~ 081210 Staying Up Late May Up Heart Disease Risk

United Press International

Staying up until 2 a.m. and upsetting the body's internal clock might come with serious consequences for lipid metabolism, a U.S. researcher suggests.

M. Mahmood Hussain of the State University of New York Downstate Medical Center says circadian rhythm gets thrown off by staying up late or by traveling it may result in high triglycerides -- fatty acids in the blood -- a risk factor for heart disease.

Plasma triglycerides double or triple during the course of the day, reaching their lowest point at night when nocturnal animals eat and are most active.

In a study using normal mice and mice with altered circadian rhythms, the researchers found the normal mice had triglycerides reach a high once a day, while the altered mice had high triglycerides all the time, Hussain says.

"Metabolic syndrome and obesity are major metabolic disorders characterized by high plasma lipid concentrations," the researchers say in a statement. "Plasma lipids are tightly controlled by mechanisms regulating their production and clearance. Here, we show that light-entrained mechanisms involving clock genes also play a role in regulating plasma triglyceride."

The findings, published in the journal Cell Metabolism, may result in drug timing -- finding the best time of day to give medications in controlling disease states.

Copyright United Press International 2010


Free Shipping in the Continental U.S. on Orders over $50
The statements made here have not been evaluated by the FDA. The foregoing statements are based upon sound and reliable studies, and are meant for informational purposes. Consult with your medical practitioner to determine the underlying cause of your symptoms. Please always check your purchase for possible allergins and correct dosage on the bottle before use.

While we work to ensure that product information is correct, on occasion manufacturers may alter their ingredient lists. Actual product packaging and materials may contain more and/or different information than that shown on our Web site. We recommend that you do not solely rely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. For additional information about a product, please contact the manufacturer. Content on this site is for reference purposes and is not intended to substitute for advice given by a physician, pharmacist, or other licensed health-care professional. You should not use this information as self-diagnosis or for treating a health problem or disease. Contact your health-care provider immediately if you suspect that you have a medical problem. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease or health condition. Life Ex Online assumes no liability for inaccuracies or misstatements about products.