Boost Endothelial Function For
Optimal heart health depends on many factors,
including proper endothelial function.1 Even with cholesterol/glucose levels in the healthy range, aging individuals need to maintain
youthful integrity of their endothelium—the thin layer of cells lining the interior of the entire
Based on published studies showing improvements
in endothelial function, health-conscious people have
been drinking pomegranate juice or taking a standardized
Going Beyond Pomegranate
The addition of CORDIART™ (extract from sweet orange peels)
to pomegranate provides another vascular benefit by activating
endothelial production of nitric oxide, which signals the smooth
muscles to relax, inducing vasodilation to support healthy circulation.
In clinical research, 500 mg of CORDIART™ alone produced an
18% improvement in flow mediated dilation, a direct marker
of endothelial function. CORDIART™ also inhibited the
pro-inflammatory factors C-reactive protein and serum
amyloid A that interrupt healthy nitric oxide production.2
For those seeking the convenience of three nutrients clinically
shown to help with blood flow and age-related changes in
endothelial function,2-6 the newly formulated Endothelial
Defense™ provides GliSODin®, Full-Spectrum Pomegranate Complete
The orally active form of superoxide dismutase (SOD)—called
GliSODin®—has been clinically demonstrated to support healthy
arterial function and structure, while boosting levels of the body’s
protective enzymes—SOD and catalase.4-6 The new Endothelial
Defense contains a potent dose of GliSODin® along with 500 mg of CORDIART™.
The new Endothelial Defense™ also provides standardized
pomegranate juice extract and a proprietary pomegranate flower
and seed oil blend. These extracts from different parts of the
pomegranate plant provide potent polyphenols clinically shown to
support healthy blood flow, youthful lipid and glucose metabolism,
and healthy inflammatory factors.2,3,7-9
Endothelial Defense™ with Pomegranate Complete
and CORDIART™ addresses many factors that promote youthful
endothelial function in a dose of two softgel capsules daily.
Superoxide dismutase/gliadin complex (GliSODin®) [SOD (superoxide dismutase) enzyme activity = 500 IU]
CORDIART™ flavonoid glycoside [from immature sweet orange (peel)] [std. to 90% rutinoside]
POMELLA® pomegranate extract (fruit) [std. to 30% punicalagins]
Proprietary pomegranate blend (flower extract and seed oil) [std. to 22% punicic acid]
Pomegranate 5:1 extract (fruit)
extra virgin olive oil, gelatin, maltodextrin, glycerin, purified water, sunflower lecithin, carob color, beeswax.
POMELLA® Extract is covered under U.S. Patent 7,638,640 and POMELLA® is a registered trademark of Verdure Sciences, Inc.
CORDIART™ is a trademark of BioActor B.V.
Take one (2) softgels daily with food, or as recommended by a healthcare practitioner.
Do not take this product if you are allergic to wheat or gluten.
- Annu Rev Physiol. 2006;68:51-66.
- Bioactor B.V.;2013.
- Altern Med Rev. 2008 Jun;13(2):128.
- Eur Ann Allergy Clin Immunol. 2007 Feb;39(2):45-50.
- Phytother Res. 2004 Dec;18(12):957-62.
- Free Radic Res. 2004 Sep;38(9):927-32.
- Adv Biomed Res. 2014; 3:100.
- J Nutr Sci. 2012; 1:e9.
- Biofactors. 2015 Jan-Feb;41(1):44-51.