~ August 2005 - SOD Relieves Inflammatory Discomfort

Contents . . .
  • Super Oxide Dismutase (SOD) - Powerful Protection Against Oxidative Stress

    By John Colman

    Boosting your body's store of the enzyme SOD provides powerful protection against oxidative stress.

    While everyone needs oxygen to stay alive, the same oxygen that sustains life also contributes to the generation of dangerous free radicals. Thousands of published studies implicate free radicals in the development of degenerative disease and accelerated aging. Young people naturally produce the antioxidant enzymes superoxide dismutase (SOD), catalase, and glutathione peroxidase to help protect against free radicals produced during normal physiological processes.

    Levels of SOD and other critical antioxidant enzymes decline with age, contributing to the scourge of age-related disease and decline. Fortunately, recent advances in nutritional science now allow adults to replenish their stores of these powerful antioxidant enzymes. Emerging research suggests that two novel SOD products—SODzyme™ and GliSODin®—help boost antioxidant status, reduce pain, quench free radicals, quell inflammation, and promote longevity.

    Learn more . . .
  • Rethinking Women and Coronary Heart Disease

    By Dr. Sergey Dzugan

    Coronary heart disease (CHD) is the leading cause of death in the Western world. Although physicians and patients tend to think of CHD as a man's disease, it is the leading cause of death among women in the US. Because of this misconception, physicians may fail to look for this condition in women or fail to recognize its warning signs, which may differ among women and men.

    Numerous risk factors contribute to CHD risk, including non-modifiable factors such as age and family history, and modifiable risk factors such as cholesterol level, homocysteine level, and high blood pressure. Because the incidence of CHD in women increases markedly following menopause (when levels of ovarian hormones drop dramatically), researchers have speculated that female hormones may play a cardioprotective role. Recent studies such as the Women's Health Initiative (WHI), however, have failed to demonstrate a relationship between conventional hormone replacement therapy (HRT) and protection from CHD. As a result of such studies, many women and physicians have avoided HRT, fearing that it may increase CHD risk.

    We believe that trials such as the WHI failed to demonstrate a cardioprotective effect of female hormones for several reasons: namely, that these trials used forms of hormones that are not biochemically identical to those naturally found in women; that the trials used a "one-size-fits-all" dosing strategy; and that the trials did not cycle hormones to mimic the normal menstrual cycle. Our clinical experience suggests that a more refined form of HRT, which we call hormonorestorative therapy, or hormonorestoration, may indeed offer cardioprotection by helping minimize several CHD risk factors.


    In this article, we examine the principles of hormonorestorative therapy and two case histories in which individualized hormonorestoration helped reduce multiple cardiovascular risk factors in women. Additionally, we review CHD risk factors, symptoms, and diagnosis, along with conventional and integrative strategies for heart disease prevention and treatment. We propose that an individualized strategy of hormonorestorative therapy represents a novel yet powerful approach to reducing CHD risk in women.

    Read the full article . . .
  • Anti-Cancer Benefits of Shark Liver Oil

    By Dale Kiefer

    With their toothsome maws and machine-like killing efficiency, the primitive creatures known as sharks have long inspired fear and commanded respect. But does this ancient family of boneless fish harbor a secret weapon against some of the most dreaded cancers afflicting humans?

    Centuries ago, Scandinavian practitioners of folk medicine adopted the habit of consuming shark liver oil as a general health tonic. In recent decades, scientists have observed that tumors are remarkably rare in sharks, and that these predatory fish are notoriously resistant to infections.1 This amazing imperviousness to disease doubtless inspired the folk remedy.

    Admittedly, fighting disease with shark oil sounds far-fetched. The very notion evokes unsavory images of cure-all tonics and unscrupulous charlatans from centuries past. But in 1952, Dr. Astrid Brohult stumbled upon remarkable proof that shark oil actually works. The fascinating story of her discovery, related by some of her colleagues in the book Shark Liver Oil: Nature's Amazing Healer,2 provides a glimpse at the happy serendipity that occasionally results when science and intuition mix.

    A Hunch Pays Off

    Dr. Brohult was a young Swedish oncologist working with leukemia patients in a children's hospital. Leukemia is a potentially deadly cancer that affects white blood cells, or leukocytes, which are the immune system's front-line defensive players, manufactured in the bone marrow. When leukemia strikes, leukocyte production runs amok.

    To stop the disease, patients are exposed to enough radiation to kill the cells in the bone marrow that give rise to both red and white blood cells. This drastic treatment is usually effective, but occasionally may be worse than the disease itself. With fewer red blood cells to carry oxygen and remove wastes, and few leukocytes left to fight infection and marshal other defenses, patients are rendered weak, deathly ill, and prone to infection.

    In an effort to stimulate her patients' bone marrow to resume normal function, Dr. Brohult administered calve's marrow to the children in her care. She was operating on little more than a hunch. Parents in Scandinavia have long served bone marrow soup to their children in winter, in the belief that it builds strength. Dr. Brohult reasoned that healthy bone marrow from calves might trigger a resumption of healthy function in humans.

    Her hope—and desperation—paid off. Although the results were inconsistent, some of her patients quickly experienced remarkable improvements, including a normalization of white blood cell counts and a striking return of energy.2,3 While exhilarated, Dr. Brohult immediately faced the problem of isolating the active component in the marrow in order to devise a more palatable source of the wondrous substance.

    Read the full article . . .

    Shark Liver Oil

    Cancer Prevention / Therapies
  • Featured Product: SODzyme™ with GliSODin® - Free radicals accelerate aging by damaging cell membranes, proteins, and even DNA. Protecting yourself against the ravages of cell-damaging free radicals is essential to promoting health and longevity.

    The first line of defense against free radical assault is the body's own internally produced antioxidants, including the enzymes superoxide dismutase (SOD), catalase and glutathione peroxidase. Research shows that antioxidant enzymes like SOD offer up to thousands of times more protection against certain dangerous free radicals than do dietary antioxidants.

    The body's supply of youthful antioxidant enzymes such as SOD rapidly decrease with age.1,2 The good news is breakthroughs in nutritional science have enabled researchers to develop an orally ingested supplement that raises and replenishes the body's supply of SOD, thus vastly enhancing its own natural antioxidant defenses.

    Life Extension's SODzyme™ with GliSODin® delivers a "one-two punch" against free radical-generated oxidative stress by combining two of the most advanced SOD catalysts available. In one clinical trial, SODzyme™ significantly increased serum and blood levels of SOD and catalase in supplemented volunteers, while reducing hydrogen peroxide.

    SODzyme™ with GliSODin® also contains 100 milligrams of GliSODin®, a patented, plant-derived form of SOD bonded to the wheat protein gliadin to protect against degradation in the body and enhance absorption. In extensive animal and human trials, GliSODin® has been shown to raise blood levels of the antioxidant enzymes SOD and catalase, helping to maintain healthy cellular DNA structure. 3,4

    Supplement Facts

    Serving Size: 3 vegetarian capsules

    Servings Per Container: 60

    Amount Per Serving
    • SODzyme™ Proprietary Phytoenzyme Blend (Glycine max, Zea mays, wheat sprout concentrate) - 2000 mg
    • Superoxide Dismutase/Gliadin Complex (GliSODin®) [SOD (Superoxide Dismutase) NBT Enzyme Activity = 100 IU] - 100 mg
    Other ingredients: maltodextrin, vegetable cellulose, magnesium stearate, rice flour, cellulose.

    This product contains NO dairy, sugar, artificial colors, sweeteners, flavors or preservatives.

    NBT corresponds to the melon extract quantity inhibiting 50% of NitroBlue Tetrazolium reduction.

    Isocell SA, France is the owner of US Patents Nos. 6,045,809 and 6,426,068B1 and trademark of GliSODin®.

    Dosage and Use: Three capsules early in the day preferably on an empty stomach.

    Caution: Do not take if you are allergic to soy, corn, wheat or gluten.


    1. Abou-Seif, MA, Youssef AA. Evaluation of some biochemical changes in diabetic patients. Clin Chim Acta. 2004 Aug 16;346(2):161-70.

    2. Choi J, Rees HD, Weintraub ST, et al. Oxidative modifications and aggregation of Cu,Zn-superoxide dismutase associated with Alzheimer and Parkinson diseases. J Biol Chem. 2005 Mar 25;280(12):11648-55.

    3. Vouldoukis I, Conti M, Krauss P et al. Supplementation with gliadin-combined plant superoxide dismutase extract promotes antioxidant defences and protects against oxidative stress. Phytother Res. 2004 Dec;18(12):957-62.

    4. Chenal H, Davit-Spraul A, Legrand J, et al. Restored antioxidant circulating capacities in west African AIDS patients receiving an antioxidant nutraceutical Cucumis melo extract rich in superoxide dismutase activity (GliSODin®. (Submitted for publication.)
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