~ June 2009 - Slim Down for Summer
Contents . . .
- More Weight Loss than Any Other Discovery in Supplement History
By William Faloon
I'll never forget an experience I had at a medical conference 14 years ago. A renowned scientist persistently asked me to sell him the hormone leptin.
When given to obese mice, leptin caused weight loss of 40% after 33 days.
In human terms, that equates to a 250-pound person shrinking to 150 pounds in a short time. The problem was that leptin did not work in humans, if they were not leptin-deficient to begin with.
This obese scientist kept badgering me because he thought I knew how to get leptin. When I repeatedly said it would not work for him, he asked me why it would not work. Back in 1994, I did not know that answer.
In a breakthrough that may reverse today's epidemic of obesity, a natural compound has been discovered that circumvents the molecular factors involved in obesity -- including a phenomenon known as "leptin-resistance." This means that for the first time, humans can benefit from their own leptin because it can now enter cells and do what it did for obese mice -- induce massive weight loss.
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- The Nine Pillars of Successful Weight Loss
By William Faloon
The Life Extension Foundation has a 29-year track record of identifying novel methods to address the health concerns of aging humans. For example, Life Extension warned long ago that atherosclerosis was caused by more than a dozen independent correctable risk factors, with cholesterol and LDL being only two of them.
When it comes to weight loss, mainstream medicine has recommended "diet and exercise" for so long that this phrase has become more of a clich茅 than any kind of momentous scientific communication.
The fact is that aging people need to do a lot more than reduce calorie intake and increase physical activity if they are going to lose and keep off excess body fat.
In this article, we succinctly address the nine steps that most overweight aging people should follow if they are to achieve optimal removal of surplus body fat. This multi-step program is analogous to the "drug cocktails" that doctors now use to control HIV infections in a way that enables patients to live for decades instead of less than one year, as was the case when the disease first manifested.
The Nine Pillars of Successful Weight Loss are also analogous to what progressive oncologists are doing to cure cancer today by administering multiple therapies designed to neutralize the numerous survival mechanisms cancer cells use to escape eradication.
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- Hit the Weights, Lose the Weight
One of every two American adults is following a reduced calorie diet plan, but according to a recent review of dieting studies, almost all dieters regained all of the weight lost during their restricted calorie period. Meanwhile, a 2008 study of physical activity in the United States found that less than 5 percent of adults perform even 30 minutes of moderate activity on a regular basis, defined as five days a week.
Perhaps the reason more people don't pursue an exercise approach is because the weight loss, although more permanent, comes more slowly than that attained by dieting. However, two 20-minute strength training sessions per week could be a large part of the solution.
The reason for this is the reduction in muscle tissue and metabolic rate that accompanies the aging process. As we age, our muscle mass decreases by 4-6 pounds per decade and our metabolic rate decreases by 2-3 percent per decade. While this may seem a minor factor in weight gain, a 2-3 percent per decade metabolic rate reduction results in a 15-20 pound fat accumulation, other things being equal. That is approximately the amount of fat middle-age adults gain on a decade by decade basis.
The good news is that it is relatively simple to reverse this process of muscle loss and metabolic slowdown. Several studies have demonstrated that a brief strength training program can increase both muscle tissue and resting metabolism.
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- Featured Product: Integra-Lean Irvingia
Scientists have identified specific biological mechanisms that cause aging people to gain weight--no matter how little they eat. The problem was that there was no way to circumvent the underlying factors that cause excess body fat--until now! As you are about to learn, gaining control over your body's command signals is critical to maintaining a healthy weight.
Leptin is a hormone that tells our brain that we have consumed enough calories and can stop eating. Leptin also induces a process whereby fat stored in cells is broken down. As we age, our cells (including the appetite control center in our brains) become "leptin resistant." This means that leptin is unable to effectively regulate body weight.
Adult-onset weight gain is characterized by the enlargement of existing adipocytes (fat cells) that store too much fat. The size of fat cells is controlled by gene transcription factors. Fat cell size is closely related with adiponectin expression--with reduced adiponectin expression in larger fat cells. In addition, gene transcription factors help regulate adiponectin, and this crucial hormone is critical for supporting insulin sensitivity.
Weight Loss Supplements
An enzyme called glycerol-3-phosphatedehydrogenase is critical for synthesizing fatty acids in our bodies. Suppressing this enzyme helps reduce the amount of glucose (sugar) in our bloodstream from being converted into fatty acids.
Weight loss utilizing diet modification, supplements, hormones or drugs usually functions via a single mechanism. Adipocytes (fat cells), on the other hand, possess numerous means to ensure their survival. An extract from a West African plant called Irvingia has been shown to help maintain healthy body weight in four ways:
1. Weight Management: Reversing Leptin Resistance
Fat cells produce C-reactive protein, a pro-inflammatory compound that leads to "leptin resistance." Overweight people given Irvingia have lower levels of CRP, and therefore less CRP is able to block the activity of leptin. Leptin is important in weight management because it promotes the breakdown of fat in adipocytes and tells the brain to turn off chronic hunger messages.
2. Hormones: Increasing Adiponectin
Large fat cells secrete less adiponectin, and adiponectin is a crucial hormone that helps support insulin sensitivity as well as cardiovascular health. Overweight people given Irvingia show markedly increased adiponectin levels.
3. Body Fat: Inhibiting the Fat Converting Enzyme
An enzyme called glycerol-3-phosphate dehydrogenase facilitates the conversion of glucose into triglycerides that increase adipocyte size. Irvingia inhibits glycerol-3-phosphate dehydrogenase, thus reducing the amount of glucose (sugar) that is converted to fat in the body.
4. Diet: Reducing Carbohydrate Absorption
In order for carbohydrates to be fully absorbed, they must be broken down in the digestive tract by the amylase enzyme. Irvingia inhibits amylase, and thus reduces the amount of ingested starches that will be absorbed as sugar.
Several studies demonstrate the weight loss properties of Irvingia.1 In the largest placebo controlled human study, those taking Irvingia lost 28 pounds over a 10-week period compared to only up to 3 pounds in the placebo group.2 The study participants did not alter their diet.
Based on impressive human data, a dose of 150 mg of Integra-Lean™ Irvingia taken twice a day is all that was needed to achieve unprecedented clinical results.
This supplement should be taken in conjunction with a healthy diet and regular exercise program. Results may vary.
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