~ Cardiovascular Health Benefit of Garlic Compounds May Be Due to Suppression of LDL Oxidation

NewsRx.com, 04-21-06

Suppression of LDL oxidation by garlic compounds is a possible mechanism of cardiovascular health benefit.

According to a recent report in the Journal of Nutrition, "Hypercholesterolemia is a major risk factor for atherosclerosis, and lowering cholesterol can significantly reduce the risk for cardiovascular diseases. Oxidation of LDL has recently been recognized as playing an important role in the initiation and progression of atherosclerosis."

Loma Linda University researcher B.H.S. Lau wrote, "Oxidized LDL, but not native LDL, promotes vascular dysfunction by exerting direct cytotoxicity to endothelial cells, by increasing chemotactic properties of monocytes, by transforming macrophages to foam cells, and by enhancing the proliferation of endothelial cells, monocytes, and muscle cells. All these events are recognized as contributors to cardiovascular diseases."

"This paper presents experimental evidence showing that several garlic compounds can suppress LDL oxidation in vitro. Short-term supplementation of garlic in human subjects has demonstrated an increased resistance of LDL to oxidation," the author noted. "These data suggest that suppressed LDL oxidation may be one of the mechanisms that accounts for the beneficial effects of garlic in cardiovascular health."

Lau published the report in the Journal of Nutrition (Suppression of LDL oxidation by garlic compounds is a possible mechanism of cardiovascular health benefit. J Nutr, 2006;136(3 Suppl. S):765S-768S).

For additional information, contact B.H.S. Lau, Loma Linda University School of Medicine, Dept. of Microbiology & Molecular Genetics, Loma Linda, CA 92350, USA.

The publisher's contact information for the Journal of Nutrition is: American Society of Nutritional Science, 9650 Rockville Pike, RM L-2407A, Bethesda, MD 20814, USA.

Free Shipping in the Continental U.S. on Orders over $50
The statements made here have not been evaluated by the FDA. The foregoing statements are based upon sound and reliable studies, and are meant for informational purposes. Consult with your medical practitioner to determine the underlying cause of your symptoms. Please always check your purchase for possible allergins and correct dosage on the bottle before use.

While we work to ensure that product information is correct, on occasion manufacturers may alter their ingredient lists. Actual product packaging and materials may contain more and/or different information than that shown on our Web site. We recommend that you do not solely rely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. For additional information about a product, please contact the manufacturer. Content on this site is for reference purposes and is not intended to substitute for advice given by a physician, pharmacist, or other licensed health-care professional. You should not use this information as self-diagnosis or for treating a health problem or disease. Contact your health-care provider immediately if you suspect that you have a medical problem. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease or health condition. Life Ex Online assumes no liability for inaccuracies or misstatements about products.