine. It is found both in food and in the human body. Carnosine interferes with the destructive mechanisms of carbonylation and glycation, thus keeping protein healthy.

    L-carnitine - An amino acid that helps to maintain cellular energy metabolism by assisting in the transport of fat through the cell membrane and into the mitochondria within the cell, where these fats are oxidized to produce the cellular energy ATP. Acetyl-L-carnitine is the acetyl ester of the amino acid L-carnitine and is absorbed into the bloodstream more efficiently than L-carnitine, passes more easily through cell membranes, and is utilized more efficiently in the mitochondria of the cell.

    Alpha lipoic acid - A unique fat- and water-soluble antioxidant with broad-spectrum health-promoting benefits. In combination with acetyl-L-carnitine, alpha lipoic acid can help maintain mitochondrial function, resulting in improved cellular energy. Alpha lipoic acid is also a key enzymatic energy co-factor and can boost levels of glutathione, the body’s natural antioxidant.

    The herbal extract, nettle leaf, that helps to maintain normal levels of TNF-a, IL-1B, and 1L-6 believed to contribute to the destructive cascade that can affect almost every system in the body, including a healthy immune system.

    Benfotiamine - A fat-soluble form of vitamin B1 (thiamine) that helps to guard cells against the negative effects of glucose. Elevated glucose can lead to damage of the endothelial lining of the blood vessels, retina, and kidneys.

    The flavonoid, quercetin, helps to maintain a normal balance of nuclear factor kappa B and stabilizes mast cells. Quercetin helps promote healthy blood flow and blocks the accumulation of the carbohydrate, sorbital, that can lead to neural tissue damage.

    Zinc - Also included because of its effect in lowering infection and cancer.


  • Chronic Inflammation - The Culprit Behind Many Serious Disease Conditions - For the past 16 years, Life Extension has been warning of the dangers of systemic chronic inflammation. We revealed that inflammation is a causative factor in the development of heart attacks, cancer, stroke, and Alzheimer's disease, along with autoimmune disorders such as lupus, multiple sclerosis, and asthma.

    The cover of the February 23, 2004, issue of TIME magazine is titled, "The Silent Killer... The surprising link between Inflammation and Heart Attacks, Cancer, Alzheimer's and other diseases." According to the TIME article, the recognition of inflammation's role in disease causation "could radically change doctors' concept of what makes us sick."

    Most doctors view inflammation through the lens of its textbook definition: a part of the body's defense against bacteria and viruses. Inflammation is also involved in the normal healing process.

    What scientists are learning, however, is that aged people often lose the ability to "turn off" inflammatory reactions. This problem also occurs in younger people as a result of genetic factors or bad health habits such as poor diet, cigarette smoking, and obesity. In these cases, inflammation becomes "chronic" rather than transitory. The result is that the body's immune system constantly attacks the arteries, brain cells, and joint cartilage, along with every organ system.

    Read more . . .


  • Quenching the Flames of Chronic Inflammation - The flames of a small fire are easy to put out. Once the fire has spread, however, it begins to feed itself . . . destroying everything in its path . . . and becomes extremely difficult to extinguish.

    The same is true of chronic inflammation. In its early stages, it can be suppressed using a variety of lifestyle changes, nutrients, and sometimes drugs. Once systemic inflammation takes hold, however, immune cells release dangerous cytokines in a vicious cycle that destroys tissues throughout the body. In response to this tissue destruction, even more inflammatory cytokines (such as interleukin-6) are produced incessantly because the body thinks it is under attack.

    Yet even with all the weapons in our armamentarium, we still encounter difficult cases where the production of inflammatory cytokines cannot be suppressed.

    Read more . . .


  • Protocol: Chronic Inflammation - Chronic systemic inflammation is an underlying cause of many seemingly unrelated, age-related diseases. As humans grow older, systemic inflammation can inflict devastating degenerative effects throughout the body (Ward 1995; McCarty 1999; Brod 2000). This fact is often overlooked by the medical establishment, yet persuasive scientific evidence exists that correcting a chronic inflammatory disorder will enable many of the infirmities of aging to be prevented or reversed.

    The pathological consequences of inflammation are well documented in the medical literature (Willard et al. 1999; Hogan et al. 2001). Regrettably, the dangers of systemic inflammation continue to be ignored, even though proven ways exist to reverse this process. However, by following specific prevention protocols, the inflammatory cascade can be significantly reduced.

    The Causes of Age-Related Inflammation

    Aging results in an increase of inflammatory cytokines (destructive cell-signaling chemicals) that contribute to the progression of many degenerative diseases (Van der Meide et al. 1996; Licinio et al. 1999). Rheumatoid arthritis is a classic autoimmune disorder in which excess levels of cytokines such as tumor necrosis factor-alpha (TNF-a), interleukin-6 (IL-6), interleukin 1b [IL-1(b)], and/or interleukin-8 (IL-8) are known to cause or contribute to the inflammatory syndrome (Deon et al. 2001).

    Chronic inflammation is also involved in diseases as diverse as atherosclerosis, cancer, heart valve dysfunction, obesity, diabetes, congestive heart failure, digestive system diseases, and Alzheimer's disease (Brouqui et al. 1994; Devaux et al. 1997; De Keyser et al. 1998). In aged people with multiple degenerative diseases, the inflammatory marker, C-reactive protein, is often sharply elevated, indicating the presence of an underlying inflammatory disorder (Invitti 2002; Lee et al. 2002; Santoro et al. 2002; Sitzer et al. 2002). When a cytokine blood profile is conducted on people in a weakened condition, an excess level of one or more of the inflammatory cytokines, e.g., TNF-a, IL-6, IL-1(b), or IL-8, is usually found (Santoro et al. 2002).

    Protecting Against Inflammatory-Related Disease

    The New England Journal of Medicine published several studies in the year 2000 showing that the blood indicators of inflammation are strong predictive factors for determining who will suffer a heart attack (Lindahl et al. 2000; Packard et al. 2000; Rader 2000).

    A growing consensus among scientists is that common disorders such as atherosclerosis, colon cancer, and Alzheimer's disease are all caused in part by a chronic inflammatory syndrome.

    Seemingly unrelated diseases have a common link. People who have multiple degenerative disorders often exhibit excess levels of pro-inflammatory markers in their blood.

    A critical inflammatory marker is C-reactive protein. This marker indicates an increased risk for destabilized atherosclerotic plaque and abnormal arterial clotting. When arterial plaque becomes destabilized, it can burst open and block the flow of blood through a coronary artery, resulting in an acute heart attack.

    One of the New England Journal of Medicine studies showed that people with high levels of C-reactive protein were almost three times as likely to die from a heart attack (Ridker et al. 1997).

    The Life Extension Foundation long ago advised members to have an annual C-reactive protein blood test to detect systemic inflammation that could increase the risk of heart attack, stroke, cancer and a host of age-related diseases.

    In January of 2003, the American Heart Association and Centers for Disease Control & Prevention (CDC) jointly endorsed the C-reactive protein test to screen for coronary-artery inflammation to identify those at risk for heart attack.

    Read more about what you can do to prevent and treat chronic inflammation . . .


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