~ Protecting Your DNA from Lethal Mutations - References

References

1. Liska DJ. The detoxification enzyme systems. Altern Med Rev. 1998 Jun;3(3):187-98.

2. Hietanen E, Linnainmaa K, Vainio H. Effects of phenoxyherbicides and glyphosate and the hepatic and intestinal biotransformation activities in the rat. Acta Pharmacol Toxicol (Copenh.). 1983 Aug; 53(2):103-12.

3. Dashwood RH. Use of transgenic and mutant animal models in the study of heterocyclic amine-induced mutagenesis and carcinogenesis. J Biochem Mol Biol. 2003 Jan 31;36(1):35-42.

4. Shishu, Singla AK, Kaur IP. Inhibitory effect of curcumin and its natural analogues on genotoxicity of heterocyclic amines from cooked food. Indian J Exp Biol. 2002 Dec;40(12):1365-72.

5. Rao CV, Rivenson A, Simi B, Reddy BS. Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound. Cancer Res. 1995 Jan 15;55(2):259-66.

6. Kawamori T, Lubet R, Steele VE, et al. Chemopreventive effect of curcumin, a naturally occurring anti-inflammatory agent, during the promotion/progression stages of colon cancer. Cancer Res. 1999 Feb 1;59(3):597-601.

7. Limtrakul P, Lipigorngoson S, Namwong O, Apisariyakul A, Dunn FW. Inhibitory effect of dietary curcumin on skin carcinogenesis in mice. Cancer Lett. 1997 Jun 24;116(2):197-203.

8. Limtrakul P, Anuchapreeda S, Lipigorngoson S, Dunn FW. Inhibition of carcinogen induced c-Ha-ras and c-fos proto-oncogenes expression by dietary curcumin. BMC Cancer. 2001 Jan;1(1):1.

9. Limtrakul P, Anachapreeda S, Buddhasukh D. Modulation of human multidrug-resistance MDR-1 gene by natural curcuminoids. BMC Cancer. 2004 Apr 17;4(1):13.

10. Mehta K, Pantazis P, McQueen T, Aggarwal BB. Antiproliferative effect of curcumin (diferuloylmethane) against human breast cancer tumor cell lines. Anticancer Drugs. 1997 Jun;8(5):470-81.

11. Susan M, Rao MN. Induction of glutathione S-transferase activity by curcumin in mice. Arzneimittelforschung. 1992 Jul;42(7):962-4.

12. Iqbal M, Sharma SD, Okazaki Y, Fujisawa M, Okada S. Dietary supplementation of curcumin enhances antioxidant and Phase II metabolizing enzymes in ddY male mice: possible role in protection against chemical carcinogenesis and toxicity. Pharmacol Toxicol. 2003 Jan;92(1):33-8.

13. Sreejayan N, Rao MN. Nitric oxide scavenging by curcuminoids. J Pharm Pharmacol. 1997 Jan;49(1):105-7.

14. Sreejavan N, Rao MN. Free radical scavenging activity of curcuminoids. Arzneimittelforschung. 1996 Feb;46(2):169-71.

15. Subramanian M, Sreejavan N, Rao MN, Devasagayam TP, Singh BB. Diminution of singlet oxygen-induced DNA damage by curcumin and related antioxidants. Mutat Res. 1994 Dec 1;311(2):249-55.

16. Aggarwal BB, Kumar A, Bharti AC. Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res. 2003 Jan-Feb;23(1A):363-98.

17. Ong TM, Whong WZ, Stewart J, Brockman HE. Chlorophyllin: a potent anti-mutagen against environmental and dietary complex mixtures. Mutat Res. 1986 Feb;173(2):111-5.

18. Dashwood RH, Xu M, Orner GA, Horio DT. Colonic cell proliferation, apoptosis and aberrant crypt foci development in rats given 2-amino-3-methylimidazo[4,5-f]quinoline and treated post-initiation with chlorophyllin. Eur J Cancer Prev. 2001 Apr;10(2):139-45.

19. Xu M, Orner GA, Bailey GS, Stoner GD, Horio DT, Dashwood RH. Post-initiation effects of chlorophyllin and indole-3-carbinol in rats given 1,2-dimethylhydrazine or 2-amino-3-methyl-imidazo. Carcinogenesis. 2001 Feb;22(2):309-14.

20. Madrigal-Bujaidar E, Velazquez-Guadarrama N, Diaz-Barriga S. Inhibitory effect of chlorophyllin on the frequency of sister chromatid exchanges produced by benzo[a]pyrene in vivo. Mutat Res. 1997 Jan 15;388(1):79-83.

21. Carter O, Bailey GS, Dashwood RH. The dietary phytochemical chlorophyllin alters E-cadherin and beta-catenin expression in human colon cancer cells. J Nutr. 2004 Dec;134(12 Suppl):3441S-4S.

22. Kinae N, Masuda H, Shin IS, Furugori M, Shimoi K. Functional properties of wasabi and horseradish. Biofactors. 2000;13(1-4):265-9.

23. Morimitsu Y, Hayashi K, Nakagawa Y, Horio F, Uchida K, Osawa T. Antiplatelet and anticancer isothiocyanates in Japanese domestic horseradish, wasabi. Biofactors. 2000;13(1-4):271-6.

24. Watanabe M, Ohata M, Hayakawa S, et al. Identification of 6-methylsulfinyhexyl isothiocyanate as an apoptosis-inducing component in wasabi. Phytochemistry. 2003 Mar;62(5):733-9.

25. Xu K, Thornalley PJ. Studies on the mechanism of the inhibition of human leukaemia cell growth by dietary isothiocyanates and their cysteine adducts in vitro. Biochem Pharmacol. 2000 Jul 15;60(2):221-31.

26. Nomura T, Shinoda S, Yamori T, et al. Selective sensitivity to wasabi-derived 6-(methylsulfiny)hexyl isothiocyanate of human breast cancer and melanoma cell lines studies in vitro. Cancer Detect Prev. 2005;29(2):155-60.

27. Morimitsu Y, Nakagawa Y, Hayashi K, et al. A sulforaphane analogue that potently activates the Nrf2-dependent detoxification pathway. J Biol Chem. 2002 Feb 1;277(5):3456-63.

28. Morse MA, Zu H, Galati AJ, Schmidt CJ, Stoner GD. Dose-related inhibition by dietary phenethyl isothiocyanate of esophageal tumorigenesis and DNA methylation induced by N-nitrosomethylbenzylamine in rats. Cancer Lett. 1993 Aug 16;72(1-2):103-10.

29. Doerr-O'Rourke K, Trushin N, Hecht SS, Stoner GD. Effect of phenethyl isothiocyanate on the metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by cultured rat lung tissue. Carcinogenesis. 1991 Jun;12(6):1029-34.

30. Hecht SS. Chemoprevention by isothiocyanates. J Cell Biochem Suppl. 1995;22:195-209.

31. Shapiro TA, Fahey JW, Wade KL, Stephenson KK, Talalay P. Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: metabolism and excretion in humans. Cancer Epidemiol Biomarkers Prev. 2001 May;10(5):501-8.

32. Zhang Y, Talalay P, Cho CG, Posner GH. A major inducer of anti-carcinogenic protective enzymes from broccoli: isolation and elucidation of structure. Proc Natl Acad Sci USA. 1992 Mar 15;89(6):2399-403.

33. Zhang Y, Kensler TW, Cho CG, Posner GH, Talalay P. Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates. Proc Natl Acad Sci USA. 1994 Apr 12;91(8):3147-50.

34. Brooks JD, Paton VG, Vidanes G. Potent induction of phase 2 enzymes in human prostate cells by sulforaphane. Cancer Epidemiol Biomarkers Prev. 2001 Sep;10(9):949-54.

35. Martinez A, Camero II, Ikken Y, Marin ML, Haza AI, Morales P. Protective effect of broccoli, onion, carrot, and licorice extracts against cytotoxicity of N-nitrosamines evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. J Agric Food Chem. 1998 Feb 16;46(2):585-9.

36. Fahey JW, Haristoy X, Dolan PM, et al. Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors. Proc Natl Acad Sci USA. 2002 May 28;99(11):7610-5.


Free Shipping in the Continental U.S. on Orders over $50
The statements made here have not been evaluated by the FDA. The foregoing statements are based upon sound and reliable studies, and are meant for informational purposes. Consult with your medical practitioner to determine the underlying cause of your symptoms. Please always check your purchase for possible allergins and correct dosage on the bottle before use.

While we work to ensure that product information is correct, on occasion manufacturers may alter their ingredient lists. Actual product packaging and materials may contain more and/or different information than that shown on our Web site. We recommend that you do not solely rely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. For additional information about a product, please contact the manufacturer. Content on this site is for reference purposes and is not intended to substitute for advice given by a physician, pharmacist, or other licensed health-care professional. You should not use this information as self-diagnosis or for treating a health problem or disease. Contact your health-care provider immediately if you suspect that you have a medical problem. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease or health condition. Life Ex Online assumes no liability for inaccuracies or misstatements about products.