~ 020612 Novel Magnesium Compound Reverses Neurodegeneration - References


1. Alzheimer's Association. 2008 Alzheimer's disease facts and figures. Alzheimers Dement. 2008 Mar;4(2):110-33.

2. Hudson AP, Balin BJ, Crutcher K, Robinson S. New thinking on the etiology and pathogenesis of late-onset Alzheimer's disease. Int J Alzheimers Dis. 2011;2011:848395.

3. Available at: http://www.alz.org/downloads/Facts_Figures_2011.pdf. Accessed September 28, 2011.

4. Ballard C, Gauthier S, Corbett A, Brayne C, Aarsland D, Jones E. Alzheimer's disease. Lancet. 2011 Mar 19;377(9770):1019-31.

5. Holtzman DM, Morris JC, Goate AM. Alzheimer's disease: the challenge of the second century. Sci Transl Med. 2011 Apr 6;3(77):77sr1.

6. Available at: http://report.nih.gov/NIHfactsheets/ViewFactSheet.aspx?csid=107. Accessed September 28, 2011.

7. Available at: http://www.mit.edu/press/2010/magnesium-supplement.html. Accessed September 28, 2011.

8. Slutsky I, Abumaria N, Wu LJ, et al. Enhancement of learning and memory by elevating brain magnesium. Neuron. 2010 Jan 28;65(2):165-77.

9. Barbagallo M, Belvedere M, Dominguez LJ. Magnesium homeostasis and aging. Magnes Res. 2009 Dec;22(4):235-46.

10. Barbagallo M, Dominguez LJ. Magnesium and aging. Curr Pharm Des. 2010;16(7):832-9.

11. Rude RK, Singer FR, Gruber HE. Skeletal and hormonal effects of magnesium deficiency. J Am Coll Nutr. 2009 Apr;28(2):131-41.

12. Bush AI. Kalzium ist nicht alles. Neuron. 2010 Jan 28;65(2):143-4.

13. Bardgett ME, Schultheis PJ, McGill DL, Richmond RE, Wagge JR. Magnesium deficiency impairs fear conditioning in mice. Brain Res. 2005 Mar 15;1038(1):100-6.

14. Slutsky I, Sadeghpour S, Li B, Liu G. Enhancement of synaptic plasticity through chronically reduced Ca2+ flux during uncorrelated activity. Neuron. 2004 Dec 2;44(5):835-49.

15. Malenka RC, Nicoll RA. NMDA-receptor-dependent synaptic plasticity: multiple forms and mechanisms. Trends Neurosci. 1993 Dec;16(12):521-7.

16. MacDonald JF, Jackson MF, Beazely MA. Hippocampal long-term synaptic plasticity and signal amplification of NMDA receptors. Crit Rev Neurobiol. 2006;18(1-2):71-84.

17. Kalantzis G, Shouval HZ. Structural plasticity can produce metaplasticity. PLoS One. 2009 Nov 30;4(11):e8062.

18. Rasmussen HH, Mortensen PB, Jensen IW. Depression and magnesium deficiency. Int J Psychiatry Med. 1989;19(1):57-63.

19. Hoane MR, Gilbert DR, Barbre AB, Harrison SA. Magnesium dietary manipulation and recovery of function following controlled cortical damage in the rat. Magnes Res. 2008 Mar;21(1):29-37.

20. Killilea DW, Ames BN. Magnesium deficiency accelerates cellular senescence in cultured human fibroblasts. Proc Natl Acad Sci U S A. 2008 Apr 15;105(15):5768-73.

21. Assadi F. Hypomagnesemia: an evidence-based approach to clinical cases. Iran J Kidney Dis. 2010 Jan;4(1):13-9.

22. McKee JA, Brewer RP, Macy GE, et al. Analysis of the brain bioavailability of peripherally administered magnesium sulfate: A study in humans with acute brain injury undergoing prolonged induced hypermagnesemia. Crit Care Med. 2005 Mar;33(3):661-6.

23. Win-Shwe TT, Fujimaki H. Acute administration of toluene affects memory retention in novel object recognition test and memory function-related gene expression in mice. J Appl Toxicol. 2011 May 24.

24. Bi GQ, Poo MM. Synaptic modifications in cultured hippocampal neurons: dependence on spike timing, synaptic strength, and postsynaptic cell type. J Neurosci. 1998 Dec 15;18(24):10464-72.

25. Martin SJ, Grimwood PD, Morris RG. Synaptic plasticity and memory: an evaluation of the hypothesis. Annu Rev Neurosci. 2000;23:649-711.

26. Tang YP, Shimizu E, Dube GR, et al. Genetic enhancement of learning and memory in mice. Nature. 1999 Sep 2;401(6748):63-9.

27. Bliss TV, Collingridge GL. A synaptic model of memory: long-term potentiation in the hippocampus. Nature. 1993 Jan 7;361(6407): 31-9.

28. Cooke SF, Bliss TV. Plasticity in the human central nervous system. Brain. 2006 Jul;129(Pt 7):1659-73.

29. Wilson IA, Gallagher M, Eichenbaum H, Tanila H. Neurocognitive aging: prior memories hinder new hippocampal encoding. Trends Neurosci. 2006 Dec;29(12):662-70.

30. Burke SN, Barnes CA. Neural plasticity in the ageing brain. Nat Rev Neurosci. 2006 Jan;7(1):30-40.

31. Smith TD, Adams MM, Gallagher M, Morrison JH, Rapp PR. Circuit-specific alterations in hippocampal synaptophysin immunoreactivity predict spatial learning impairment in aged rats. J Neurosci. 2000 Sep 1;20(17):6587-93.

32. Duguid IC, Smart TG. Presynaptic NMDA receptors. In: Van Dongen AM, ed. Biology of the NMDA Receptor. Boca Raton, FL: CRC Press; 2009.

33. Abumaria N, Yin B, Zhang L, Zhao L, Liu G. Enhancement of cognitive control of emotions by elevated brain magnesium leads to anti-depressants like effect. Poster presentation #549. Society for Neuroscience 2009 Meeting. October 20, 2009. Chicago, IL.

34. Abumaria N, Yin B, Zhang L, et al. Effects of elevation of brain magnesium on fear conditioning, fear extinction, and synaptic plasticity in the infralimbic prefrontal cortex and lateral amygdala. J Neurosci. 2011 Oct 19;31(42):14871-81.

35. Brown TH, Chapman PF, Kairiss EW, Keenan CL. Long-term synaptic potentiation. Science. 1988 Nov 4;242(4879):724-8.

36. Ostroff LE, Cain CK, Jindal N, Dar N, Ledoux JE. Stability of presynaptic vesicle pools and changes in synapse morphology in the amygdala following fear learning in adult rats. J Comp Neurol. 2011 Jun 14.

37. Bertoni-Freddari C, Fattoretti P, Paoloni R, Caselli U, Galeazzi L, Meier-Ruge W. Synaptic structural dynamics and aging. Gerontology. 1996;42(3):170-80.

38. Pereira C, Agostinho P, Moreira PI, Cardoso SM, Oliveira CR. Alzheimer's disease-associated neurotoxic mechanisms and neuroprotective strategies. Curr Drug Targets CNS Neurol Disord. 2005 Aug;4(4):383-403.

39. Scheff SW, Price DA, Schmitt FA, Mufson EJ. Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment. Neurobiol Aging. 2006 Oct;27(10):1372-84.

40. Arendt T. Synaptic degeneration in Alzheimer's disease. Acta Neuropathol. 2009 Jul;118(1):167-79.

41. Gomez-Pinilla F. Brain foods: the effects of nutrients on brain function. Nat Rev Neurosci. 2008 Jul;9(7):568-78.

42. Wurtman RJ, Cansev M, Sakamoto T, Ulus I. Nutritional modifiers of aging brain function: use of uridine and other phosphatide precursors to increase formation of brain synapses. Nutr Rev. 2010 Dec;68 Suppl 2:S88-101.

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