~ Curcumin May Be Effective Treatment for
Inflammatory Bowel Disease (IBD)

Ulcerative colitis and Crohn's disease are inflammatory bowel diseases characterized by abdominal pain, digestive difficulty, diarrhea or constipation and recurrent bowel ulceration. The July 2003 issue of the American Physiological Society journal, Gastrointestinal and Liver Physiology published the findings of Canadian researchers that curcumin, a derivative of the common spice turmeric, may be a well-tolerated and effective therapy for these diseases.

The researchers induced inflammatory bowel disease in mice, some of whom had been pretreated with curcumin for five days. Following induction of IBD, the mice were weighed daily for five days, after which their colons were examined. The investigators found that mice that had been treated with curcumin had less weight loss and better intestinal cell function than the untreated mice. Examination of colon wall cells showed greater mucosal ulceration, thickening of the walls and infiltration of inflammatory cells in untreated compared to treated mice.

Previous research has pointed to activation of the transcription factor NF-B in Crohn's disease, which is involved in the production of inflammatory cytokines and chemokines. The reduction in NF-B DNA binding found in the curcumin treated animals in the current study proved that curcumin inhibits NF- B activation in the colon.

The study utilized a dietary concentration of 0.25 percent curcumin to obtain benefits, yet curcumin's safety has been demonstrated at levels as high as 10 percent. Although the researchers are uncertain in regard to the mechanism of action of curcumin in IBD, they suggest that a combination of its free radical scavenging ability and its effect on NF-B as well as other activities may be responsible for its benefits. They propose that curcumin may have implications for managing inflammatory bowel disease in humans, which currently afflicts approximately two million Americans.

Free Shipping in the Continental U.S. on Orders over $50
The statements made here have not been evaluated by the FDA. The foregoing statements are based upon sound and reliable studies, and are meant for informational purposes. Consult with your medical practitioner to determine the underlying cause of your symptoms. Please always check your purchase for possible allergins and correct dosage on the bottle before use.

While we work to ensure that product information is correct, on occasion manufacturers may alter their ingredient lists. Actual product packaging and materials may contain more and/or different information than that shown on our Web site. We recommend that you do not solely rely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. For additional information about a product, please contact the manufacturer. Content on this site is for reference purposes and is not intended to substitute for advice given by a physician, pharmacist, or other licensed health-care professional. You should not use this information as self-diagnosis or for treating a health problem or disease. Contact your health-care provider immediately if you suspect that you have a medical problem. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease or health condition. Life Ex Online assumes no liability for inaccuracies or misstatements about products.