~ Curcumin Fights Melanoma in Vitro and in Vivo

The September 2004 issue of the International Journal of Cancer (http://www3.interscience.wiley.com/cgi-bin/jhome/29331) published the findings of researchers in Reims, France, that curcumin has an antitumor effect in cell cultures of melanoma and in mice with the disease. Curcumin is derived from turmeric, a spice commonly used in Indian and other cuisines that has been found to be protective against some cancers as well as other diseases.

In the in vitro experiments, the research team administered curcumin to single layers of mouse melanoma cells and found a dose-dependent decrease in cell viability regardless of the amount of time that the cells were exposed. They also studied curcumin's effect on cells grown in three dimensional cultures that are more like solid tumors found in living organisms. Curcumin increased cell death in these cultures as well, although the cells were more resistant than the single layer cultures. Further investigation revealed that programmed cell death, known as apoptosis, was responsible for the antitumor effect observed in these experiments, which has been demonstrated in other studies.

To study curcumin's antitumoral effect in vitro, a group of mice with melanoma were pretreated with an immune therapy that contained proteins derived from the melanoma cells, while another group was treated with curcumin, and a third group received both treatments. While each treatment alone resulted in little benefit, the combination significantly inhibited tumor growth and improved immune response in the mice that received it. When survival was evaluated, the immune preparation and curcumin were found to similarly enhance median survival time (by 48.6 percent and 45.7 percent respectively), and the combined treatments further increased median survival time by 82.8 percent compared to untreated mice.

The authors conclude that the study "shows that curcumin may provide a valuable tool for the development of a therapeutic combination against melanoma."

Free Shipping in the Continental U.S. on Orders over $50
The statements made here have not been evaluated by the FDA. The foregoing statements are based upon sound and reliable studies, and are meant for informational purposes. Consult with your medical practitioner to determine the underlying cause of your symptoms. Please always check your purchase for possible allergins and correct dosage on the bottle before use.

While we work to ensure that product information is correct, on occasion manufacturers may alter their ingredient lists. Actual product packaging and materials may contain more and/or different information than that shown on our Web site. We recommend that you do not solely rely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. For additional information about a product, please contact the manufacturer. Content on this site is for reference purposes and is not intended to substitute for advice given by a physician, pharmacist, or other licensed health-care professional. You should not use this information as self-diagnosis or for treating a health problem or disease. Contact your health-care provider immediately if you suspect that you have a medical problem. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease or health condition. Life Ex Online assumes no liability for inaccuracies or misstatements about products.