~ Red Yeast Rice: A Natural Statin to Inhibit Cholesterol Biosynthesis

Chinese red yeast rice has been found to reduce cholesterol, triglyceride and low-density lipoprotein (LDL) levels by inhibiting excessive biosynthesis of cholesterol. Chinese red yeast rice contains naturally occurring substances, such as mevinolin, betasitosterol, stigmasterol, isoflavones, and monounsaturated fatty acids, which account for its beneficial effects.

Chinese red yeast rice is the product of rice on which red yeast (Monascus purpureus) has been fermented. It is known to have been in dietary and medicinal use in China since the Tang Dynasty of the 9th century AD. Its uses have included the production of rice wine, use as a food preservative for fish and meat, and use as a traditional medicine. Traditional Chinese Medicine (TCM) characterizes Chinese red yeast rice as a benign remedy, which promotes healthy circulation.

A number of animal and human studies conducted in China since 1995 showed that red yeast rice consumption resulted in lowered serum cholesterol levels in a range of 11-32% and triglycerides 12-19%. A UCLA study published in the February 1999 American Journal of Clinical Nutrition found that subjects who received 2400 mg daily of red yeast rice experienced significantly reduced cholesterol, triglycerides, and LDL levels after 8 weeks, as compared with placebo.

Researchers observed no adverse effects in test subjects and found no changes in liver and renal function tests conducted before and after the study. Coenzyme Q 10 is a fat-soluble compound primarily synthesized by the body but also consumed in the diet. It is required for mitochondrial ATP synthesis and also functions as an antioxidant in cell membranes and lipoproteins. HMG-CoA reductase is an enzyme that plays a critical role in the regulation of cholesterol synthesis as well as in coenzyme Q 10 synthesis. Statins, widely used cholesterol-lowering substances, are HMG-CoA reductase inhibitors and may decrease the synthesis of endogenous coenzyme Q 10.

A number of studies have observed decreased serum Coenzyme Q 10 levels in people taking statins.   We suggest the following combination of 2400mg Red Yeast Rice and 60mg (at least) of CoQ10 as the safest, most efficient method to raise hdl and lower ldl.
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