Circadian Sleep combines melatonin with a novel citrus peel extract to encourage healthy function of both central and peripheral circadian clocks, respectively. MicroActive® Melatonin promotes optimal sleep-wake cycles, and nobiletin from young citrus peel supports healthy expression of genes that govern peripheral circadian rhythms.

More facts about Circadian Sleep

Aging, hectic modern lifestyles and other factors can disrupt our circadian clocks, which can affect our health.^1-3 So we developed our Circadian Sleep formula to restore these natural rhythms: MicroActive® Melatonin supports the central clock in the brain, while nobiletin young citrus peel extract promotes healthy peripheral clocks, which control the rest of the body.

Melatonin for healthy sleep-wake cycling

Peripheral circadian clocks exist in virtually every cell of our bodies and are organized hierarchically, with the central clock setting the pace by regulating healthy sleep-wake cycles.⁴ Melatonin, known as the “sleep hormone,” is primarily synthesized at night in the brain by the pineal gland.⁵ Melatonin ensures that the central clock is properly supporting sleep-wake cycles and aligning the peripheral clocks with the sleep-wake cycles for whole-body health.

The first step to healthy, whole-body circadian rhythms is to restore that central clock with melatonin.

Nobiletin for healthy peripheral circadian rhythms

Peripheral circadian clocks in various organs govern essential biological processes: heart rate, body temperature, hormone release, blood pressure, liver, kidney and pancreatic function and more.^6-8 Nobiletin is a polymethoxylated flavone isolated from young citrus peel. Results from a recent pre-clinical study suggest that nobiletin may also help positively support peripheral circadian rhythms.⁹ It does so by directly activating a unique set of receptors widely expressed throughout the body and known to play a key role in supporting circadian rhythms.^10-14 It has also been shown to exhibit neuroprotective and antioxidant properties as well as promote a healthy inflammatory response.¹⁵

Nobiletin promotes whole-body health

In another pre-clinical study, nobiletin supports the expression of circadian genes which themselves control the expression of other genes with specific circadian functions in every cell.¹⁶ Healthy expression of genes controlling circadian rhythms supports metabolic, cognitive, liver and kidney health and also helps maintain healthy blood pressure, cholesterol and triglyceride levels already within the normal range.^17-20

Innovative circadian health formula

By supporting both “central” and “peripheral” circadian clocks, our Circadian Sleep represents an innovative, restorative approach to whole-body health. Try Circadian Sleep today!

Dosage and Use Take one (1) capsule daily, before bedtime, or as recommended by a healthcare practitioner. Melatonin is naturally secreted from the pineal gland at night, and should be taken at night for optimal results.

Restore circadian rhythms for sleep & overall health