Indole-3-Carbinol (I3C) - Based on a growing body of evidence that cruciferous vegetable extracts (in addition to I3C) provide bountiful health benefits, Life Extension has reformulated its Indole-3-Carbinol (I3C) supplements to more closely resemble what one would obtain from a vegetable-rich diet. Source: Life Extension Foundation UPC Code: 737870969068 Ingredients: See below. Sale Price: $28.99 + Free Shipping Quantity Price for 4: $99.99 + Free Shipping Take advantage of FREE air shipping in the USA! Read More . . . It is a sad fact that the very hormones we need to stay young can cause adverse effects as we age. Consumption of cruciferous vegetables, however, can favorably alter one's hormone profile. Scientists have identified specific extracts from cruciferous vegetables (broccoli, cauliflower, Brussels sprouts, etc.) that modulate hormones in a way to help maintain healthy cell division. For instance, animal studies have shown that the cruciferous vegetable extract indole-3-carbinol (I3C) modulates estrogen hormones by favorably changing the ratio of protective 2-hydroxyestrone versus the damaging 16-hydroxyestrone.1 Indole-3-carbinol also induces phase I and II detoxifying enzymes that can help neutralize estrogen metabolites and xenobiotic estrogen-like environmental chemicals.2 Human studies support the beneficial role of I3C in positively altering estrogen metabolism.3 Di-indolyl-methane (DIM), a phytonutrient found in cruciferous vegetables, has been shown in animal studies to help maintain normal levels of a potentially damaging estrogen called 4-hydroxyestrone.4 The glucosinolates are major constituents of cruciferous vegetables that have been shown to promote normal apoptosis and induce the expression of the beneficial p53 gene via an estrogen-independent action.5 Watercress contains isothiocyanates, but in a broader spectrum than does broccoli. The primary isothiocyanate precursor (PEiTC) in watercress functions via four specific mechanisms to maintain healthy cell division.6 Extracts from rosemary enhance liver metabolism of estradiol and estrone,7 inhibits the formation of DNA adducts,8 and have been shown to impede estrogen-induced growth promotion in certain tissues.7 For those weighing less than 160 pounds, just one capsule a day of Dual-Action Cruciferous Vegetable Extract provides optimal potencies. Those weighing over 160 pounds should consider taking one capsule twice a day. Supplement Facts Serving Size: 1 capsule Servings Per Container: 60 Amount Per Serving Broccoli (Brassica oleracea l.) Super Concentrate Extract (plants and sprouts) [std. to 4% glucosinolates (16 mg)] - 400 mg Watercress (Nasturtium officinale) 4:1 Extract (leaf) - 100 mg Indole-3-Carbinol (I3C) - 80 mg Rosemary (Rosmarinus officinalis) Extract (leaves) [std. to 20% diterpenic compounds (10 mg), providing carnosic acid/carnosol] - 50 mg Cat's Claw (Uncaria tomentosa) Extract (bark) [std. to 8% carboxy alkyl esters (2 mg)] - 25 mg Resveratrol [from Red Grape (Vitis vinifera) Extract (whole fruit) and Polygonum cuspidatum Extract (root)] - 20 mg DIM (Di-indolyl-methane) - 14 mg Other ingredients: rice flour, vegetable capsule, magnesium stearate, silica. Contains corn and rice. This product contains NO milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), soybeans, tree nuts, wheat, yeast, or gluten. Contains NO sugar, and no artificial sweeteners, flavors, colors, or preservatives. Dosage and Use One capsule daily for individuals weighing up to 160 pounds. Those weighing over 160 pounds, take two capsules daily. This product can be taken with or without food, or as recommended by a healthcare practitioner. Caution: May interfere with oral contraceptives. If pregnant or intending to become pregnant, do not use this product. Do not use if taking antacids, H2-receptor blockers (e.g. Zantac), or proton-pump inhibitors (e.g. Nexium), as these drugs may impede the conversion of I3C to active metabolites. References Biochem Pharm. 2002, 64;393-404. Toxicol Appl Pharm. 2001 Jul 15;174(2):146-52. J Natl Cancer Inst. 1997 May 21;89(10):718-23. Cancer Detect Prevent. 2004;28:72-9. Carcinogenesis. 2002 Apr;23(4):581-6. Mol Cancer Ther. 2003 Oct;2(10);1045-52. Carcinogenesis. 1998 Oct;19(10):1821-7. Carcinogenesis. 1995 Sep;16(9):2057-62. How to Order To order online, click on the "Order" box below. To see a list of all supplements, please check our Index or use our Search feature. If you have any questions, please contact us at info@lifeextensionvitamins.com or 1-888-771-3905. dualactrescatsRetail Price: $32.00Sale Price: $28.99 60: caps Dual Action Cruciferous Extract w/ Cat's Claw & Resveratrol Quantity Price for 4 dualactcatres$99.99 4: bottles FREE AIR MAIL SHIPPING IN THE UNITED STATES! The statements made here have not been evaluated by the FDA. The foregoing statements are based upon sound and reliable studies, and are meant for informational purposes. Consult with your medical practitioner to determine the underlying cause of your symptoms. Copyright 1997-2009 Life Extension Vitamin Supplies and Life Extension Institute, Inc. All rights reserved.