~ Protecting Your DNA from Lethal Mutations - References


1. Liska DJ. The detoxification enzyme systems. Altern Med Rev. 1998 Jun;3(3):187-98.

2. Hietanen E, Linnainmaa K, Vainio H. Effects of phenoxyherbicides and glyphosate and the hepatic and intestinal biotransformation activities in the rat. Acta Pharmacol Toxicol (Copenh.). 1983 Aug; 53(2):103-12.

3. Dashwood RH. Use of transgenic and mutant animal models in the study of heterocyclic amine-induced mutagenesis and carcinogenesis. J Biochem Mol Biol. 2003 Jan 31;36(1):35-42.

4. Shishu, Singla AK, Kaur IP. Inhibitory effect of curcumin and its natural analogues on genotoxicity of heterocyclic amines from cooked food. Indian J Exp Biol. 2002 Dec;40(12):1365-72.

5. Rao CV, Rivenson A, Simi B, Reddy BS. Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound. Cancer Res. 1995 Jan 15;55(2):259-66.

6. Kawamori T, Lubet R, Steele VE, et al. Chemopreventive effect of curcumin, a naturally occurring anti-inflammatory agent, during the promotion/progression stages of colon cancer. Cancer Res. 1999 Feb 1;59(3):597-601.

7. Limtrakul P, Lipigorngoson S, Namwong O, Apisariyakul A, Dunn FW. Inhibitory effect of dietary curcumin on skin carcinogenesis in mice. Cancer Lett. 1997 Jun 24;116(2):197-203.

8. Limtrakul P, Anuchapreeda S, Lipigorngoson S, Dunn FW. Inhibition of carcinogen induced c-Ha-ras and c-fos proto-oncogenes expression by dietary curcumin. BMC Cancer. 2001 Jan;1(1):1.

9. Limtrakul P, Anachapreeda S, Buddhasukh D. Modulation of human multidrug-resistance MDR-1 gene by natural curcuminoids. BMC Cancer. 2004 Apr 17;4(1):13.

10. Mehta K, Pantazis P, McQueen T, Aggarwal BB. Antiproliferative effect of curcumin (diferuloylmethane) against human breast cancer tumor cell lines. Anticancer Drugs. 1997 Jun;8(5):470-81.

11. Susan M, Rao MN. Induction of glutathione S-transferase activity by curcumin in mice. Arzneimittelforschung. 1992 Jul;42(7):962-4.

12. Iqbal M, Sharma SD, Okazaki Y, Fujisawa M, Okada S. Dietary supplementation of curcumin enhances antioxidant and Phase II metabolizing enzymes in ddY male mice: possible role in protection against chemical carcinogenesis and toxicity. Pharmacol Toxicol. 2003 Jan;92(1):33-8.

13. Sreejayan N, Rao MN. Nitric oxide scavenging by curcuminoids. J Pharm Pharmacol. 1997 Jan;49(1):105-7.

14. Sreejavan N, Rao MN. Free radical scavenging activity of curcuminoids. Arzneimittelforschung. 1996 Feb;46(2):169-71.

15. Subramanian M, Sreejavan N, Rao MN, Devasagayam TP, Singh BB. Diminution of singlet oxygen-induced DNA damage by curcumin and related antioxidants. Mutat Res. 1994 Dec 1;311(2):249-55.

16. Aggarwal BB, Kumar A, Bharti AC. Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res. 2003 Jan-Feb;23(1A):363-98.

17. Ong TM, Whong WZ, Stewart J, Brockman HE. Chlorophyllin: a potent anti-mutagen against environmental and dietary complex mixtures. Mutat Res. 1986 Feb;173(2):111-5.

18. Dashwood RH, Xu M, Orner GA, Horio DT. Colonic cell proliferation, apoptosis and aberrant crypt foci development in rats given 2-amino-3-methylimidazo[4,5-f]quinoline and treated post-initiation with chlorophyllin. Eur J Cancer Prev. 2001 Apr;10(2):139-45.

19. Xu M, Orner GA, Bailey GS, Stoner GD, Horio DT, Dashwood RH. Post-initiation effects of chlorophyllin and indole-3-carbinol in rats given 1,2-dimethylhydrazine or 2-amino-3-methyl-imidazo. Carcinogenesis. 2001 Feb;22(2):309-14.

20. Madrigal-Bujaidar E, Velazquez-Guadarrama N, Diaz-Barriga S. Inhibitory effect of chlorophyllin on the frequency of sister chromatid exchanges produced by benzo[a]pyrene in vivo. Mutat Res. 1997 Jan 15;388(1):79-83.

21. Carter O, Bailey GS, Dashwood RH. The dietary phytochemical chlorophyllin alters E-cadherin and beta-catenin expression in human colon cancer cells. J Nutr. 2004 Dec;134(12 Suppl):3441S-4S.

22. Kinae N, Masuda H, Shin IS, Furugori M, Shimoi K. Functional properties of wasabi and horseradish. Biofactors. 2000;13(1-4):265-9.

23. Morimitsu Y, Hayashi K, Nakagawa Y, Horio F, Uchida K, Osawa T. Antiplatelet and anticancer isothiocyanates in Japanese domestic horseradish, wasabi. Biofactors. 2000;13(1-4):271-6.

24. Watanabe M, Ohata M, Hayakawa S, et al. Identification of 6-methylsulfinyhexyl isothiocyanate as an apoptosis-inducing component in wasabi. Phytochemistry. 2003 Mar;62(5):733-9.

25. Xu K, Thornalley PJ. Studies on the mechanism of the inhibition of human leukaemia cell growth by dietary isothiocyanates and their cysteine adducts in vitro. Biochem Pharmacol. 2000 Jul 15;60(2):221-31.

26. Nomura T, Shinoda S, Yamori T, et al. Selective sensitivity to wasabi-derived 6-(methylsulfiny)hexyl isothiocyanate of human breast cancer and melanoma cell lines studies in vitro. Cancer Detect Prev. 2005;29(2):155-60.

27. Morimitsu Y, Nakagawa Y, Hayashi K, et al. A sulforaphane analogue that potently activates the Nrf2-dependent detoxification pathway. J Biol Chem. 2002 Feb 1;277(5):3456-63.

28. Morse MA, Zu H, Galati AJ, Schmidt CJ, Stoner GD. Dose-related inhibition by dietary phenethyl isothiocyanate of esophageal tumorigenesis and DNA methylation induced by N-nitrosomethylbenzylamine in rats. Cancer Lett. 1993 Aug 16;72(1-2):103-10.

29. Doerr-O'Rourke K, Trushin N, Hecht SS, Stoner GD. Effect of phenethyl isothiocyanate on the metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by cultured rat lung tissue. Carcinogenesis. 1991 Jun;12(6):1029-34.

30. Hecht SS. Chemoprevention by isothiocyanates. J Cell Biochem Suppl. 1995;22:195-209.

31. Shapiro TA, Fahey JW, Wade KL, Stephenson KK, Talalay P. Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: metabolism and excretion in humans. Cancer Epidemiol Biomarkers Prev. 2001 May;10(5):501-8.

32. Zhang Y, Talalay P, Cho CG, Posner GH. A major inducer of anti-carcinogenic protective enzymes from broccoli: isolation and elucidation of structure. Proc Natl Acad Sci USA. 1992 Mar 15;89(6):2399-403.

33. Zhang Y, Kensler TW, Cho CG, Posner GH, Talalay P. Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates. Proc Natl Acad Sci USA. 1994 Apr 12;91(8):3147-50.

34. Brooks JD, Paton VG, Vidanes G. Potent induction of phase 2 enzymes in human prostate cells by sulforaphane. Cancer Epidemiol Biomarkers Prev. 2001 Sep;10(9):949-54.

35. Martinez A, Camero II, Ikken Y, Marin ML, Haza AI, Morales P. Protective effect of broccoli, onion, carrot, and licorice extracts against cytotoxicity of N-nitrosamines evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. J Agric Food Chem. 1998 Feb 16;46(2):585-9.

36. Fahey JW, Haristoy X, Dolan PM, et al. Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors. Proc Natl Acad Sci USA. 2002 May 28;99(11):7610-5.

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