~ Dietary Supplements Attacked by the Media - References, continued

80. Glucosamine long-term treatment and the progression of knee osteoarthritis: systematic review of randomized controlled trials.Ann Pharmacother. 2005 Jun;39(6):1080-7.

81. Blakeley JA & Iberia VEO. Glucosamine & Osteoarthritis. Am J Nurs. 2004 Feb;104(2):54-9; quiz 68-9.

82. Richy F, Bruyere O, Ethgen O, Cucherat M, Henrotin Y, Reginster JY. Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis. A comprehensive meta-analysis. Arch Intern Med . 2003 Jul 14;163(13):1514-22.

83. Miller DC , Richardson J, Roberts RW. Does glucosamine relieve arthritis joint pain? J Fam Pract. 2003 52:645-7.

84. Bruyere O, Honore A, Ethgen O, et al. Correlation between radiographic severity of knee osteoarthritis and future disease progression. Results from a 3 year prospective, placebo-controlled study evaluating the effect of glucosamine sulfate. Osteoarthritis & Cartilage. 2003 Jan;11(1):1-5.

85. Miller G, Rejeski W, Williamson J, et al. The Arthritis, Diet and Activity Promotion Trial (ADAPT): design, rationale, and baseline results. Control Clin Trials. 2003 Aug;24(4):462-80.

86. Braham R, Dawson B, Goodman C. The effect of glucosamine supplementation on people experiencing regular knee pain. Br J Sports Med . 2003 Feb;37(1):45-9.

87. Pavelka K, Gatterova J, Olejarova M, Machacek S, Giacovelli G, Rovati L. Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study. Arch Intern Med. 2002 162:2113-23.

88. Reginster J, Deroisy R, Rovati L, et al. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial. Lancet. 2001 357:251-6.

89. Chard J, Dieppe P. Glucosamine for osteoarthritis: magic, hype, or confusion? BMJ. 2001 June 16;322(7300):14391440.

90. Nahin RL, Straus SE. Research into complementary and alternative medicine: problems and potential. BJM. 2001 Jan 20;322(7279):161-4.

91. Mazieres B, Combe B, Phan Van A, Tondut J, Grynfeltt M. Chondroitin sulfate in osteoarthritis of the knee: a prospective, double-blind, placebo controlled multicenter clinical study. J Rheumatol. 2001 Jan;28(1):173-81.

92. Debi R, Robinson D, Agar G, Halperin N. GAG for osteoarthritis of the knee - a prospective study. Harefuah. 2000 Mar 15;138(6):451-3, 518.

93. McAlindon TE, La valley MP, Gulin JP, Felson DT. Glucosamine and chondroitin for treatment of osteoarthritis. JAMA. 2000 Mar 15;283(11):1469-75.

94. Leeb BF, Schweitzer H, Montag K, Smolen JS. A Metaanalysis of Chondroitin Sulfate in the Treatment of OA. J Rheumatol. 2000 Jan;27(1):205-11.

95. Leffler CT. Philippi AF, Leffler SG, Mosure JC, Kim PD. Glucosamine, chondroitin and manganese ascorbate for degenerative joint disease of the knee or low back : a randomized, double-blind, placebo-controlled pilot study. Mil Med. 1999 Feb;164(2):85-91.

96. Conn DL, Arnold WJ, Hollister JR. Alternative Treatments and Rheumatic Disease. Bull Rheum Dis. 1999 48(7):1-3.

97. da Camara CC, Dowless GV. Glucosamine Sulfate for Osteoarthritis. Ann Pharmacother. 1998 May;32(5):580-7.

98. Qiu GX, Gao SN, Giacovelli G, Rovati L, Setnikar I. Efficacy and safety of glucosamine sulfate versus ibuprofen in patients with knee osteoarthritis. Arzneimit-telforschung. 1998 May;48(5):469-74.

99. McAlindon T, Felson D. Nutrition: risk factors for osteoarthritis. Ann Rheum Dis. 1997 56:397-402.

100. Muller-Fasbender, H, et al.; Glucosamine sulfate compared to ibuprofen in osteoarthritis of the knee. Osteoarthritis Cartilage. 1997 Jul;56(7):397-400.

101. Morreale P, Manopulo R, Galati M, Boccanera L, Saponati G, Bocchi L. Comparison of the antiinflammatory efficacy of chondroitin sulfate and diclofenac sodium in patients with knee osteoarthritis. J Rheumatol. 1996 Aug 23;(8):1385-91.

102. Bucsi L , Poor G. Efficacy and tolerability of oral chondroitin sulfate as a symptomatic slow-acting drug for osteoarthritis (SYSADOA) in the treatment of knee osteoarthritis.Osteoarthritis Cartilage. 1998 May;6 Suppl A:31-6.

103. Miller DC, Richardson J. Does glucosamine relieve arthritis joint pain? J Fam Pract. 2003 52:645-7.

104. Deal C, Moskowitz R. Nutraceuticals as therapeutic agents in osteoarthritis. The role of glucosamine, chondroitin sulfate, and collagen hydrolysate. Rheum Dis Clin North Am. 1999 25:379-95.

105. Uebelhart D, Thonar E, Delmas PD, et al. Chondroitin 4 and 6 sulfate: A symptomatic slow-acting drug for osteoarthritis does also have structural modifying properties. Osteoarthritis & Cartilage. 1997 5:70.

106. Verbruggen G, Goemaere S, Veys EM. Chondroitin sulfate S/DMOAD (Structure/Disease Modifying Osteoarthritis (OA) Drug) in the treatment of OA of the finger joints. Osteoarthritis & Cartilage. 1997 5:70.

107. D'Ambrosia E, Casa B, Bompani R, Scali G, Scali M. Glucosamine sulfate: a controlled clinical investigation in arthrosis. Pharmatherapeutica. 1981;2(8):504-8.

108. Crolle G, D'Este.. Glucosamine sulfate for the management of arthrosis. Curr Med Res Opin. 1980 7:104-9.

109. Vajaradul Y . Double-blind clinical evaluation of intra-articular glucosamine in outpatients with gonarthrosis. Clin Ther . 1981;3(5):336-43.

110. Pujalte JM , Llavore EP, Ylescupidez FR. Double-blind clinical evaluation of oral glucosamine sulphate in the basic treatment of osteoarthrosis. Curr Med Res Opin . 1980;7(2):110-14.

111. Singh G, Miller JD, Lee FH, Pettitt D, Russell MW. Prevalence of cardiovascular disease risk factors among U.S. adults with self-reported osteoarthritis: data from the Third National Health and Nutrition Examination Survey. Am J Manag Care. 2002 Oct;8(15 Suppl):S383-91.

112. Available at: http://www.lef.org/magazine/mag99/oct99-cover.html Accessed March 2006

113. Available at: http://www.lef.org/magazine/mag2001/jan2001_report_cox2_1.html Accessed March 2006

114. Hendler SS, Rorvik D. PDR for Nutritional Supplements, 1st Ed. Montvale, NJ: Medical Economics Co; 2001:149.

115. Mayatepek E, Paul K, Leichsenring M, et al. Influence of dietary (n-3)-polyunsaturated fatty acids on leukotriene B4 and prostaglandin E2 synthesis and course of experimental tuberculosis in guinea pigs. Infection. 1994 Mar;22(2):106-12.

116. Ferretti A, Flanagan VP, Reeves VB. Occurrence of prostaglandin E3 in human urine as a result of marine oil ingestion: gas chromatographic-mass spectrometric evidence. Biochim Biophys Acta. 1988 Apr 15;959(3):262-8.

117. Available at: http://www.lef.org/magazine/mag2004/jun2004_ch_01.htm Accessed March 2006

118. Rizzo R, Grandolfo M, Godeas C, Jones KW, Vittur F. Calcium, sulfur, and zinc distribution in normal and arthritic articular equine cartilage: a synchrotron radiation-induced X-ray emission (SRIXE) study. J Exp Zool. 1995 Sep 1;273(1):82-6.

119. Murav'ev I, Venikova MS, Pleskovskaia GN, Riazantseva TA, Sigidin I. Effect of dimethyl sulfoxide and dimethyl sulfone on a destructive process in the joints of mice with spontaneous arthritis. Patol Fiziol Eksp Ter. 1991 Mar-Apr;(2):37-9.

120. Lawrence RM. Methylsulfonylmethane (MSM): a double-blind study of its use in degenerative arthritis. Int J Anti-Aging Med. 1998 1:50.

121. Buck AC. Is there a scientific basis for the therapeutic effects of serenoa repens in benign prostatic hyperplasia? Mechanisms of action. J Urol . 2004 Nov;172(5 Pt 1):1792-9.

122. Gong EM, Gerber GS. Saw palmetto and benign prostatic hyperplasia. Am J Chin Med. 2004 32(3):331-8.

123. Gerber GS, Fitzpatrick JM. The role of a lipido-sterolic extract of Serenoa repens in the management of lower urinary tract symptoms associated with benign prostatic hyperplasia. BJU Int . 2004 Aug;94(3):338-44.

124. Boyle P, Robertson C, Lowe F, Roehrborn C. Updated meta-analysis of clinical trials of Serenoa repens extract in the treatment of symptomatic benign prostatic hyperplasia. BJU Int. 2004 Apr;93(6):751-6.

125. Wilt TJ, Ishani A, Rutks I, MacDonald R. Phytotherapy for benign prostatic hyperplasia . Public Health Nutr . 2000 Dec;3(4A):459-72.

126. Gerber G. Saw Palmetto For The Treatment Of Men With Lower Urinary Tract Symptoms. J Urol 2000 May;163(5):1408-12 ( Review)

127. Al-Shukri SH, Deschaseaux P, Kuzmin IV, Amdiy RR. Early urodynamic effects of the lipido-sterolic extract of Serenoa repens (Permixon(R)) in patients with lower urinary tract symptoms due to benign prostatic hyperplasia.Prostate Cancer Prostatic Dis. 2000 Nov;3(3):195-199.

128. Goepel M, Hecker U, Krege S, Rubben H, Michel MC. Saw palmetto extracts potently and noncompetitively inhibit human alpha1-adrenoceptors in vitro. Prostate . 1999 Feb 15;38(3):208-15.

129. Debruyne F, Koch G, Boyle P, et al. [Comparison of a phytotherapeutic agent (Permixon) with an alpha-blocker (Tamsulosin) in the treatment of benign prostatic hyperplasia: a 1-year randomized international study]. Prog Urol. 2002 Jun;12(3):384-92; discussion 394-4. French.

130. Marks LS, Partin AW, Epstein JI, et al. Effects of a saw palmetto herbal blend in men with symptomatic benign prostatic hyperplasia. J Urol. 2000 May;163(5):1451-6.

131. Carraro JC, Raynaud JP, Koch G, et al. Comparison of phytotherapy (Permixon) with finasteride in the treatment of benign prostate hyperplasia: a randomized international study of 1,098 patients. Prostate. 1996 Oct;29(4):231-40.

132. Vela Navarrete R, Garcia Cardoso JV, Barat A, Manzarbeitia F, Lopez Farre A. BPH and inflammation: pharmacological effects of Permixon on histological and molecular inflammatory markers. Results of a double blind pilot clinical assay. Eur Urol. 2003 Nov;44(5):549-55.

133. Veltri RW, Marks LS, Miller MC, Et Al. Saw palmetto alters nuclear measurements reflecting DNA content in men with symptomatic BPH: evidence for a possible molecular mechanism. Urology. 2002 Oct;60(4):617-22.

134. Giannakopoulos X, Baltogiannis D, Giannakis D, Et al. The lipidosterolic extract of Serenoa repens in the treatment of benign prostatic hyperplasia: a comparison of two dosage regimens. Adv Ther. 2002 Nov-Dec;19(6):285-96.

135. Oki T , Suzuki M, Nishioka Y, Yasuda A, Umegaki K, Yamada S. Effects of saw palmetto extract on micturition reflex of rats and its autonomic receptor binding activity. J Urol. 2005 Apr;173(4):1395-9.

136. Pytel' IuA , Lopatkin NA, Gorilovskii LM, Vinarov AZ, Sivkov AV, Medvedev AA. [The results of long-term permixon treatment in patients with symptoms of lower urinary tracts dysfunction due to benign prostatic hyperplasia]. Urologiia. 2004 Mar-Apr;(2):3-7.

137. Aliaev IuG , Vinarov AZ, Lokshin KL, Spivak LG. [Five-year experience in treating patients with prostatic hyperplasia patients with permixone (Serenoa repens "Pierre Fabre Medicament)]. Urologiia. 2002 Jan-Feb;(1):23-5.

138. Stepanov VN , Siniakova LA, Sarrazin B, Raynaud JP. Efficacy and tolerability of the lipidosterolic extract of Serenoa repens (Permixon) in benign prostatic hyperplasia: a double-blind comparison of two dosage regimens. Adv Ther. 1999 Sep-Oct;16(5):231-41.

139. Wilt TJ , Ishani A, Stark G, MacDonald R, Lau J, Mulrow C. Saw palmetto extracts for treatment of benign prostatic hyperplasia: a systematic review. JAMA. 1998 Nov 11;280(18):1604-9.

140. Plosker GL , Brogden RN. Serenoa repens (Permixon). A review of its pharmacology and therapeutic efficacy in benign prostatic hyperplasia.Drugs Aging. 1996 Nov;9(5):379-95.

141. Gerber G, Kuznetsov D, Johnson B, Burstein, J. Randomized, Double-Blind, Placebo-Controlled Trial Of Saw Palmetto In Men With Lower Urinary Tract Symptoms. Urology. 2001 58:960965.

142. Popa G, Hagele-Kaddour H, Walther C. [Efficacy of a combined Sabal-urtica preparation in the symptomatic treatment of benign prostatic hyperplasia. Results of a placebo-controlled double-blind study]. MMW Fortschr Med. 2005 Oct 6;147 Suppl 3:103-8.

143. Sokeland J. Combined sabal and urtica extract compared with finasteride in men with benign prostatic hyperplasia: analysis of prostate volume and therapeutic outcome. BJU Int. 2000 Sep;86(4):439-42.

144. Odenthal KP. Phytotherapy of benign prostatic hyperplasia (BPH) with Cucurbita, Hypoxis, Pygeum, Urtica and Sabal serrulata (Serenoa repens). Phytotherapy Research. 1996 10/SUPPL. 1(S141-S143)

145. Lopatkin N, Sivkov A, Walther C. Long-term efficacy and safety of a combination of sabal and urtica extract for lower urinary tract symptoms--a placebo-controlled, double-blind, multicenter trial. World J Urol. 2005 Jun;23(2):139-46.

146. Preventing diseases of the prostate in the elderly using hormones and nutriceuticals. Aging Male. 2004 Jun;7(2):155-69.

147. Ellem SJ , Risbridger GP. Aromatase and prostate cancer. Minerva Endocrinol .2006 Mar;31(1):1-12.

148. Harkonen PL , Makela SI. Role of estrogens in development of prostate cancer. J Steroid Biochem Mol Biol. 2004 Nov;92(4):297-305.

149. Risbridger GP , Bianco JJ, Ellem SJ, McPherson SJ. Oestrogens and prostate cancer. Endocr Relat Cancer . 2003 Jun;10(2):187-91.

150. Krzeski T , Kazon M, Borkowski A, Witeska A, Kuczera J. Combined extracts of Urtica dioica and Pygeum africanum in the treatment of benign prostatic hyperplasia: double-blind comparison of two doses. Clin Ther . 1993 Nov-Dec;15(6):1011-20.

151. Vahlensieck W Jr , Fabricius PG, Hell U . [Drug therapy of benign prostatic hyperplasia]. Fortschr Med. 1996 Nov 10;114(31):407-11.

152. Katz AE . Flavonoid and botanical approaches to prostate health. J Altern Complement Med. 2002 Dec;8(6):813-21.

153. Wilt TJ, Ishani A, Rutks I, MacDonald R. Phytotherapy for benign prostatic hyperplasia . Public Health Nutr . 2000 Dec;3(4A):459-72.

154. Sokeland J, Albrecht J. [Combination of Sabal and Urtica extract vs. finasteride in benign prostatic hyperplasia (Aiken stages I to II). Comparison of therapeutic effectiveness in a one year double-blind study]. Urologe A. 1997 Jul;36(4):327-33.

155. Schneider HJ, Honold E, Masuhr T. [Treatment of benign prostatic hyperplasia. Results of a treatment study with the phytogenic combination of Sabal extract WS 1473 and Urtica extract WS 1031 in urologic specialty practices]. Fortschr Med. 1995 Jan 30;113(3):37-40.

156. Vahlensieck W Jr , Fabricius PG, Hell U . [Drug therapy of benign prostatic hyperplasia]. Fortschr Med. 1996 Nov 10;114(31):407-11.

157. Preuss HG, Marcusen C, Regan J, Klimberg IW, Welebir TA, Jones WA. Randomized trial of a combination of natural products (cernitin, saw palmetto, B-sitosterol, vitamin E) on symptoms of benign prostatic hyperplasia (BPH). Int Urol Nephrol. 2001 33(2):217-25.

158. Breza J, Dzurny O, Borowka A, et al. Efficacy and acceptability of tadenan (Pygeum africanum extract) in the treatment of benign prostatic hyperplasia ( BPH): a multicentre trial in central Europe. Curr Med Res Opin. 1998 14(3):127-39.

159. Wilt TJ, Ishani A, Mac Donald R, Rutks I, Stark G. Pygeum africanum for benign prostatic hyperplasia (Cochrane Review). The Cochrane Library. Vol Issue 3. Chichester, UK: John Wiley & Sons, Ltd.; 2004.

160. Santa Maria M, Paciucci B, Reventos P, Morote R, Thomson O. Antimitogenic effect of Pygeum africanum extracts on human prostatic cancer cell lines and explants from benign prostatic hyperplasia. Arch Esp Urol. 2003 May;56(4):369-78.

161. Konrad L , Muller HH, Lenz C, Laubinger H, Aumuller G, Lichius JJ. Antiproliferative effect on human prostate cancer cells by a stinging nettle root (Urtica dioica) extract. Planta Med. 2000 Feb;66(1):44-7.

162. Riehemann K, Behnke B, Schulze-Osthoff K. Plant extracts from stinging nettle (Urtica dioica), an antirheumatic remedy, inhibit the proinflammatory transcription factor NF-kappaB. FEBS Lett. 1999 Jan 8;442(1):89-94.

163. Lichius JJ , Muth C. The inhibiting effects of Urtica dioica root extracts on experimentally induced prostatic hyperplasia in the mouse. Planta Med. 1997 Aug;63(4):307-10.

164. Yablonsky F, Nicolas V, Riffaud JP, Bellamy F. Antiproliferative effect of Pygeum africanum extract on rat prostatic fibroblasts.J Urol 1997 Jun;157(6):2381-7.

165. Berges RR, Kassen A, Senge T. Treatment of symptomatic benign prostatic hyperplasia with beta-sitosterol: an 18-month follow-up. BJU Int. 2000 May;85(7):842-6. PMID 10792163

166. Berges RR, Windeler J, Trampisch HJ, Senge T. Randomised, placebo-controlled, double-blind clinical trial of beta-sitosterol in patients with benign prostatic hyperplasia. Beta-sitosterol Study Group. Lancet. 1995 Jun 17;345(8964):1529-32. PMID 7540705

167. Klippel KF, Hiltl DM, Schipp B. A multicentric, placebo-controlled, double-blind clinical trial of beta-sitosterol (phytosterol) for the treatment of benign prostatic hyperplasia. German BPH-Phyto Study group. Br J Urol. 1997 Sep;80(3):427-32. PMID 9313662

168. Wilt TJ, MacDonald R, Ishani A. beta-sitosterol for the treatment of benign prostatic hyperplasia: a systematic review. BJU Int. 1999 Jun;83(9):976-83. PMID 10368239

169. Wilt T, Ishani A, MacDonald R, Stark G, Mulrow C, Lau J. Beta-sitosterols for benign prostatic hyperplasia. Cochrane Database Syst Rev. 2000;(2):CD001043. PMID 10796740

170. von Holtz RL, Fink CS, Awad AB. Beta-Sitosterol activates the sphingomyelin cycle and induces apoptosis in LNCaP human prostate cancer cells. Nutr Cancer. 1998;32(1):8-12. PMID 9824850

171. Awad AB, Fink CS, Williams H, Kim U. In vitro and in vivo (SCID mice) effects of phytosterols on the growth and dissemination of human prostate cancer PC-3 cells. Eur J Cancer Prev. 2001 Dec;10(6):507-13. PMID 11916349

172. Awad AB, Gan Y, Fink CS. Effect of beta-sitosterol, a plant sterol, on growth, protein phosphatase 2A, and phospholipase D in LNCaP cells. Nutr Cancer. 2000;36(1):74-8. PMID 10798219

173. Nakase S, Takenaka K, Hamanaka T, Kimura M. Effects of Cernilton pollen-extract on urethral smooth muscle and diaphragmatic neuromuscular specimen. Folio Pharmacol Jpn. 1988;91:385-92.

174. Ito R, Ishii M, S. Y, et al. Antiprostatic hypertrophic action of Cernilton pollen-extract. Pharmacometrics. 1986;31:1-11.

175. Kimura M, Kimura I, Nakase K, Sonobe T, Mori N. Micturition activity of pollen extract: contractile effects on bladder and inhibitory effects on urethral smooth muscle of mouse and pig. Planta Med. 1986 Apr;(2):148-51.

176. Loschen G, Ebeling L. Inhibition of arachidonic acid cascade by extract of rye pollen. Arzneimittelforschung. 1991 Feb;41(2):162-7.

177. Tunn S, Krieg M. Hormone metabolism in the human prostate. In: Vahlensieck W, Rutishauser G, eds. Benign Prostate Diseases. New York, NY: Thieme Medical Publishers, Inc.; 1992:17-21.

178. Dutkiewicz S. Usefulness of Cernilton in the treatment of benign prostatic hyperplasia. Int Urol Nephrol. 1996;28(1):49-53.

179. Yasumoto R, Kawanishi H, Tsujino T, et al. Clinical evaluation of long-term treatment using cernitin pollen extract in patients with benign prostatic hyperplasia. Clin Ther. 1995 Jan-Feb;17(1):82-7.

180. Buck AC, Cox R, Rees RW, Ebeling L, John A. Treatment of outflow tract obstruction due to benign prostatic hyperplasia with the pollen extract, cernilton. A double-blind, placebo-controlled study. Br J Urol. 1990 Oct;66(4):398-404.

181. Habib FK, Ross M, Buck AC, Ebeling L, Lewenstein A. In vitro evaluation of the pollen extract, cernitin T-60, in the regulation of prostate cell growth. Br J Urol. 1990 Oct;66(4):393-7.


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