~ 022908 Rats Find "Expensive Urine" Pays Off

In the March 1, 2008 issue of the AACR journal Cancer Research, Roswell Park Cancer Institute professor of oncology Yuesheng Zhang, MD, PhD and his colleagues report that an extract of broccoli sprouts given to rats reduced the development of bladder tumors by one half.

Dr Zhang's team gave groups of rats a high or low dose of a concentrated extract of freeze dried broccoli sprouts two weeks prior to adding the carcinogen BBN to their drinking water. Other groups of animals received the broccoli sprout extract only, BBN only, or neither substance.

Bladder tumors did not develop in the group that received the broccoli sprout extract alone (without BBN), or who received neither treatment, however, among animals that received the carcinogen alone, 96 percent developed at least two tumors. Although 74 percent of BBN-treated rats that received the low dose of broccoli sprout extract developed cancerous tumors, only 38 percent of those that received the high dose developed any, and their tumors were much smaller in size and less numerous than those of the other groups.

The protective effect of broccoli and other cruciferous vegetables such as cabbage appears to be the result of their isothiocyanate (ITC) content. These phytochemicals have been associated with cancer protection in numerous other studies. Broccoli sprouts contain 30 times more ITCs than mature broccoli, and the compound used in the study provides 600 times more.

"Although this is an animal study, it provides potent evidence that eating vegetables is beneficial in bladder cancer prevention," Dr Zhang stated. "The bladder is particularly responsive to this group of natural chemicals. In our experiments, the broccoli sprout ITCs after oral administration were selectively delivered to the bladder tissues through urinary excretion."

"Epidemiologic studies have shown that dietary ITCs and cruciferous vegetable intake are inversely associated with bladder cancer risk in humans," he added. "It is possible that ITC doses much lower than those given to the rats in this study may be adequate for bladder cancer prevention."

Related Health Concern: Complementary alternative cancer therapies

Complementary alternative medical therapies (CAM) is a collective term for an array of remedies that lie outside what is traditionally considered conventional medical treatment for cancer. These include the use of herbal, vitamin, and nutritional supplements, as well as physical and psychological interventions such as exercise, relaxation, massage, prayer, hypnotherapy, and acupuncture (Deng G et al 2005; Hann D et al 2005; Molassiotis A et al 2005). The use of CAM as a component of integrated cancer treatment regimens may help patients reduce the side effects associated with conventional cancer treatments, alleviate symptoms, enhance immune function, and provide greater quality of (and control over) life (Deng G et al 2004, 2005).

Natural strategies known to prevent the development and progression of cancer include:

  • Calcium
  • Carotenoids
  • Curcumin
  • Garlic
  • Green and black teas
  • Folic acid
  • Melatonin
  • Selenium
  • Silymarin
  • Vitamin A
  • Vitamin C
  • Vitamin D
  • Vitamin E
  • Vitamin K the highest soy intake were less like to suffer from fractures.


Free Shipping in the Continental U.S. on Orders over $50
The statements made here have not been evaluated by the FDA. The foregoing statements are based upon sound and reliable studies, and are meant for informational purposes. Consult with your medical practitioner to determine the underlying cause of your symptoms. Please always check your purchase for possible allergins and correct dosage on the bottle before use.

While we work to ensure that product information is correct, on occasion manufacturers may alter their ingredient lists. Actual product packaging and materials may contain more and/or different information than that shown on our Web site. We recommend that you do not solely rely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. For additional information about a product, please contact the manufacturer. Content on this site is for reference purposes and is not intended to substitute for advice given by a physician, pharmacist, or other licensed health-care professional. You should not use this information as self-diagnosis or for treating a health problem or disease. Contact your health-care provider immediately if you suspect that you have a medical problem. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease or health condition. Life Ex Online assumes no liability for inaccuracies or misstatements about products.