~ D-Alpha-Tocopherol Protects Renal Function in Rats with Diabetes

NewsRx.com, 09-30-05

D-alpha-tocopherol protects renal function in rats with diabetes.

According to recent research from Brazil, "The objective of the present study was to determine if treatment of diabetic rats with D-alpha-tocopherol could prevent the changes in glomerular and tubular function commonly observed in this disease. Sixty male Wistar rats divided into four groups were studied: control (C), control treated with D-alpha-tocopherol (C + T), diabetic (D), and diabetic treated with D-alpha-tocopherol (D + T). Treatment with D-alpha-tocopherol (40 mg/kg every other day, ip) was started three days after diabetes induction with streptozotocin (60 mg/kg, ip)."

"Renal function studies and microperfusion measurements were performed 30 days after diabetes induction and the kidneys were removed for morphometric analyses," said G. Nascimento Gomes and colleagues at the Universidade Federal de Sao Paulo. "Data are reported as mean±SEM. Glomerular filtration rate increased in D rats but decreased in D + T rats (C: 6.43±0.21; D: 7.74±0.45; D + T: 3.86±0.18 mL/min/kg)."

"Alterations of tubular acidification observed in bicarbonate absorption flux (JHCO3) and in acidification half-time (t/2) in group D were reversed in group D + T (JHCO3, C: 2.30±0.10; D: 3.28±0.22; D + T: 1.87±0.08 nmol/cm2/s; t/2, C: 4.75±0.20; D: 3.52±0.15; D + T: 5.92±0.19 s)," reported the researchers. "Glomerular area was significantly increased in D, while D + T rats exhibited values similar to C, suggesting that the vitamin prevented the hypertrophic effect of hyperglycemia (C: 8334.21±112.05; D: 10,217.55±100.66; D + T: 8478.21±119.81 micometer2)."

"These results suggest that D-alpha-tocopherol is able to protect rats, at least in part, from the harmful effects of diabetes on renal function," concluded the investigators.

Nascimento Gomes and coauthors published their study in the Brazilian Journal of Medical and Biological Research (Effect of D-alpha-tocopherol on tubular nephron acidification by rats with induced diabetes mellitus. Braz J Med Biol Res, 2005;38(7):1043-1051).

For additional information, contact G. Nascimento Gomes, Departamento de Fisiologia, Escola Paulista de Medicina, Universidade Federal de Sao Paulo (UNIFESP), Rua Botucatu 862, 5o Andar, BR-04023900 Sao Paulo, Brazil. E-mail: guiomar@ecb.epm.br.

Publisher contact information for the Brazilian Journal of Medical and Biological Research is: Association Bras Divulg Cientifica, Faculdade Medicina, Sala 21, 14049 Ribeirao Preto, Sao Paulo, Brazil.

Keywords: Sao Paulo, Brazil, Diabetic Nephropathy, Diabetes Complications, Renal Disease, Kidney Disease, Diet and Nutrition, Alpha-Tocopherol, Endocrinology. This article was prepared by Biotech Week editors from staff and other reports. Copyright 2005, Biotech Week via NewsRx.com.

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