Immune Success Relates to Two Factors
In early experiments, a 70% EGCG prep made by a company called Dr. Hoffmann’s was used. This prep is NOT decaffeinated. According to Tom Lahey of Lutimax Nutraceuticals, decaffeination removes theanine as well as caffeine from the tea compounds. Most people have used a decaffeinated form of EGCG made by Food Science called Green Tea-70. This prep does not stimulate the immune system.
Theanine is a natural amino acid found only in tea plants. Its breakdown product stimulates a population of gamma delta T cells that are now known to control virtually the entire immune system. The activation of these cells stimulates the release of massive amounts of anti-viral immune hormones such as TNF and gamma interferon. HIV infection causes a deficiency in this subpopulation of T cells while theanine activates these cells.
However, these gamma delta cells must be mature in order to be activated by theanine products. The maturation process is induced by alpha or beta interferon. The alpha/beta interferon response against the HIV virus is well known to be grossly deficient. This means the maturation of these critical gamma delta T cells will remain defective. It also means that theanine, under these conditions, isn’t going to do anything.
Second, 800 mgs of ibuprofen was used daily for three months PRIOR to going on the EGCG. Ibuprofen blocks the Cox-2 enzyme which produces the prostaglandin PGE2. PGE2 stimulates cyclic AMP accumulation. Cyclic AMP is extremely immunosuppressive. Cyclic AMP inhibits the synthesis of IL-2, TNF, the zeta chain of the T cell receptor, AND the synthesis of both alpha and beta interferon. It also stimulates HIV synthesis, among other things. Since both the viral proteins p24 and gp120 stimulate PGE2 production, I ibuprofen to inhibit Cox-2 activity was used.
In three months time, the subject had stopped the progression of his disease and blocked the HIV induced immunosuppression by the use of ibuprofen. As the PGE2 induced cyclic AMP accumulation subsided, the immune system gained strength. Alpha and beta interferon, in the absence of cyclic AMP, was no doubt synthesized again, thereby blocking HIV synthesis and inducing the maturation of that critical population of gamma delta T cells. The theanine present in his EGCG prep further activated the immune response against the virus.
Blocking cyclic AMP accumulation, either due to Cox-2 inhibition, or by the use of general beta1/beta2 anti-hypertensive drugs, is absolutely critical to block HIV induced immunosuppression. Reducing stress is also crucial. Psychological stress is well known to enhance HIV infections, and it does so by increasing the release of epinephrine and norepinephrine, cyclic AMP inducing hormones.
1 gram of ibuprofen a day, 200 mgs 5 times a day. If you have stomach problems, take the OTC drug Prilosec with the ibuprofen. Prilosec is a proton pump inhibitor and it will prevent ibuprofen induced stomach ulceration.
OR, take the generic prescription drug indomethacin. This is much more powerful than ibuprofen and is normally used to treat gout. Obviously, you need a doctor’s prescription. It is inexpensive when purchased at Costco.
If stress is an issue, an old general beta1/beta2 blocker called pindolol is recommended. This drug also blocks the synthesis of both epinephrine and norepinephrine. It is prescribed off label as a treatment for anxiety. It is an inexpensive drug.
600 mgs of theanine a day. Open 3x 200 mgs caps and brew a little theanine tea. Theanine is very water soluble and it tastes good. Make enough tea to last for the entire day. Take it to work in a glass bottle. Drink it constantly, a little at a time but not all at once. It will make you very sleepy. Use more if you want.
400 mgs of CoQ10 in a gel cap, 200 mgs twice a day. CoQ10 increases the number of CD4 T cells in the body and it blocks the CR3 complement receptor. Activation of the CR3 receptor causes immunological tolerance which is known to exist in HIV infections.
Melatonin 3-6 mgs at night. Melatonin is a known immune enhancer and it blocks excessive glucocorticoid (hydrocortisone) activity, which is also immunosuppressive.
Use glutamine and arginine as needed, but not in massive doses. Glutamate, a breakdown product of glutamine, is immunosuppressive. 6 grams of glutamine is fine. Eat nuts to get your arginine.
Anti-oxidants like alpha lipoic acid, n-acetylcysteine (NAC) and vitamin C are fine, but not in excessive doses. 400 mgs of ALA, 1 gram of NAC and 1 gram of vitamin C are fine.
If you experience chills, fever and fatigue, it means the protocol is working. The immune system is becoming reactivated against the virus and it is releasing a fever causing immune hormones.