~ 011307 Study Shows Magnesium Supplementation Increases Bone Density in Young Girls

A study conducted at the Clinical Research Centers at Yale University School of Medicine and published in the Journal of Clinical Endocrinology & Metabolism (91, 12: 4866-4872) found that high Magnesium intake by girls during their pre-puberty through mid-teen years, significantly increased bone mineral density of the hip bone and, to a lesser degree, the lumbar spine.

This prospective, placebo-controlled, randomized, one-year double blind trial included healthy Caucasian girls aged 8 to 14 years, drawn from local pediatrician practices. Dietary diaries of more than 120 potential subjects were analyzed, and those with an estimated dietary Magnesium intake of less than 220 mg per day were invited to participate in the trial. Participants received either a supplement of 300 mg per day of elemental Magnesium (as oxide, divided into two daily doses) or placebo for 12 months.

There was a significant increase in bone mineral density in the hip bone in the Magnesium supplemented group as compared to placebo. The Lumbar spinal bone density increase was slightly (but not significantly) greater in the Magnesium supplemented group than placebo.

Researchers considered participant compliance to be excellent with 73% of capsules ingested. Serum mineral levels, calciotropic hormones, and bone markers were similar between groups. Researchers concluded that a positive effect of Magnesium supplementation on hip bone mineral density was demonstrated, even with this small cohort, and that oral Magnesium supplementation was safe and well tolerated.


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