~ Jul 10 Unleash Your Skin's Internal Defenses - References


1. Middelkamp-Hup M, Pathak MA, Parrado C, et.al. Oral Polypodium leucotomos extract decreases ultraviolet-induced damage of human skin. J Am Acad Dermatol. 2004 Dec;51(6):910-8.

2. González S, Pathak MA, Cuevas J, Villarrubia VG, Fitzpatrick TB. Topical or oral administration with an extract of Polypodium leucotomos prevents acute sunburn and psoralen-induced phototoxic reactions as well as depletion of Langerhans cells in human skin. Photodermatol Photoimmunol Photomed. 1997 Feb-Apr;13(1-2):50-60.

3. Gonzalez S, Gilaberte Y, Philips N. Mechanistic insights in the use of a Polypodium leucotomos extract as an oral and topical photoprotective agent. Photochem Photobiol Sci. 2010 Apr;9(4):559–63.

4. Rogers HW, Weinstock MA, Harris AR, et al. Incidence estimate of nonmelanoma skin cancer in the United States, 2006. Arch Dermatol. 2010 Mar; 146(3): 283-7.

5. Available at: http://www.medscape.com/viewarticle/470300_2. Accessed May 3, 2010.

6. NutraGenesis LLC. Data on file. 2008.

7. Horvath A, Alvarado F, Szöcs J, de Alvardo ZN, Padilla G. Metabolic effects of calagualine, an antitumoral saponine of Polypodium leucotomos. Nature.1967 Jun 17; 214(5094):1256-8.

8. Caccialanza M, Percivalle S, Piccinno R, Brambilla R. Photoprotective activity of oral polypodium leucotomos extract in 25 patients with idiopathic photodermatoses. Photodermatol Photoimmunol Photomed. 2007 Feb;23(1):46-7.

9. Philips N, Conte J, Chen YJ, et al. Beneficial regulation of matrixmetalloproteinases and their inhibitors, fibrillar collagens and transforming growth factor-beta by Polypodium leucotomos, directly or in dermal fibroblasts, ultraviolet radiated fibroblasts, and melanoma cells. Arch Dermatol Res. 2009 Aug;301(7):487-95.

10. Eberlein-Konig B, Placzek M, Przybilla B. Protective effect against sunburn of oral combined systemic ascorbic acid (vitamin C) and D-alpha-tocopherol (vitamin E). J Am Acad Dermatol.1998 Jan;38(1):45-8.

11. Stahl W, Sies H. Carotenoids and flavonoids contribute to nutritional protection against skin damage from sunlight. Mol Biotechnol. 2007 Sep;37(1):26-30.

12. Sies H, Stahl W. Nutritional protection against skin damage from sunlight. Annu Rev Nutr. 2004;24:173-200.

13. Villa A, Viera M, Amini S, et al. Decrease of ultraviolet A light–induced "common deletion" in healthy volunteers after oral Polypodium leucotomos extract supplement in a randomized clinical trial. J Am Acad Dermatol. 2010 Mar;62(3);511-3.

14. Greul AK, Grundmann JU, Heinrich F, et al. Photoprotection of UV-irradiated human skin: an antioxidative combination of vitamins E and C, carotenoids, selenium, and proanthocyanidins. Skin Pharmacol Appl Skin Physiol. 2002 Sep-Oct;15(5):307-15.

15. Stahl W, Heinrich U, Jungmann H, Sies H, Tronnier H. Carotenoids and carotenoids plus vitamin E protect against ultraviolet light-induced erythema in humans. Am J Clin Nutr. 2000 Mar;71(3):795-8.

16. Palombo P, Fabrizi G, Ruocco V, et al. Beneficial long-term effects of combined oral/topical antioxidant treatment with the carotenoids lutein and zeaxanthin on human skin: a double-blind, placebo-controlled study. Skin Pharmacol Physiol. 2007;20(4):199-210.

17. Buljan D, Buljan M, Zivković MV, Situm M. Basic aspects of psychodermatology. Psychiatr Danub. 2008 Sep;20(3):415-8.

18. Biswajit A, Hazra J, Mitra A, Abedon B, Ghosal S. A standardized Withania somnifera extract significantly reduces stress-related parameters in chronically stressed humans: A double-blind, randomized, placebo-controlled study. JANA. 2008;11(1):50-6.

19. Chen TS, Liou SY, Chang YL. Antioxidant evaluation of three adaptogen extracts. Am J Chin Med. 2008;36(6):1209-17.

20. Padmavathi B, Rath PC, Rao AR, Singh RP. Roots of Withania somnifera inhibit forestomach and skin carcinogenesis in mice. Evid Based Complement Alternat Med. 2005 Mar;2(1):99-105.

21. Walsh N. Polypodium leucotomos for skin protection. Internal Medicine News. 2006 May 1.

22. Alcaraz MV, Pathak MA, Rius F, Kollias N, González S. An extract of Polypodium leucotomos appears to minimize certain photoaging changes in a hairless albino mouse animal model. A pilot study. Photodermatol Photoimmunol Photomed. 1999 Jun-Aug;15(3-4):120-6.

23. Philips N, Smith J, Keller T, Gonzalez S. Predominant effects of Polypodium leucotomos on membrane integrity, lipid peroxidation, and expression of elastin and matrixmetalloproteinase-1 in ultraviolet radiation exposed fibroblasts, and keratinocytes. J Dermatol Sci. 2003 Jun;32(1):1-9.

24. Available at: www.skincancer.org/understanding-uva-and-uvb.html. Accessed April 26, 2010.

25. Titus-Ernstoff L, Perry AE, Spencer SK, Gibson J, Ding J, Cole B, Ernstoff MS. Multiple primary melanoma: two-year results from a population-based study. Arch Dermatol. 2006 Apr;142(4):433-8.

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