Forskolin (10 mg) - Life Extension - 120 Vegetarian Capsules - Twin Pak

Forskolin (10 mg) - Life Extension - 120 Vegetarian Capsules - Twin Pak
Item# LEF-01544x2
Retail Price: $32.00
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Forskolin, 10 mg 60 vegetarian capsules, Item# 01544 - 2 Bottle Twin Pak

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From the African coleus plant, Forskolin (Forskolli) is recommended for weight loss, eye pressure that causes Glaucoma, and skin conditions such as Psoriasis.

Forskolin may be helpful to control the underlying cause of glaucoma. The often successful use of forskolin to reduce intraocular pressure may be due to its unique ability to stimulate adenylate cyclase activity and increase cyclic adenosine monophosphate (cAMP) which regulates and activates critical enzymes required for the cellular energy required to move fluid out of the eye.

Also helps to lower blood pressure, and is one of Dr. Oz's top "Best Belly-Blasting Supplements" because researchers have found that forskolin can help to promote the breakdown of stored fats in animal and human fat cells. It may also release fatty acids from adipose tissue, which results in increased thermogenesis, resulting in loss of body fat and, theoretically, increased lean body mass.

A Duke University study found that forskolin can significantly reduce urinary tract infections and could enhance the ability of antibiotics to destroy E. coli, the bacteria that cause most bladder infections. The herb is currently an ingredient in some body-building products, and is used to enhance lean body mass.

"This herb has been used in Asia for centuries for a wide variety of ailments," Dr Abraham said. "However, one of its constant uses has been for treating painful urination."

In several experiments using mice, the Duke team found that some bacteria retreat to cells lining the bladder where antibiotics cannot reach them. "After customary antibiotic treatment, the vast majority of the bacteria are either killed by the antibiotics or eliminated during urination," Dr Abraham explained. "However, there are small numbers of bacteria that survive antibiotic treatment because they sneak into the lining of the bladder, waiting for the opportunity, after antibiotic treatment, to come out and start multiplying again."

Although the lining of the bladder is resistant to penetration, pouchlike structures that enable the organ to stretch create niches in which E. Coli can reside. By enhancing specific cellular activity, forskolin causes these pouches to flush their E. Coli colonies into the urine, rendering the bacteria destructible by antibiotics.

Because the current research used injectable and intravenous forskolin, Dr Abraham is planning to test the compoundís efficacy when administered orally. "This type of treatment strategy may prove to be beneficial for patients with recurrent urinary tract infections," Dr Abraham predicted. "Ideally, use of this herb would expel the bacteria, where it would then be hit with antibiotics. With the reservoir of hiding bacteria cleared out, the infection should not recur."

(April 8, 2007 journal Nature Medicine, Soman Abraham)

In the November 2005 issue of the journal Cancer Cell, scientists from Ohio State University identified a new pathway of chronic myelogenous leukemia (CML) progression. Chronic myelogenous leukemia develops when two chromosomes erroneously exchange genetic material during cell division, creating a new gene that produces the cancer-causing enzyme Bcr-Abl. Bcr-Abl turns on cell growth signals, which, when unchecked by phosphatases, result in the abnormal production of white blood cells. The disease is currently treated with the so-called wonder-drug Gleevec which blocks Bcr-Abl activity, but a large number of patients develop resistance to the treatment.

Until now, it was unknown how the disease progressed through its well defined stages. Danilo Perrotti, who is an assistant professor in the department of molecular virology, immunology and medical genetics at Ohio State University and colleagues discovered that Bcr-Abl stimulates the protein SET which inhibits the tumor suppressor phosphatase PP2A. The team discovered that in chronic myelogenous leukemia, PP2A suppression only occurs in the final, acute stage of the disease.

Acting on previous research findings that showed that forskolin, extracted from the root of the ornamental plant coleus forskohlii, could restore PP2A function, the extract was tested on normal, Gleevec-sensitive and Gleevec-resistant human CML cells. The researchers found that forskolin restored normal PP2A function, while reducing the cancer cells' ability to grow by up to 90 percent. It also induced cancer cell death and differentiation while failing to effect normal cells. When forskolin was tested on mice, withdrawal of the compound resulted in the death of some of the animals while others showed signs of Bcr-Abl activity, but when forskolin was readministered, Bcr-Abl was blocked.

Dr Perotti commented, "We believe these are significant findings. We have uncovered a key process that underlies progression in CML and identified an agent that can block it. We also have shown that forskolin can reinstate normal cell functioning, even in Gleevec-resistant cells that do not respond to any treatment currently available."

This product is best taken on an empty stomach.

Caution: Do Not Take Forskolin If You Have Prostate Cancer. If You Suffer From Arrhythmia, Use With Cooperation Of Your Cardiologist.

Supplement Facts

Serving Size: 1 vegetarian capsule

Servings Per Container: 60

Amount per Serving

Coleus forskohlii extract (root) [standardized to 10% forskolin (10 mg)] 100 mg

Other ingredients: rice flour, vegetable cellulose (capsule), maltodextrin, vegetable stearate.

Dosage and Use: Take one capsule daily on an empty stomach, or as recommended by a healthcare practitioner.

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