~ May 2005 - Slim Down for Summer
Contents . . .
- The Hows and Whys of Weight Loss
As people age, they often accumulate excess body fat. Weight gain not only creates cosmetic problems, but it also contributes to disorders such as Type II diabetes, cardiovascular disease, cartilage breakdown, sexual dysfunction, and even cancer.
Carrying extra pounds has a profound impact on our health and well-being. Perhaps the most devastating emotional impact of being overweight comes from the frustration of continued dieting without success or ending up heavier than ever after following a diet.
Typical approaches to conventional weight loss have a high failure rate. However, the scientific literature provides data indicating that sustained weight management is attainable.
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- 7-Keto DHEA The Fat-Burning Metabolite of DHEA
By Dave Tuttle
While many anti-aging enthusiasts are familiar with the hormone DHEA (dehydroepiandrosterone), far fewer are likely to be aware of its metabolite, 7-Keto DHEA, which is responsible for many of DHEA's beneficial actions.
Scientists have documented DHEA's wide-ranging benefits in numerous clinical studies. DHEA helps to retard the effects of aging and promotes enhanced longevity, exerting a multitude of effects through its conversion to some 150 metabolites, each with unique actions within the body.
One of the most important of these is 7-Keto DHEA (commonly referred to as 7-Keto), a hormone metabolite that can safely boost immune function and help reduce body fat. Unlike DHEA, however, 7-Keto does not convert to estrogen and testosterone. Because DHEA and 7-Keto have separate and unique functions and properties, it is important to understand the differences between these two popular dietary supplements.
Fast-Acting and Safe
The term 7-Keto is in fact a brand name for the chemical compound 3-acetyl-7-oxo-dehydroepiandros-terone, a naturally occurring metabolite primarily produced in the adrenal glands and skin (though some production occurs in the brain as well). It was first discovered in 1958, when it was found in urine.1 Human blood levels of 7-Keto tend to follow the same course over time as those of DHEA, rising until about the age of 20 and then slowly descending beginning around the age of 30. Urinary excretion studies show that average blood concentrations of 7-Keto decline nearly 50% by age 50.
"This reduction in 7-Keto levels is partially responsible for the increases in body fat and total body weight often seen in older people," notes Dr. Sergey Dzugan, president of Life Extension Scientific Information, Inc. "This decline also plays a role in the compromised immune function that is a hallmark of the aging process. Moreover, since DHEA and 7-Keto decline at a more rapid rate than cortisol, this creates a period of cortisol dominance that can wreak havoc on the immune system. For these reasons, supplementation with 7-Keto is often appropriate."
Another benefit to 7-Keto is that it does not convert to estrogen or testosterone. This makes 7-Keto a safe alternative for persons with hormone-sensitive cancers, for whom regular DHEA may be too risky."
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- Research Confirms Benefits of Fiber for Weight Loss, Lower Cholesterol, and Reduced Blood Glucose
By Stephen Laifer
Recent interest in the importance of including fiber in the diet belies the fact that nutritional specialists have advocated its benefits for more than half a century. Even before the fifth century BC, the Greek physician Hippocrates, often regarded as the father of Western medicine, recommended consuming fiber-rich natural foods. In 1953, nutritionist E. H. Hipsley introduced the term "dietary fiber" to represent intake of the indigestible components of plant cell walls.
A more precise definition of fiber was established in 1969, as prevailing nutritional habits were linked with the prevalence of various diseases. In their study of traditional foods consumed by different cultures, Drs. Hugh Trowell and Dennis Burkitt noted that cultures with diets rich in plant foods rarely suffered from illnesses like diabetes, cancer, and cardiovascular disease. By contrast, these diseases had become widespread in developed Western societies in the late 1800s with the advent of a milling technique that produced a new, fiber-depleted dietary staple: white flour. Fiber, they therefore reasoned, might offer protection against many of the diseases prevalent in modern Western societies.
These early nutrition research findings have been borne out by countless subsequent studies. One recent study found that every additional 10 grams of fiber consumed on a daily basis cuts the risk of coronary heart disease death by 27%. Modern medicine recognizes fiber—the edible parts of plants that are resistant to digestion and absorption in the human small intestine—to be an essential component in maintaining a healthy body. Today, a growing body of research is examining one of fiber's least-publicized benefits: its ability to help reduce caloric intake and thus maintain a healthy weight.
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- WARNING! Normal Blood Pressure May Be High Blood Pressure!
By William Davis, MD, FACC, May 2005
To Solve Hypertension, Address Metabolic Syndrome
Metabolic syndrome is by far the leading trigger for hypertension today. It is also a very correctable cause. Correcting metabolic syndrome can have a tremendous impact on blood pressure. The most powerful way to regain control of multifaceted metabolic syndrome is to lose weight, and there are many ways to do it. People with metabolic syndrome respond especially well to diets that restrict carbohydrates and focus on low "glycemic index" foods that blunt the release of blood sugar. Several low-carb diets are very popular now, largely due to the exaggerated success of carbohydrate restriction in a world overrun with metabolic syndrome.
These diets come in a variety of names and packages, including Atkins, South Beach, Zone, and others. If you succeed in losing weight on any of these programs, you are very likely to reduce your blood pressure enough (frequently by 10-40 mmHg systolic) to cut down your list of medications. Of course, discontinuing medications should be done only under a doctor's supervision.
If you are contemplating one of these diets but would like to accelerate your weight-loss and metabolic-control efforts, the following supplements and strategies can boost your chances of success.
Read more . . .
- Protocol: Obesity and Weight Loss
Many physicians fail to realize that no single fat reduction protocol will work for everyone. That is why overweight people must follow a custom-tailored program to modulate factors in their body that result in excess fat build-up. There are several common culprits that cause aging people to add body fat and to also prevent them from losing it. These missing links are often overlooked, and the result is that most weight loss programs fail.
In this protocol, the mechanisms involved in age-associated weight gain will be discussed, and how an individual can circumvent these metabolic imbalances will be described as well. Most important, overlooked factors that preclude successful weight loss in the majority of people who try to "diet" will be revealed.
Definition: Obesity is defined as an excess accumulation of body fat associated with increased fat cell size and number. The term overweight denotes excessive body weight relative to height.
The most common medical assessment of obesity is "body mass index." Body mass index (BMI) is calculated based on body weight (measured in kilograms) divided by height (measured in meters squared). A person is considered overweight if they have a BMI of 25-29.9. A person with a BMI greater than 30 is classified as being "obese" (Flegal et al. 1998).
The majority of adults in the United States are overweight (BMI over 25), with an increasing number being medically classified as obese (BMI over 30). Unfortunately, the trend is increasing. The prevalence of obesity in the United States has almost doubled compared to the year 1980 (NIH 1998; WHO 1998).
It is clear that excess weight has a dramatic impact on one's health. Obesity is the second leading cause of preventable deaths (tobacco being first). Overweight and obesity are known risk factors for diabetes, heart disease, stroke, hypertension, gallbladder disease, osteoarthritis, sleep apnea, and some forms of cancer (uterine, breast, colorectal, kidney, prostate, pancreatic, and gallbladder).
Why Diets Fail
We know that "dieting" (eating less of something than you usually do) only results in short-term loss of weight. Dieters typically lose lean tissue and not fat.
As early as 1968, the Cecil Textbook of Medicine observed: "Elevation of fasting insulin is the difference between thin and obese individuals" (Beeson et al. 1968). Because insulin blocks the release of fat from storage, most people will not lose stored fat by lowering food intake as long as any insulin is present in the blood.
Too Much Insulin Causes Severe Disease States
A surprising number of studies report that excess serum insulin (hyperinsulinemia) is a major health problem. It appears that excess insulin promotes hypertension by impairing sodium balance. Too much insulin harms the kidneys. The vascular system is also severely damaged by prolonged exposure to excess insulin. By acting as a catalyst in promoting cell growth, excess insulin increases the risk and progression of certain cancers. Excess insulin is even a contributory factor to benign prostate enlargement because of its effects in promoting overgrowth of prostate cells.
For people trying to reduce body fat, excess insulin suppresses the release of growth hormone in addition to preventing fat from being released from cells. High serum insulin is associated with the development of abdominal obesity and the number of health problems this induces, including atherosclerosis and impotence. Obesity is associated with excess insulin and reduced insulin sensitivity, both risk factors for Type II diabetes.
Perhaps the simplest method of evaluating the toxic effects of excess insulin is to look at its effects on human mortality. One early study showed that over a 10-year period, the risk of dying was almost twice as great for those with the highest levels of insulin compared to those with the lowest. The scientists stated that hyperinsulinemia is associated with increased all-cause and cardiovascular mortality, independent of other risk factors (NIH 1985).
Another study showed that the risk of developing coronary artery disease increased by 60% for each single-digit increase in fasting insulin level among men aged 45-76 years (after other risk factors were controlled) (Despres et al. 1996). In optimal health, fasting insulin levels should be in the range of 0-3. As people age, their fasting insulin levels normally increase several single digits. Fasting insulin levels in the obese often exceed 20.
Having too much insulin in the blood has become so commonplace that laboratory reference ranges now indicate that fasting insulin levels of 6-27 mcIU/mL are "normal." While it is normal for aging people to have high fasting insulin, it is by no means desirable. Aging people experience a wide range of degenerative diseases that are directly attributable to elevated insulin.
Standard laboratory reference ranges can sometimes be misleading. For instance, it was once considered normal to have a cholesterol reading of up to 300 (mg/dL). While it is true that a cholesterol count of 300 was normal at that time in history, so was an epidemic of heart attacks. Once the dangers of high cholesterol became known, laboratories reduced the high normal reference range to 200 for cholesterol. We expect that laboratory reference ranges for fasting insulin will eventually be changed to alert physicians to patients with dangerously high serum levels of insulin.
Why Insulin Makes People Hungry
One of the ways that excess insulin results in weight gain is that it causes people to be chronically hungry. A reason for this is that high insulin levels rapidly deplete glucose from the blood. This causes a state known as "reactive hypoglycemia," in which the blood becomes deficient in glucose because too much insulin is in the blood.
Low blood sugar-induced by hyperinsulinemia-produces a ravenous craving for glucose-producing foods. This hyperinsulin state promotes excess food intake and leads to a cycle where even greater amounts of insulin are produced to balance the increased calorie intake. The continuous consumption of glucose-producing foods leads to even more insulin secretion and contributes to the pathological accumulation of body fat.
Published studies show that even modest decreases in blood glucose concentrations are associated with hunger and the initiation of eating (Ludwig 2002). Indeed, insulin-induced hypoglycemia appears to provoke prolonged hunger, persisting long after restoration of normal blood glucose levels.
Furthermore, hyperinsulinemia (Kopf et al. 2001) and reactive hypoglycemia (Wursch et al. 1997) may preferentially stimulate consumption of high-glycemic index foods, leading to cycles of greater insulin secretion, followed by low blood sugar and the inevitable desire to rapidly consume more calories. Weight loss efforts (dieting) may exacerbate this phenomenon, as demonstrated by severe hypoglycemia after overweight subjects who were dieting consumed a high-glycemic index carbohydrate (Ludwig 2002).
This helps to explain why so many diets fail, i.e., chronically high insulin levels cause people to crave the very carbohydrates that are making them fat.
Read the Full Protocol . . .
To see a list of all supplements, please check our Index or use our Search feature.
- Featured Product: 7-Keto DHEA - A natural metabolite of DHEA, has been shown to safely increase thermogenesis and improving fat loss benefits of diet and exercise three-fold. Antioxidants are added based on the effect 7-Keto has in boosting mitochondrial oxidation.
Serving Size: 1 capsule
Servings Per Container: 60
Amount Per Serving
Other ingredients: rice flour, gelatin, magnesium stearate.
- Vitamin C (as ascorbyl palmitate) - 11mg
- Vitamin E (as D-alpha tocopheryl succinate) - 25 IU
- 7-Keto DHEA (3 -Acetyl-7-oxo-dehydroepiandrosterone) - 100mg
- Ascorbyl palmitate - 25mg
- Curcumin C3 Complex® Turmeric (root) extract (Curcuma longa)[Standardized for 95% total curcuminoids (23.75mg)] - 25mg
- Green tea extract, decaffeinated (Camellia sinensis) leaf [Standardized for minimum 90% polyphenols (22.5mg)] - 25mg
- Whole grape extract (Vitis vinifera) and Polygonum cuspidatum(root) extract [Standardized to 35% Resveratrol (1mg)] - 3mg
7-Keto U.S. Patents No. 5,292,730; 5,296,481; 5,585,371; 5,641,766; 5,869,709; 5,885,977.
Curcumin C3 Complex® and Nature's Bioprotectant are registered trademarks of Sabinsa Corp.
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