As we age, our once-vigorous immune system begins to decline. The result is immune senescence, which has been linked to problematic outcomes in aging.1
A vital immune system is composed of a healthy balance of naive T cells that attack new invaders and memory T cells that attack previously known invaders. However, after a naive T cell attacks a new threat, it becomes a memory T cell, which will only go after a threat that it remembers.2,3 The result is that the delicate immune balance tips and we have a surplus of memory T cells and a deficit of naive T cells. With this imbalance, our body is less able to defend itself against new invasions. This produces a less-vigilant immune system—or immune senescence.4
Life Extension® researchers have developed an innovative, dual-mechanism formula designed to combat immune senescence.
Immune Senescence Protection Formula™ is composed of two botanical compounds that support both adaptive (e.g. naive T cells) and innate (e.g. macrophages and neutrophils) immune response cells. Together, these nutrients work in a complementary fashion to rejuvenate both major arms of the aging immune system through unique mechanisms.
Cistanche Rejuvenates Aging Immune System
Scientists have discovered that the echinacoside compound found in Cistanche plant extract stimulates the development of naive T cells and leads to a lower amount of memory T cells, thereby creating a more balanced immune response. Cistanche also increases natural killer (NK) cell activity—resulting in a 15% life span increase in animal research.5
A 12-week human study of a dietary supplement containing standardized Cistanche resulted in impressive gains in immune factors after supplementation. Subjects had significant improvements, including an 11.7% increase in natural killer (NK) cell activity and a 20.2% improvement in the ratio of CD4 to CD8 cells. An increased CD4/CD8 ratio is indicative of healthy, youthful immune function.6
Reishi Mushroom Combats Immune Senescence
The numerous bioactive components of the Reishi mushroom exert powerful effects that may reverse many of the factors of immune senescence.7
Reishi extracts boost the function of innate immune cells, the immune system’s first line of defense.7-9
It has long been known that Reishi’s unique polysaccharides, triterpenes, and other constituents10 enhance the body’s hematopoietic stem cells, macrophages, and other crucial immune factors.11-13 Animal research shows Reishi supports multiple aspects of immune function and longevity.14
Potent, Dual-Extract Formulation
Now, both Cistanche and Reishi are available in one powerful, dual-extract formulation, specifically created for year-round support of the aging immune system.
Reishi mushroom (Ganoderma lucidum) extract (fruit body) [std. to 13.5% polysaccharides (132.3 mg) and 6% triterpenes (58.8 mg)]
Shell-broken Reishi mushroom (Ganoderma lucidum) (spore)
Cistanche tubulosa extract (stem and leaf) [std. to 22% echinacosides (46.2 mg)]
vegetable cellulose (capsule), rice flour, starch, L-leucine, silica.
Take two (2) capsules daily with food, or as recommended by a healthcare practitioner.
- Immun Ageing. 2010;7:7.
- Immun Ageing. 2012 Jul 25;9(1):15.
- Available at: http://www.nia.nih.gov/health/publication/biology-aging/ immune-system-can-your-immune-system-still-defend-you-you-age . Accessed September 25, 2014.
- Immunity. 2008 Dec 19;29(6):848-62.
- Evid-Based Compl Alt. 2014;2014: 601383.
- Anti-Aging Medicine. 2011;8(2):7-14.
- Am J Chin Med. 2011;39(1):15-27.
- Available at: http://www.merckmanuals.com/home/immune_disorders/ biology_of_the_immune_system/overview_of_the_immune_system.html . Accessed September 25, 2014.
- Immunol Lett. 2002;83(3):163-9.
- Am-Euras. J. Bot. 2008;1(3):107-11.
- Bioorg Med Chem. 2010 Dec 15;18(24):8583-91.
- Front Pharmacol. 2012;3:135.
- Int J Med Mushrooms. 2011;13(5):441-8.
- FASEB J. 2011;25:601.2.