~ Bioactive Food Stimulants Increase Energy Expenditure and Fat Oxidation

NewsRx.com, 07-29-05

Bioactive food stimulants increase energy expenditure and fat oxidation.

"Bioactive food ingredients influence energy balance by exerting weak thermogenic effects. We studied whether the thermogenic effect of a combination of capsaicin, green tea extract (catechins and caffeine), tyrosine, and calcium was maintained after 7-day treatment and whether local effects in the gastric mucosa were involved in the efficacy. The present study was designed as a three-way crossover, randomized, placebo-controlled, double-blinded intervention involving 19 overweight to obese men (BMI: 28.072.7 kg/m2) who were recruited by advertising locally. The subjects took the supplements for a period of 7 days," scientists in Denmark report.

"The supplements were administrated as a simple supplement with the bioactive ingredients, a similar entero-coated version, or placebo," said Anita Belza and Anna B. Jessen at the Royal Veterinary and Agricultural University. "In all, 24-hour energy expenditure (EE), substrate oxidations, spontaneous physical activity (SPA), and heart rate were measured in respiration chambers on the seventh day of each test period. After adjustment for changes in body weight and SPA, 24-hour EE was increased by 160 kJ/day (95% CI: 15-305) by the simple preparation as compared to placebo, whereas the enterocoated preparation had no such effect (53 kJ/day, -92 to 198); simple vs enterocoated versions (p=0.09)."

"The simple preparation produced a deficit in 24-hour energy balance of 193 kJ/day (49-338, p=0.03)," reported Belza and Jessen. "Fat and carbohydrate oxidation were equally increased by the supplements. A supplement containing bioactive food ingredients increased daily EE by (approx)200 kJ or 2%, without raising the heart rate or any observed adverse effects. The lack of effect of the enterocoated preparation suggests that a local action of capsaicin in the gastric mucosa is a prerequisite for exerting the thermogenic effect."

Belza and Jessen published their study in the European Journal of Clinical Nutrition (Bioactive food stimulants of sympathetic activity: effect on 24-h energy expenditure and fat oxidation. Eur J Clin Nutr, 2005;59(6):733-741).

For additional information, contact Anita Belza, Department of Human Nutrition, Center for Advanced Food Studies, Royal Veterinary and Agricultural University, Frederiksberg, Denmark. E-mail: anbe@kvl.dk.

The publisher's contact information for the European Journal of Clinical Nutrition is: Nature Publishing Group, Macmillan Building, 4 Crinan Street, London N1 9XW, England.

Keywords: Frederiksberg, Denmark, Diet and Nutrition, Caffeine, Calcium, Capsaicin, Complementary and Alternative Medicine, Energy Expenditure, Green Tea, Obesity Therapy, Weight Loss, Metabolism. This article was prepared by Biotech Week editors from staff and other reports. Copyright 2005, Biotech Week via NewsRx.com.

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