~ Cranberries May Aid Clearance of Excessive Cholesterol in Circulation
Cranberries inhibit LDL oxidation and induce LDL receptor expression in hepatocytes.
According to scientists in the United States, "Cardiovascular disease (CVD) is the leading cause of death in most industrialized countries. Cranberries were evaluated for their potential roles in dietary prevention of CVD."
Y.F. Chu and R.H. Liu of Cornell University reported, "Cranberry extracts were found to have potent antioxidant capacity preventing in vitro LDL oxidation with increasing delay and suppression of LDL oxidation in a dose-dependent manner. The antioxidant activity of 100 g cranberries against LDL oxidation was equivalent to 1000 mg vitamin C or 3700 mg vitamin E."
"Cranberry extracts also significantly induced expression of hepatic LDL receptors and increased intracellular uptake of cholesterol in HepG2 cells in vitro in a dose-dependent manner. This suggests that cranberries could enhance clearance of excessive plasma cholesterol in circulation," they noted.
The authors concluded, "We propose that additive or synergistic effects of phytochemicals in cranberries are responsible for the inhibition of LDL oxidation, the induced expression of LDL receptors, and the increased uptake of cholesterol in hepatocytes."
Chu and Liu published their study in Life Sciences (Cranberries inhibit LDL oxidation and induce LDL receptor expression in hepatocytes. Life Sci, 2005;77(15):1892-901).
For additional information, contact R.H. Liu, Department of Food Science, Stocking Hall, Cornell University, Ithaca, NY 14853-7201, USA. RL23@cornell.edu
The publisher of the journal Life Sciences can be contacted at: Pergamon-Elsevier Science Ltd., the Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, England.
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