~ 061008 Reduced Vitamin D Levels Associated with Heart Attack in Men

The June 9, 2008 issue of the American Medical Association journal Archives of Internal Medicine published the finding of Harvard researchers that men who have deficient vitamin D levels have a greater risk of myocardial infarction (heart attack) than men whose blood levels of the vitamin are sufficient.

For the current study, Edward Giovannucci, MD of Harvard School of Public Health and his associates reviewed data from men aged 40 to 75 who participated in the Health Professionals Follow-up Study, a prospective cohort investigation designed to evaluate associations between chronic disease incidence and diet among male health care professionals. Blood samples collected from 1993 to 1995 were analyzed for plasma 25-hydroxyvitamin D (25-OHD), lipoprotein and triglyceride levels, and diet and lifestyle factors were ascertained though the use of questionnaires. Nine hundred participants without heart disease were matched for age, smoking status, and time of blood collection with 454 men aged 40 to 75 who had fatal coronary heart disease or non-fatal heart attack diagnosed between the time of blood sample collection through January, 2004.

Adjusted analysis of the data found a 2.42 times greater risk of heart attack among subjects with plasma vitamin D levels of 15 nanograms per milliliter or less compared with those whose levels were sufficient at 30 nanograms per milliliter or higher. Even those whose vitamin D levels were intermediate had a 43 to 60 percent greater risk of heart attack compared to men with sufficient levels. Adjustment for a number of factors, such as family history of heart attack, failed to significantly reduce the association. Men with low levels of vitamin D were more likely to live in northern states, and less likely to be white or to use a multivitamin supplement, among other characteristics revealed by the analysis.

In their commentary, the authors cite vitamin D's effect on smooth muscle cell proliferation, inflammation, vascular calcification, and blood pressure via the renin-angiotensin system as possible protective mechanisms against myocardial infarction. Other potential mechanisms include protection against type 2 diabetes, inflammation, and seasonal respiratory tract infections (especially influenza), all of which can impact cardiovascular disease mortality.

"These results further support an important role for vitamin D in myocardial infarction risk," the authors write. "If this association is causal, which remains to be established, the amount of vitamin D required for optimal benefit may be much higher than would be provided by current recommendations (200-600 IU per day), especially in those with minimal sun exposure. Thus, the present findings add further support that the current dietary requirements of vitamin D need to be increased to have an effect on circulating 25(OH)D levels substantially large enough for potential health benefits."

Related Health Concern: Coronary artery disease

People who have risk factors for atherosclerosis should take measures to modify them. The ideal nutritional approach to atherosclerosis takes into consideration all existing risk factors and attempts to modify each one.

The following nutrients have been shown to improve endothelial function and reduce the damage caused by oxidized LDL, slowing the progression of atherosclerosis:

  • Folic acid - 800 to 5000 micrograms (mcg) daily
  • Vitamin B12 - 300 to 2000 mcg daily
  • EPA and DHA - 1400 milligrams (mg) EPA and 1000 mg DHA daily
  • PLC - 1000 to 2000 mg daily
  • L-arginine - 3000 to 12,000 mg daily (in 3 divided doses)
  • Lipoic acid - 150 to 300 mg daily
  • Garlic - 1200 mg daily (Kyolic aged garlic extract)
  • Ginkgo biloba - 120 mg daily
  • Green tea extract - 725 mg daily (93 percent polyphenols)
  • Quercetin - 500 to 1000 mg daily (water-soluble quercetin)
  • Vitamin C - 1000 to 3000 mg daily
  • Vitamin E - 400 international units (IU) daily (with 200 mg gamma tocopherol)
  • Vitamin K - 10 mg daily
  • Vitamin B6 - 100 to 750 mg daily


In addition, bioidentical hormone therapy may be recommended, depending on blood testing results.


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